INT76069

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Context Info
Confidence 0.07
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprl1, Oprm1) plasma membrane (Oprl1, Oprm1) signal transducer activity (Oprl1, Oprm1)
Oprl1 (Mus musculus)
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 5 99.88 Very High Very High Very High
Somatostatin 5 92.64 High High
Opioid 2 80.32 Quite High
mu opioid receptor 2 75.00 Quite High
MU agonist 1 73.68 Quite High
addiction 1 61.52 Quite High
tolerance 1 60.64 Quite High
withdrawal 1 59.44 Quite High
narcan 1 25.00 Low Low
Enkephalin 1 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that in the same cell line, after a 1 h pretreatment with agonist, the kappa receptor displays homologous regulation, whereas the mu receptor undergoes only a heterologous form of desensitization. mu receptor desensitization may lead to the alterations of diverse downstream events, whereas kappa receptor regulation apparently occurs at the level of the receptor itself.
kappa receptor Binding (undergoes) of mu receptor associated with agonist
1) Confidence 0.07 Published 1998 Journal Neuroscience Section Abstract Doc Link 9639280 Disease Relevance 0 Pain Relevance 0.73

General Comments

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