INT7609

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Context Info
Confidence 0.32
First Reported 1992
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.59
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
myometrium 2
superior 1
endothelium 1
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 93.20 High High
Clonidine 16 92.88 High High
COX-2 inhibitor 1 64.72 Quite High
antagonist 1 59.92 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Toxicity 12 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effectiveness of alpha 2-adrenergic receptor stimulation in reducing the central toxicity following cholinesterase inhibition.
Regulation (Effectiveness) of Positive_regulation (stimulation) of alpha 2-adrenergic associated with toxicity
1) Confidence 0.32 Published 1992 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Title Doc Link 1352646 Disease Relevance 0.59 Pain Relevance 0.32
alpha2-Adrenergic receptor (alpha(2)-AR) activation in the pregnant rat myometrium at midterm potentiates beta(2)-AR stimulation of adenylyl cyclase (AC) via Gbetagamma regulation of the type II isoform of adenylyl cyclase.
Regulation (regulation) of Positive_regulation (activation) of alpha2-Adrenergic receptor in myometrium
2) Confidence 0.05 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11160870 Disease Relevance 0 Pain Relevance 0.20
The present study evaluates the effect of endogenous male sex hormones on the reactivity to alpha2-adrenoceptor activation, and to analyze the role of the endothelium in this response in intact and endothelially denuded superior mesenteric arteries from control and orchidectomized male Sprague-Dawley rats.
Regulation (effect) of in endothelium Positive_regulation (activation) of alpha2-adrenoceptor in superior
3) Confidence 0.03 Published 2006 Journal J. Vasc. Res. Section Abstract Doc Link 16293968 Disease Relevance 0 Pain Relevance 0.14

General Comments

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