INT76099

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 5.71
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4) plasma membrane (ITIH4) cytoplasm (ITIH4)
Anatomy Link Frequency
neuronal 2
spinal 1
endothelium 1
ITIH4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 22 98.82 Very High Very High Very High
cytokine 17 97.24 Very High Very High Very High
chemokine 171 96.96 Very High Very High Very High
Neuropathic pain 76 96.84 Very High Very High Very High
Angina 3 95.76 Very High Very High Very High
dorsal root ganglion 126 91.96 High High
Pain 53 85.68 High High
c fibre 16 85.04 High High
unmyelinated 11 82.72 Quite High
Peripheral nerve injury 15 81.92 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 373 100.00 Very High Very High Very High
Nociception 23 99.96 Very High Very High Very High
Gliosis 12 98.56 Very High Very High Very High
Injury 119 98.32 Very High Very High Very High
Neuropathic Pain 116 96.84 Very High Very High Very High
Myocardial Infarction 3 96.68 Very High Very High Very High
Apoptosis 39 96.44 Very High Very High Very High
Cv General 3 Under Development 3 95.76 Very High Very High Very High
Ganglion Cysts 126 91.96 High High
Pain 40 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect correlates with the increase of radiolabeled ITIH4 in the cellular media of (35)S-labeled HepG2 cells treated with the cytokine.
Positive_regulation (increase) of ITIH4 associated with cytokine
1) Confidence 0.69 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10486281 Disease Relevance 0.17 Pain Relevance 0.14
After the short-term exposure of the vessel endothelium, monocyte adherence is diminished with morphine and anandamide treatment (jointly by -80%), whereas it is enhanced with that of gp120 (approximately 40%), indicating that gp120 enhances the ability of the endothelium to adhere monocytes.
Positive_regulation (enhanced) of gp120 in endothelium associated with morphine
2) Confidence 0.50 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9641470 Disease Relevance 0.24 Pain Relevance 0.51
The serum concentration of the inter-alpha trypsin inhibitor heavy chain 4 protein (ITIH4) increases (from 1.4-3 times) in male patients suffering of different acute-phase processes (myocardial infarction, unstable angina or programmed surgery).
Positive_regulation (increases) of ITIH4 associated with angina and myocardial infarction
3) Confidence 0.50 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10486281 Disease Relevance 0.19 Pain Relevance 0.12
ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells.
Positive_regulation (increases) of ITIH4
4) Confidence 0.50 Published 1999 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 10486281 Disease Relevance 0.18 Pain Relevance 0.12
Singh et al [55] expanded these findings to confirm those of Acquas et al [54] that demonstrated gp120 activation of caspase-3, but extended them to include the actions of Tat which appeared to promote apoptosis via an endonuclease G mechanism.
Positive_regulation (activation) of gp120 associated with apoptosis
5) Confidence 0.48 Published 2006 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC1510947 Disease Relevance 0.97 Pain Relevance 0.04
The changes in MCP1 resemble those observed by Wallace and colleagues (2007) using gp120 alone as well as those observed in other injury models [7,24].
Positive_regulation (using) of gp120 associated with injury
6) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.87 Pain Relevance 0.48
Utilizing a rodent model that incorporates the viral coat protein, gp120, and the NRTI, 2'3'-dideoxycytidine (ddC), we examined the degree to which chemokine receptor signaling via CCR2 and CXCR4 potentially influences the resultant chronic hypernociceptive behavior.
Positive_regulation (incorporates) of gp120 associated with chemokine
7) Confidence 0.22 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2734548 Disease Relevance 0.89 Pain Relevance 0.38
The effect of perineural HIV-1 gp120 on primary sensory neuronal phenotype
Positive_regulation (perineural) of gp120 in neuronal associated with acquired immune deficiency syndrome or hiv infection
8) Confidence 0.21 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.91 Pain Relevance 0.22
Alterations in non-neuronal cells in the DRG following perineural HIV-1 gp120
Positive_regulation (perineural) of gp120 in neuronal associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.21 Published 2007 Journal Pain Section Body Doc Link PMC2706950 Disease Relevance 0.53 Pain Relevance 0.16
Proposed mechanisms underlying gp120 induced chronic nociception include spinal gliosis.
Positive_regulation (induced) of gp120 in spinal associated with nociception and gliosis
10) Confidence 0.19 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.75 Pain Relevance 0.49

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