INT76095

Context Info Confidence 0.55 First Reported 1998 Last Reported 2010 Negated 10 Speculated 8 Reported most in Abstract Documents 117 Total Number 125 Disease Relevance 79.73 Pain Relevance 25.86

isomerase activity (ISYNA1) cytoplasm (ISYNA1)

Anatomy Link Frequency macrophages 9 ECs 7 monocytes 7 neuronal 6 Leucocytes 5 ISYNA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 233 100.00 cytokine 1798 99.98 Acupuncture 34 99.98 qutenza 10 99.80 Inflammation 2104 99.70 cva 80 99.68 Tetrahydrobiopterin 22 99.50 Inflammatory stimuli 9 99.32 Morphine 91 99.12 nMDA receptor 318 98.88

Disease Link Frequency Relevance Heat Injury 940 100.00 Infection 1070 99.98 Burns 27 99.84 Stress 1745 99.82 Drug Induced Neurotoxicity 50 99.82 Osteoporosis 49 99.76 INFLAMMATION 2367 99.70 Apoptosis 385 99.68 Cv General 4 Under Development 39 99.68 Acute Disease 17 99.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and IL-1beta gene expressions were quantified by transcription of mRNA followed by real time and quantitative polymerase chain reaction.

Positive_regulation (inducible) of iNOS

1) Confidence 0.55 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0.08 Pain Relevance 0

It may be possible that iNOS induction and expression dependent on synergistic signals to macrophage/monocyte [45,46], and cytokines and virus products may be acting as different stimuli.

Positive_regulation (induction) of iNOS in monocyte associated with cytokine

2) Confidence 0.51 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.15 Pain Relevance 0.09

Replicating dengue viruses may be necessary for optimal iNOS induction, since rates of iNOS+ cells were much higher than when the inactivated virus was used.

Positive_regulation (induction) of iNOS associated with dengue

3) Confidence 0.51 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.20 Pain Relevance 0.09

Infectious virus, if not crucial, certainly play an important role in inducing iNOS.

Positive_regulation (inducing) of iNOS

4) Confidence 0.51 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.31 Pain Relevance 0

[12-14] is consistent with induction of iNOS during acute disease as reported here for both in vivo and in vitro infection.

Positive_regulation (induction) of iNOS associated with acute disease and infection

5) Confidence 0.51 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.87 Pain Relevance 0

The highest incidence of iNOS activation was from 6 to 10 days of disease (8 out of 20 patients).

Positive_regulation (activation) of iNOS associated with disease

6) Confidence 0.51 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.68 Pain Relevance 0

The inducible isoform of nitric oxide synthase (iNOS) may be expressed early in the inflammatory process.

Positive_regulation (inducible) of iNOS associated with inflammation

7) Confidence 0.50 Published 2003 Journal J. Rheumatol. Section Abstract Doc Link 14677189 Disease Relevance 0.46 Pain Relevance 0.45

These data suggest that cAMP is required for the induction of iNOS in ECs and that NO may directly impair adenylate cyclase activity, preventing iNOS activation.

Positive_regulation (induction) of iNOS in ECs

8) Confidence 0.48 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9641464 Disease Relevance 0 Pain Relevance 0.47

These data suggest that cAMP is required for the induction of iNOS in ECs and that NO may directly impair adenylate cyclase activity, preventing iNOS activation.

Positive_regulation (activation) of iNOS in ECs

9) Confidence 0.48 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9641464 Disease Relevance 0 Pain Relevance 0.43

Exposure of ECs to the NO donor, SNAP, before the addition of LPS + IFN, blocked iNOS induction, whereas preincubation of ECs with inhibitors of NOS, before morphine or anandamide exposure, restored LPS + IFN induction of iNOS, suggesting a direct impact of NO on the regulation of iNOS activity.

Positive_regulation (induction) of iNOS in ECs associated with morphine

10) Confidence 0.48 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9641464 Disease Relevance 0 Pain Relevance 0.63

Nitric oxide (NO), when produced via inducible NO synthase (iNOS) in excess under pathological conditions (e.g., inflammation, endotoxemia, and septic shock), may lead to tissue injury and organ dysfunction.

Positive_regulation (inducible) of iNOS associated with endotoxemia, inflammation, injury and sepsis

11) Confidence 0.47 Published 2008 Journal J Anesth Section Abstract Doc Link 18500613 Disease Relevance 0.39 Pain Relevance 0.19

Interestingly, NAC increased the IL-1beta and iNOS mRNA levels but did not significantly modify COX-2 mRNA expression.

Neg (not) Positive_regulation (increased) of iNOS

12) Confidence 0.40 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0 Pain Relevance 0

Nitric oxide (NO) generated from inducible NO synthase (iNOS) participates in immune and inflammatory responses in many tissues.

Positive_regulation (inducible) of iNOS associated with inflammatory response

13) Confidence 0.40 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921057 Disease Relevance 0.42 Pain Relevance 0.29

This injury results from initial COX inhibition and other local events, with translocation of indigenous luminal bacteria, leading to induction of NO synthase isoform, iNOS, and subsequent production of the cytotoxic moiety, peroxynitrite from NO and superoxide.

Positive_regulation (induction) of iNOS associated with injury

14) Confidence 0.40 Published 2003 Journal Inflammopharmacology Section Abstract Doc Link 15035794 Disease Relevance 0.74 Pain Relevance 0.52

This injury results from initial COX inhibition and other local events, with translocation of indigenous luminal bacteria, leading to induction of NO synthase isoform, iNOS, and subsequent production of the cytotoxic moiety, peroxynitrite from NO and superoxide.

Positive_regulation (leading) of iNOS associated with injury

15) Confidence 0.40 Published 2003 Journal Inflammopharmacology Section Abstract Doc Link 15035794 Disease Relevance 0.74 Pain Relevance 0.52

Increased STAT-1 and iNOS mRNA levels were also observed in DRGs from FIV-infected animals relative to mock-infected controls.

Positive_regulation (Increased) of iNOS

16) Confidence 0.39 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.40 Pain Relevance 0.10

FIV infection up-regulated inducible NO synthase (iNOS), STAT-1, and TNF-alpha mRNA levels in DRG cultures.

Positive_regulation (up-regulated) of iNOS in DRG associated with infection

17) Confidence 0.39 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 1.44 Pain Relevance 0.11

The present studies indicate that FIV infection of DRGs directly contributes to axonal and neuronal injury through a mechanism involving macrophage immune activation, which is mediated by STAT-1 and iNOS activation.

Positive_regulation (activation) of iNOS in neuronal associated with injury and infection

18) Confidence 0.39 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16002713 Disease Relevance 0.74 Pain Relevance 0

The inactivated virus consistently induced low rates of INOS+ monocytes, however differences were statistically insignificant when compared to controls.

Positive_regulation (induced) of INOS in monocytes

19) Confidence 0.37 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.46 Pain Relevance 0

Among 11 patients with normal platelet levels merely 4 had significantly elevated iNOS+ cell ratios.

Positive_regulation (elevated) of iNOS in platelet

20) Confidence 0.37 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.61 Pain Relevance 0

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