INT76094

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Context Info
Confidence 0.72
First Reported 1998
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.76
Pain Relevance 2.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS2) oxidoreductase activity (NOS2) nucleus (NOS2)
intracellular (NOS2) cytoplasm (NOS2)
Anatomy Link Frequency
neuronal 2
macrophages 1
hepatocyte 1
endothelial cell 1
leukocyte 1
NOS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 9 99.36 Very High Very High Very High
Inflammation 181 97.76 Very High Very High Very High
Paracetamol 104 96.04 Very High Very High Very High
Inflammatory response 20 93.08 High High
Snapping jaw 2 92.36 High High
Inflammatory mediators 11 90.96 High High
cytokine 22 90.68 High High
Opioid 4 86.88 High High
Morphine 7 82.80 Quite High
antagonist 5 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 220 97.76 Very High Very High Very High
Disease 39 96.92 Very High Very High Very High
Increased Venous Pressure Under Development 8 94.96 High High
Temporomandibular Joint Syndrome 2 92.36 High High
Injury 20 89.36 High High
Diarrhoea 4 82.80 Quite High
Overdose 2 66.96 Quite High
Acute Liver Failure 2 62.00 Quite High
Metabolic Disorder 2 50.44 Quite High
Colitis 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With respect to the current literature and the clinical findings it is discussed that both increased leukocyte/endothelial cell adhesion and altered release of reactive oxygen species or inducible nitric oxide synthase (iNOS) may play a role in 5-FU-induced colitis.
Localization (release) of iNOS in endothelial cell
1) Confidence 0.72 Published 2007 Journal Strahlenther Onkol Section Body Doc Link 17680227 Disease Relevance 0.08 Pain Relevance 0
Immunohistochemical localization of inducible nitric oxide synthase in synovial tissue of human temporomandibular joints with internal derangement.
Localization (localization) of inducible nitric oxide synthase in temporomandibular joints
2) Confidence 0.70 Published 2001 Journal Arch. Oral Biol. Section Title Doc Link 11163600 Disease Relevance 0.09 Pain Relevance 0.16
In our study we stimulated in vitro J774 macrophages with different concentrations of endomorphin 1 or 2 for measuring nitric oxide release and nitric oxide synthase 2 (NOS 2) mRNA expression.
Localization (release) of NOS 2 in macrophages
3) Confidence 0.70 Published 2007 Journal Neuroscience Section Abstract Doc Link 17197099 Disease Relevance 0.09 Pain Relevance 0.24
-ARs increases production of cAMP, phosphorylated ERK and heightened translation of COX-2 and iNOS in response to agonist activation. ?
Localization (translation) of iNOS associated with agonist
4) Confidence 0.49 Published 2005 Journal Cell Commun Signal Section Body Doc Link PMC1198236 Disease Relevance 0.26 Pain Relevance 0.18
Additionally, constitutive NO release is being associated with positive biomedical phenomena, whereas inducible NO synthase (iNOS)-associated NO release with detrimental consequences in regard to endothelial inflammatory activities.
Neg (NO) Localization (release) of inducible NO synthase associated with inflammation
5) Confidence 0.48 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9641464 Disease Relevance 0.19 Pain Relevance 0.26
With respect to the current literature and the clinical findings it is discussed that both increased leukocyte/endothelial cell adhesion and altered release of reactive oxygen species or inducible nitric oxide synthase (iNOS) may play a role in 5-FU-induced colitis.
Localization (release) of iNOS in leukocyte
6) Confidence 0.24 Published 2007 Journal Strahlenther Onkol Section Body Doc Link 17680227 Disease Relevance 0.08 Pain Relevance 0
Nitric oxide (NO), a gaseous free radical, is released by a family of enzymes, including endothelia NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS), with the formation of stoichiometric amounts of L-citrulline from L-arginine.59 Excessive and prolonged iNOS-mediated NO generation has attracted attention because of its relevance to inflammation.
Localization (released) of iNOS in neuronal associated with inflammation
7) Confidence 0.07 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.84 Pain Relevance 0.46
Nitric oxide (NO), a gaseous free radical, is released by a family of enzymes, including endothelia NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS), with the formation of stoichiometric amounts of L-citrulline from L-arginine.59 Excessive and prolonged iNOS-mediated NO generation has attracted attention because of its relevance to inflammation.
Localization (released) of iNOS in neuronal associated with inflammation
8) Confidence 0.06 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.85 Pain Relevance 0.47
He also found no difference in serum glutathione S-transferase (GST), an indicator of hepatocyte enzyme release similar to ALT and AST [13].
Localization (release) of hepatocyte enzyme in hepatocyte
9) Confidence 0.02 Published 2007 Journal BMC Med Section Body Doc Link PMC1894983 Disease Relevance 0.28 Pain Relevance 0.56

General Comments

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