INT76120

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2011
Negated 8
Speculated 0
Reported most in Body
Documents 102
Total Number 102
Disease Relevance 30.42
Pain Relevance 7.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptprc) plasma membrane (Ptprc)
Anatomy Link Frequency
microglia 11
bone marrow 8
T cells 7
macrophages 6
B cells 5
Ptprc (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 105 99.98 Very High Very High Very High
Inflammation 995 99.92 Very High Very High Very High
cINOD 127 99.84 Very High Very High Very High
Hippocampus 98 99.40 Very High Very High Very High
chemokine 98 98.90 Very High Very High Very High
Spinal cord 149 98.78 Very High Very High Very High
dexamethasone 19 98.78 Very High Very High Very High
aspirin 99 97.32 Very High Very High Very High
Central nervous system 150 97.00 Very High Very High Very High
cytokine 669 94.16 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 91 100.00 Very High Very High Very High
INFLAMMATION 1098 99.92 Very High Very High Very High
Disease 843 99.82 Very High Very High Very High
Conjunctivitis 50 99.72 Very High Very High Very High
Multiple Sclerosis 489 99.44 Very High Very High Very High
Inflammatory Bowel Disease 12 98.96 Very High Very High Very High
Cancer 1371 98.78 Very High Very High Very High
Injury 496 98.28 Very High Very High Very High
Colon Cancer 56 98.20 Very High Very High Very High
Infection 117 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(Figure 2a) Additional flow cytometry data demonstrated that the monocyte cell line has the same markers as monocytes isolated from peripheral blood; specifically, it is CD45 and CD11b positive and F4/80 negative.
Neg (negative) Gene_expression (positive) of CD45 in F4/80
1) Confidence 0.59 Published 2009 Journal J Transl Med Section Body Doc Link PMC2780997 Disease Relevance 0.06 Pain Relevance 0.10
As shown in Fig. 1A (top and bottom panel), the cross-linking of CD45, mainly isoform CD45RB, enhances microglia phagocytosis of A?
Gene_expression (isoform) of CD45RB in microglia
2) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.06 Pain Relevance 0.04
Cross-linking of CD45RB inhibits LPS induced activation of p38 pathway as well as microglial activation
Gene_expression (linking) of CD45RB
3) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0 Pain Relevance 0
Data revealed cross-linking of CD45, particularly the CD45RB isoform, enhances microglial phagocytosis of A?
Gene_expression (isoform) of CD45RB
4) Confidence 0.53 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2366070 Disease Relevance 0.23 Pain Relevance 0.09
As shown in Fig. 1A (top and bottom panel), the cross-linking of CD45, mainly isoform CD45RB, enhances microglia phagocytosis of A?
Gene_expression (mainly) of CD45 in microglia
5) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.06 Pain Relevance 0.04
Data revealed cross-linking of CD45, particularly the CD45RB isoform, enhances microglial phagocytosis of A?
Gene_expression (isoform) of CD45
6) Confidence 0.53 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2366070 Disease Relevance 0.23 Pain Relevance 0.09
In this study, we focused on identifying the signaling mechanisms involved in CD45RB agonism of microglial A?
Gene_expression (agonism) of CD45RB
7) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.83 Pain Relevance 0.33
These data collectively showed that cross-linking CD45RB boosts microglial phagocytosis of A?
Gene_expression (phagocytosis) of CD45RB
8) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.05 Pain Relevance 0
As shown in Fig. 1A (top and bottom panel), the cross-linking of CD45, mainly isoform CD45RB, enhances microglia phagocytosis of A?
Gene_expression (isoform) of CD45 in microglia
9) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.06 Pain Relevance 0.04
To determine the role of the p38 and/or p44/42 MAPK cascades in the CD45RB signaling-mediated microglial phagocytosis of A?
Gene_expression (signaling) of CD45RB
10) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.05 Pain Relevance 0.05
As shown in Fig. 1A (top and bottom panel), the cross-linking of CD45, mainly isoform CD45RB, enhances microglia phagocytosis of A?
Gene_expression (mainly) of CD45RB in microglia
11) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.06 Pain Relevance 0.04
Co-treatment of microglial cells with agonist CD45 antibodies results in significant inhibition of LPS-induced microglial TNF-?
Gene_expression (antibodies) of CD45 in microglial cells associated with agonist
12) Confidence 0.53 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2366070 Disease Relevance 0.21 Pain Relevance 0.10
Some of these cells were treated with PD98059 (5 µM) or SB203580 (5 µM) for 1 h prior to LPS (100 ng/mL), or CD45RB antibody (2.5 µg/mL), isotype control IgG (2.5 µg/mL) or BAM-10 (2.5 µg/mL), in the presence of FITC-A?
Gene_expression (antibody) of CD45RB
13) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0 Pain Relevance 0.05
Activation of microglial cells by upregulated expression of CD45 and induction of Mac-1 therefore parallels the events observed within the CNS parenchyma protected by the BBB during EAE.
Gene_expression (expression) of CD45 in microglial cells associated with multiple sclerosis and central nervous system
14) Confidence 0.49 Published 2005 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1262737 Disease Relevance 0.42 Pain Relevance 0.11
Microglia were separated from macrophages/granulocytes based on CD45 expression, with intermediate levels of CD45 (CD45dim) identifying CD11b+ parenchymal microglia, and high levels of CD45 (CD45high) identifying CD11b+ macrophage/granulocytes [28].
Gene_expression (expression) of CD45 in granulocytes
15) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.21 Pain Relevance 0
Similarly, we found no evidence of altered CD45 expression when comparing stainings with a generally expressed CD45 marker in chimeric and non-chimeric mice 24 hours after pMCAO (Figure 2N, P).
Gene_expression (expression) of CD45
16) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.06 Pain Relevance 0
Because we observed a reduced number of CD11b+CD45dim microglia after pMCAO in BM-chimeric mice versus non-chimeric mice (Figure 2D), we investigated whether irradiation affected cellular CD45 expression resulting in incorrect estimation of cell numbers.
Gene_expression (expression) of CD45 in microglia
17) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0 Pain Relevance 0
However, microglial expression of CD45 was far below that expressed by macrophages/granulocytes, confirming results by others [34].
Gene_expression (expression) of CD45 in granulocytes
18) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.07 Pain Relevance 0.06
Similarly, we found no evidence of altered CD45 expression when comparing stainings with a generally expressed CD45 marker in chimeric and non-chimeric mice 24 hours after pMCAO (Figure 2N, P).
Gene_expression (expressed) of CD45
19) Confidence 0.49 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2585073 Disease Relevance 0.07 Pain Relevance 0
The CD45 antigen family is a group of high molecular weight glycoproteins expressed on the membranes of all leucocytes (haematopoetic cells).
Gene_expression (expressed) of CD45 in leucocytes
20) Confidence 0.46 Published 2008 Journal BMC Surg Section Body Doc Link PMC2248567 Disease Relevance 0.34 Pain Relevance 0.05

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