INT76096

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2010
Negated 5
Speculated 3
Reported most in Body
Documents 37
Total Number 40
Disease Relevance 14.24
Pain Relevance 6.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
macrophages 4
endothelial cell 4
monocyte 4
alveolar macrophages 2
leucocyte 2
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 751 100.00 Very High Very High Very High
cytokine 636 100.00 Very High Very High Very High
agonist 99 100.00 Very High Very High Very High
Electroencephalography 31 99.52 Very High Very High Very High
dexamethasone 159 99.00 Very High Very High Very High
corticosteroid 226 98.76 Very High Very High Very High
Morphine 213 98.60 Very High Very High Very High
Inflammatory response 86 96.88 Very High Very High Very High
metalloproteinase 26 95.52 Very High Very High Very High
Infliximab 4 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 902 100.00 Very High Very High Very High
Asthma 710 100.00 Very High Very High Very High
Occupational Lung Diseases 259 99.32 Very High Very High Very High
Sepsis 179 99.28 Very High Very High Very High
Infection 113 98.16 Very High Very High Very High
Endotoxemia 25 97.08 Very High Very High Very High
Disease 201 96.40 Very High Very High Very High
Cancer 108 96.24 Very High Very High Very High
Atherosclerosis 48 95.92 Very High Very High Very High
Necrosis 47 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because no increase in the expression of the LPS receptor CD14 could be observed, the increased peritoneal leucocyte count is probably not caused by LPS or LPS-like (possibly peptidoglycan-like) contamination.


Neg (no) Positive_regulation (increase) of Gene_expression (expression) of LPS in leucocyte
1) Confidence 0.49 Published 2003 Journal Nephrol. Dial. Transplant. Section Body Doc Link 12897108 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Results showed more alveolar bone loss in patients with cardiac disease than in patients without cardiac disease, but there was no difference between the groups in the serum levels of endotoxin/LPS or IgG antibody to P. gingivalis.
Positive_regulation (levels) of Gene_expression (antibody) of LPS
2) Confidence 0.49 Published 2008 Journal J. Periodontol. Section Body Doc Link 19053924 Disease Relevance 0.05 Pain Relevance 0
Antagonism of LPS and IFN-gamma induction of iNOS in human saphenous vein endothelium by morphine and anandamide by nitric oxide inhibition of adenylate cyclase.
Positive_regulation (induction) of Gene_expression (Antagonism) of LPS in vein endothelium associated with morphine
3) Confidence 0.22 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 9641464 Disease Relevance 0.18 Pain Relevance 0.31
These authors suggested that rhAPC preserves microvascular patency in severe sepsis [37], which is consistent with the regression of LPS-induced increases in the PVPI and the EVLWI after infusion of rhAPC in the present study.
Positive_regulation (increases) of Gene_expression (regression) of LPS associated with sepsis
4) Confidence 0.20 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.54 Pain Relevance 0.06
Pravastatin did not affect CRP or LPS stimulated MCP-1 cytokine production (Table 2).


Neg (not) Positive_regulation (stimulated) of Gene_expression (production) of LPS associated with cytokine
5) Confidence 0.14 Published 2008 Journal Archives of Drug Information Section Body Doc Link PMC2817441 Disease Relevance 0 Pain Relevance 0.08
Our present study shows that morphine is present in secondary granules and is secreted from neutrophils in response to LPS and IL-8 exposure, suggesting that at least part of the circulating morphine in the blood of septic patients stems from PMN.
Positive_regulation (response) of Gene_expression (exposure) of LPS in stems associated with morphine
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808358 Disease Relevance 0.13 Pain Relevance 1.29
LPS-primed monocytes released inflammatory cytokines, including interleukin-1beta (IL-1?)
Positive_regulation (including) of Gene_expression (primed) of LPS in monocytes associated with inflammation and cytokine
7) Confidence 0.12 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0.29 Pain Relevance 0.29
In fact, we found that LPS caused an increase in intracellular precursors for IL-1?
Positive_regulation (increase) of Gene_expression (caused) of LPS
8) Confidence 0.12 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0.12 Pain Relevance 0.21
The inhibitory effect of Prolastin (0.5 mg/ml) on LPS-stimulated TNF?
Positive_regulation (stimulated) of Gene_expression (effect) of LPS
9) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.07
release was comparable in magnitude to that of native or polymeric AAT, whereas its inhibitory effect on LPS-induced IL-1?
Positive_regulation (induced) of Gene_expression (effect) of LPS
10) Confidence 0.12 Published 2005 Journal Respir Res Section Body Doc Link PMC549028 Disease Relevance 0 Pain Relevance 0.04
Our data on LXA4 is one of the first regarding its stimulated production by LPS, and its suppression by dexamethasone.
Positive_regulation (stimulated) of Gene_expression (production) of LPS associated with dexamethasone
11) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.35 Pain Relevance 0.64
Interestingly, when the data was expressed as a ratio of pro-inflammatory LTB4 to anti-inflammatory LXA4, there was an increased pro-inflammatory imbalance when the macrophages from both asthmatic groups were exposed to LPS, and this was not reversed by corticosteroids.
Positive_regulation (increased) of Gene_expression (exposed) of LPS in macrophages associated with asthma, corticosteroid and inflammation
12) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.11 Pain Relevance 0.42
Basal and LPS-stimulated generation of LTB4
Positive_regulation (generation) of Gene_expression (Basal) of LPS
13) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.87 Pain Relevance 0.06
Our study shows reduced baseline LTB4 in non-severe asthma and no significant differences in stimulated production by LPS compared to non-asthmatics.
Positive_regulation (stimulated) of Gene_expression (production) of LPS associated with asthma and occupational lung diseases
14) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.16 Pain Relevance 0.06
There was a small but significant increase in LPS-induced LXA4 levels in all three groups (Figure 1B), with the lowest amounts in severe compared to non-severe asthma (p < 0.01) and to normal subjects (p < 0.001).
Positive_regulation (induced) of Gene_expression (levels) of LPS associated with asthma
15) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.94 Pain Relevance 0.03
There was a small but significant increase in LPS-induced LXA4 levels in all three groups (Figure 1B), with the lowest amounts in severe compared to non-severe asthma (p < 0.01) and to normal subjects (p < 0.001).
Positive_regulation (increase) of Gene_expression (levels) of LPS associated with asthma
16) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.95 Pain Relevance 0.03
These results are in line with the current observation of reduced basal and LPS-stimulated production of LXA4 from alveolar macrophages of patients with severe asthma.
Positive_regulation (stimulated) of Gene_expression (production) of LPS in alveolar macrophages associated with asthma
17) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.17 Pain Relevance 0
We addressed the question of whether LPS infusion induces changes in EEG, cortisol, BSPs, and CFs.
Spec (whether) Positive_regulation (induces) of Spec (whether) Gene_expression (infusion) of LPS associated with electroencephalography
18) Confidence 0.09 Published 2010 Journal Crit Care Section Body Doc Link PMC2911704 Disease Relevance 1.07 Pain Relevance 0.29
Moreover, although the preliminary experiments confirmed that 10 ng/ml LPS efficiently stimulated PBMCs to produce substantial amounts of TNF protein, anti-TNF-?
Positive_regulation (stimulated) of Gene_expression (produce) of LPS
19) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.30 Pain Relevance 0.05
Cultures were exposed to LPS for 8 h, an exposure duration that produced a robust response to TNF-?
Positive_regulation (Cultures) of Gene_expression (exposed) of LPS
20) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.05 Pain Relevance 0.11

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