INT7608

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1983
Last Reported 2009
Negated 5
Speculated 2
Reported most in Abstract
Documents 66
Total Number 76
Disease Relevance 17.81
Pain Relevance 35.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
neurons 5
spinal 3
locus coeruleus 3
heart 3
endothelium 2
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 335 100.00 Very High Very High Very High
Clonidine 202 100.00 Very High Very High Very High
adenocard 120 100.00 Very High Very High Very High
antagonist 55 100.00 Very High Very High Very High
Opioid 11 100.00 Very High Very High Very High
Analgesic 10 100.00 Very High Very High Very High
antinociception 9 100.00 Very High Very High Very High
Pain 8 100.00 Very High Very High Very High
Potency 6 100.00 Very High Very High Very High
intrathecal 14 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cognitive Disorder 4 100.00 Very High Very High Very High
Sleep Disorders 12 99.98 Very High Very High Very High
Increased Venous Pressure Under Development 42 99.96 Very High Very High Very High
Hypoxia 21 99.90 Very High Very High Very High
Htlv Types I And Ii 351 99.84 Very High Very High Very High
Cv Unclassified Under Development 225 99.80 Very High Very High Very High
Nervous System Injury 3 99.76 Very High Very High Very High
Reperfusion Injury 36 99.44 Very High Very High Very High
Hypertension 12 99.28 Very High Very High Very High
Nociception 3 99.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of alpha2-adrenoceptor down-regulates the activity of protein kinase A that results in the potentiation of the glycinergic inhibitory effects within the spinal dorsal horn.
Positive_regulation (Activation) of alpha2-adrenoceptor in spinal associated with spinal dorsal horn
1) Confidence 0.70 Published 2003 Journal Life Sci. Section Abstract Doc Link 12798415 Disease Relevance 0 Pain Relevance 0.33
These results suggest that the activation of alpha 2 adrenoceptor coupled with IAP-sensitive GTP binding protein decreases the intracellular cyclic AMP and cyclic AMP-dependent protein kinase activity, thus resulting in the potentiation of glycine receptor-mediated taurine response in rat SN neurons.
Positive_regulation (activation) of alpha 2 adrenoceptor in neurons associated with substantia nigra
2) Confidence 0.69 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8899617 Disease Relevance 0.09 Pain Relevance 0.13
As 6-hydroxydopamine pretreatment upregulates alpha 2-adrenergic receptors, these results support the validity of the use of the GH response to clinidine as an index of alpha 2-adrenergic receptor responsiveness.
Positive_regulation (upregulates) of alpha 2-adrenergic
3) Confidence 0.67 Published 1987 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 3104956 Disease Relevance 0 Pain Relevance 0.61
The observed dose-related depression of MAP and HR under basal conditions may be related to specific alpha 2-adrenergic receptor activation of the NTS.
Positive_regulation (activation) of alpha 2-adrenergic associated with depression
4) Confidence 0.64 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2998809 Disease Relevance 0.10 Pain Relevance 0.49
The binding sites for the [3H]clonidine showed the specificity required for the alpha-2 adrenoreceptor.
Positive_regulation (required) of alpha-2 adrenoreceptor associated with clonidine
5) Confidence 0.50 Published 1983 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6134815 Disease Relevance 0 Pain Relevance 0.74
Clonidine-induced hypoactivity and mydriasis are mediated by pre- and postsynaptic alpha 2-adrenoceptors, respectively; therefore the results suggest rats reared in isolation have enhanced presynaptic but unchanged postsynaptic alpha 2-adrenoceptor function.
Positive_regulation (enhanced) of alpha 2-adrenoceptor associated with mydriatic and clonidine
6) Confidence 0.50 Published 1994 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 7862947 Disease Relevance 0.26 Pain Relevance 0.40
The alpha 2-adrenoceptor antagonists idazoxan (1 mumol/l) and rauwolscine (1 mumol/l) failed to increase stimulation-evoked overflow of radioactivity in the absence or presence of the noradrenaline reuptake inhibitor desipramine (1 mumol/l).
Neg (failed) Positive_regulation (increase) of alpha 2-adrenoceptor associated with desipramine, antagonist and noradrenaline
7) Confidence 0.50 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2835686 Disease Relevance 0 Pain Relevance 0.44
To determine the point in the acoustic startle pathway where alpha 2-adrenergic receptor activation might ultimately alter neural transmission, startle responses were elicited electrically from different points along the acoustic startle pathway after systemic administration of clonidine.
Positive_regulation (activation) of alpha 2-adrenergic in neural associated with clonidine
8) Confidence 0.50 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2571168 Disease Relevance 0 Pain Relevance 0.38
alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats.
Positive_regulation (activation) of alpha2-Adrenoceptor in nerve associated with analgesic, spinal cord and clonidine
9) Confidence 0.50 Published 2005 Journal Anesthesiology Section Title Doc Link 15731607 Disease Relevance 0.09 Pain Relevance 0.99
It is concluded that alpha 2-adrenoceptor agonist-induced vasodilation is independent from the existence of the endothelium, and that it is not related to vascular beta- and alpha 2-adrenoceptors and muscarinic receptors, suggesting that the alpha 2-adrenoceptor agonist-induced vasodilation is due to an antagonistic activity towards the vascular alpha 1-adrenoceptors.
Positive_regulation (agonist-induced) of alpha 2-adrenoceptor in endothelium associated with agonist and increased venous pressure under development
10) Confidence 0.50 Published 1990 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1974660 Disease Relevance 0.65 Pain Relevance 0.66
The yohimbine discriminative stimulus was mimicked by the alpha 2-adrenergic receptor antagonist idazoxan and antagonized by the alpha 2-adrenergic receptor agonist clonidine, indicating that the yohimbine stimulus was mediated through the alpha 2-adrenergic receptor.
Positive_regulation (mediated) of alpha 2-adrenergic associated with antagonist, agonist and clonidine
11) Confidence 0.50 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1357678 Disease Relevance 0 Pain Relevance 0.28
These results indicate that: (i) clonidine-evoked activation of alpha2-adrenergic receptors affects the two components of the breathing pattern differently, and this occurs beyond the lung vagi; and (ii) changes in tidal volume result from excitation of the carotid bodies and are coupled with centrally mediated slowing of the respiratory rhythm.
Positive_regulation (activation) of alpha2-adrenergic in lung associated with clonidine
12) Confidence 0.50 Published 2006 Journal Exp. Physiol. Section Abstract Doc Link 16282369 Disease Relevance 0 Pain Relevance 0.56
Clonidine mimicked the NE effect on the Itau, thus indicating the involvement of alpha 2 adrenoceptor activation in the potentiation of Itau. 4.
Positive_regulation (activation) of alpha 2 adrenoceptor associated with clonidine
13) Confidence 0.49 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8899617 Disease Relevance 0 Pain Relevance 0.25
N-[2(methylamino)ethyl]-5-isoquinoline sulfonamide dihydrochloride (H-89) mimicked the effect of alpha 2 adrenoceptor activation on Itau.
Positive_regulation (activation) of alpha 2 adrenoceptor
14) Confidence 0.49 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8899617 Disease Relevance 0.09 Pain Relevance 0.11
Alpha2-adrenoceptor antagonism is neither sufficient nor necessary for the distinctive action of atypical neuroleptics on intracranial self-stimulation in the rat.
Neg (nor) Positive_regulation (necessary) of Alpha2-adrenoceptor
15) Confidence 0.49 Published 2003 Journal Behav Pharmacol Section Title Doc Link 12838036 Disease Relevance 0.08 Pain Relevance 0.25
These results suggest that there is an increase in alpha-2 adrenoceptor activity in aortas from diabetic rats.
Positive_regulation (increase) of alpha-2 adrenoceptor in aortas associated with diabetes mellitus
16) Confidence 0.49 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6094794 Disease Relevance 0.39 Pain Relevance 0.35
Clonidine activation of the alpha 2 adrenergic receptor, which activates Gi, inhibited forskolin--stimulated adenylate cyclase activity in control membranes.
Positive_regulation (activation) of alpha 2 adrenergic receptor associated with clonidine
17) Confidence 0.48 Published 1991 Journal Endocrinology Section Abstract Doc Link 1905225 Disease Relevance 0.32 Pain Relevance 0.10
In the spinal cord, activation of DNIN leads to the release of norepinephrine, which inhibits nociceptive processing through direct activation of alpha2 adrenoceptor and indirect activation of GABAergic neurons through alpha1 adrenoceptor.
Positive_regulation (activation) of alpha2 adrenoceptor in spinal cord associated with nociception and gabaergic
18) Confidence 0.47 Published 2003 Journal Anesthesiology Section Abstract Doc Link 12717145 Disease Relevance 0.10 Pain Relevance 0.50
CONCLUSIONS: Norepinephrine inhibits A delta-fiber- and C-fiber-mediated sensory transmission to substantia gelatinosa neurons through the activation of the alpha 2 adrenoceptor (possibly alpha2A type, based on the current, published behavioral and anatomical data) existing in primary afferent terminals; this action of norepinephrine is more effective in A delta-fiber than C-fiber transmission.
Spec (possibly) Positive_regulation (activation) of alpha 2 adrenoceptor in neurons
19) Confidence 0.47 Published 2003 Journal Anesthesiology Section Body Doc Link 12606912 Disease Relevance 0 Pain Relevance 0
Urapidil did not change the vasodilatory beta 2-adrenoreceptor-mediated effect of isoprenaline.
Neg (not) Positive_regulation (change) of vasodilatory beta 2-adrenoreceptor-mediated
20) Confidence 0.47 Published 1985 Journal J Auton Pharmacol Section Abstract Doc Link 3005330 Disease Relevance 0.16 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox