INT76098

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 6.05
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) nucleus (IRF6) DNA binding (IRF6)
cytoplasm (IRF6)
Anatomy Link Frequency
monocytes 7
alveolar macrophages 3
macrophages 2
MD2 2
ECs 2
IRF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 84 100.00 Very High Very High Very High
Inflammatory stimuli 11 99.96 Very High Very High Very High
Bile 7 99.76 Very High Very High Very High
rheumatoid arthritis 93 99.72 Very High Very High Very High
Morphine 7 99.50 Very High Very High Very High
Inflammatory mediators 12 99.04 Very High Very High Very High
Potency 1 94.92 High High
Kinase C inhibitor 1 94.24 High High
Inflammation 259 93.16 High High
cytokine 281 92.24 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 328 99.80 Very High Very High Very High
Rheumatoid Arthritis 93 99.72 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 143 96.76 Very High Very High Very High
Disease 96 94.92 High High
Hemorrhage 2 93.00 High High
Apoptosis 21 92.40 High High
Sprains And Strains 13 91.44 High High
Stress 12 90.64 High High
Cv General 2 Under Development 1 90.64 High High
Targeted Disruption 6 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD14-deficient cell lines such as Chinese hamster ovary are unresponsive to LPS at high doses, and cell lines that show poor LPS activation can be converted to show high activation when transfected with the CD14 gene [71].
Positive_regulation (poor) of Positive_regulation (activation) of LPS in ovary
1) Confidence 0.27 Published 2006 Journal Environ Health Section Body Doc Link PMC1489932 Disease Relevance 0.27 Pain Relevance 0.14
In a similar way, wortmannin increases LPS induced TNFalpha gene transcription by a factor of 2 (Figure 4B).
Positive_regulation (increases) of Positive_regulation (induced) of LPS
2) Confidence 0.22 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2819999 Disease Relevance 0.06 Pain Relevance 0.05
Exposure of ECs to the NO donor, SNAP, before the addition of LPS + IFN, blocked iNOS induction, whereas preincubation of ECs with inhibitors of NOS, before morphine or anandamide exposure, restored LPS + IFN induction of iNOS, suggesting a direct impact of NO on the regulation of iNOS activity.
Positive_regulation (restored) of Positive_regulation (induction) of LPS in ECs associated with morphine
3) Confidence 0.21 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9641464 Disease Relevance 0 Pain Relevance 0.63
The infusion of rhAPC, however, decreased the LPS-induced elevations of PAP, Pmo and PVRIdwn with intergroup differences (P < 0.05).
Positive_regulation (induced) of Positive_regulation (elevations) of LPS
4) Confidence 0.20 Published 2008 Journal Crit Care Section Body Doc Link PMC2575593 Disease Relevance 0.34 Pain Relevance 0.04
Monocytes without LPS stimulation exclusively expressed COX-1 on Western blotting analysis, whereas LPS stimulation induced COX-2 expression.
Positive_regulation (induced) of Positive_regulation (stimulation) of LPS in Monocytes
5) Confidence 0.18 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11804398 Disease Relevance 0.16 Pain Relevance 0.49
What are the possible consequences of LPS-stimulated TLR2 expression?
Spec (possible) Positive_regulation (stimulated) of Spec (possible) Positive_regulation (consequences) of LPS
6) Confidence 0.08 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.74 Pain Relevance 0.05
Although higher concentrations of LPS (1000 ng/ml) failed to stimulate significant release of IL-4 and TGF-?
Neg (failed) Positive_regulation (stimulate) of Positive_regulation (concentrations) of LPS
7) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.13 Pain Relevance 0.09
The absence of LPS-stimulated IL-8 release on the amniotic side of the membranes is in contrast to an earlier report showing that LPS increases IL-8 secretion from isolated amnion cells as well as from decidual cells [31]: these differences in response could reflect differences between cell and intact tissue cultures.
Positive_regulation (absence) of Positive_regulation (stimulated) of LPS in amnion
8) Confidence 0.07 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.17 Pain Relevance 0.15
LPS activation of monocytes leads to the induction of the NF-?
Positive_regulation (leads) of Positive_regulation (activation) of LPS in monocytes
9) Confidence 0.07 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.31 Pain Relevance 0
Since monocytes from patients with RA were able to respond to LPS stimulation similarly to monocytes from healthy controls, we proposed that their diminished response in the co-culture assay was due to a disease-specific inhibitory mechanism present in the systemic circulation of patients with RA.
Positive_regulation (respond) of Positive_regulation (stimulation) of LPS in monocytes associated with rheumatoid arthritis and disease
10) Confidence 0.07 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297564 Disease Relevance 0.88 Pain Relevance 0.43
The uptake of LPS by hepatocytes in vivo is through a CD14-TLR4-MD2-dependent mechanism, and is mediated by ?
Positive_regulation (mediated) of Positive_regulation (uptake) of LPS in MD2 associated with agonist
11) Confidence 0.06 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.05 Pain Relevance 0.40
TLR4, in contrast was shown to be upregulated in response to LPS on monocytes and alveolar macrophages in a kinetic similar to that of TLR2 using both flow cytometry and qRT-PCR.
Positive_regulation (upregulated) of Positive_regulation (response) of LPS in alveolar macrophages
12) Confidence 0.06 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.14
release, we investigated whether prolonged LPS stimulation without P2X7 receptor secondary stimulation could also result in IL-1?
Positive_regulation (result) of Positive_regulation (stimulation) of LPS
13) Confidence 0.06 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.10
We found that lipopolysaccharide (LPS) stimulation of mouse Raw 264.7 macrophages resulted in the upregulation of miR-155 and downregulation of miR-125b levels.
Positive_regulation (resulted) of Positive_regulation (stimulation) of LPS in macrophages
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2756627 Disease Relevance 1.10 Pain Relevance 0.09
In the present study, we further found that melittin and bee venom significantly reduced inflammatory stimuli (LPS and SNP)-induced activation of JNK signal, and the JNK signal specific inhibitor SP600215 suppressed the inhibitory effect of melittin and bee venom on the NF-?
Positive_regulation (induced) of Positive_regulation (activation) of LPS associated with inflammatory stimuli
15) Confidence 0.03 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.79 Pain Relevance 0.39
However, iNOS and COX-2 protein expression was markedly increased in response to LPS (1 ?
Positive_regulation (increased) of Positive_regulation (response) of LPS
16) Confidence 0.02 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1874678 Disease Relevance 0.05 Pain Relevance 0.03
TLR4, in contrast was shown to be upregulated in response to LPS on monocytes and alveolar macrophages in a kinetic similar to that of TLR2 using both flow cytometry and qRT-PCR.
Positive_regulation (upregulated) of in monocytes Positive_regulation (response) of LPS in alveolar macrophages
17) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.14

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