INT76123

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1998
Last Reported 2011
Negated 13
Speculated 5
Reported most in Abstract
Documents 193
Total Number 199
Disease Relevance 94.17
Pain Relevance 22.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
lipid metabolic process (Lep)
Anatomy Link Frequency
adipocyte 22
plasma 14
body 10
adipose tissue 8
hypothalamus 5
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 651 100.00 Very High Very High Very High
Neuropeptide 200 100.00 Very High Very High Very High
alcohol 68 100.00 Very High Very High Very High
Intracerebroventricular 307 99.98 Very High Very High Very High
Central nervous system 53 99.92 Very High Very High Very High
Morphine 16 99.84 Very High Very High Very High
agonist 497 99.74 Very High Very High Very High
aspirin 35 99.14 Very High Very High Very High
Inflammatory mediators 30 99.08 Very High Very High Very High
medulla 57 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 2402 100.00 Very High Very High Very High
Cancer 578 100.00 Very High Very High Very High
Appetite Loss 394 100.00 Very High Very High Very High
Insulin Resistance 306 100.00 Very High Very High Very High
Necrosis 143 100.00 Very High Very High Very High
Body Weight 1462 99.90 Very High Very High Very High
Hyperinsulinism 51 99.90 Very High Very High Very High
Pancreatitis 138 99.84 Very High Very High Very High
Starvation 208 99.68 Very High Very High Very High
Eating Disorder 221 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, leptin also is synthesized and stored by cells in the gastric mucosa.
Gene_expression (synthesized) of leptin
1) Confidence 0.78 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15591156 Disease Relevance 0.10 Pain Relevance 0
Because LS caused marked increase in leptin production in bovine endothelial cells and because leptin is involved in regulation of body weight we hypothesized that LS might also regulate leptin expression in the brain.
Gene_expression (expression) of leptin in endothelial cells associated with body weight
2) Confidence 0.78 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.60 Pain Relevance 0.11
Because LS caused marked increase in leptin production in bovine endothelial cells and because leptin is involved in regulation of body weight we hypothesized that LS might also regulate leptin expression in the brain.
Gene_expression (production) of leptin in endothelial cells associated with body weight
3) Confidence 0.78 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.69 Pain Relevance 0.12
We employed both immunohistochemistry and in situ hybridization to see whether LS injection leads to leptin overexpression in the brain.
Gene_expression (overexpression) of leptin in brain
4) Confidence 0.78 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.61 Pain Relevance 0.13
They ascribed this to regulation of leptin synthesis by IL1?
Gene_expression (synthesis) of leptin
5) Confidence 0.78 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.52 Pain Relevance 0.12
Leptin expression was studied in multiple brain sections of control and LS-injected rats.
Gene_expression (expression) of Leptin in brain
6) Confidence 0.78 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.56 Pain Relevance 0.13
Some of these processes (e.g., angiogenesis), though not all, might be secondary to increased leptin expression.
Gene_expression (expression) of leptin
7) Confidence 0.78 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.46 Pain Relevance 0.13
Those anti-sense riboprobes were used for in situ hybridization of formalin-fixed, paraffin-embedded tissue samples to detect the production of leptin in rat tissues.
Gene_expression (production) of leptin
8) Confidence 0.78 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.08 Pain Relevance 0
This was accompanied an increase in leptin expression in neurons and peripheral adipose tissues.
Gene_expression (expression) of leptin in neurons
9) Confidence 0.78 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2263016 Disease Relevance 0.29 Pain Relevance 0.11
These findings confirm that leptin has a role in pancreas inflammation, and the inflamed tissue can be the source of local production of leptin.
Gene_expression (production) of leptin in pancreas associated with inflammation
10) Confidence 0.78 Published 2004 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 15572849 Disease Relevance 0.91 Pain Relevance 0.40
Vagal afferent neurons also express receptors for both CCK and leptin, which are believed to interact in controlling food intake.
Gene_expression (express) of leptin in afferent neurons
11) Confidence 0.77 Published 2007 Journal Physiol Res Section Abstract Doc Link 16792473 Disease Relevance 0.15 Pain Relevance 0.09
Leptin is also produced in the stomach and released into the gastrointestinal lumen but the implication of luminal leptin in the regulation of pancreatic enzyme secretion has not been elucidated.
Gene_expression (produced) of Leptin in lumen
12) Confidence 0.77 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15608360 Disease Relevance 0.09 Pain Relevance 0.03
Leptin receptor gene expression in these acini was significantly increased by caerulein and leptin.
Gene_expression (expression) of Leptin
13) Confidence 0.77 Published 2002 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11939719 Disease Relevance 0.69 Pain Relevance 0.31
The aim of this study was to investigate the levels of ghrelin and leptin in pancreatitis of different severities and the relation of these hormones with blood glucose level and proinflammatory cytokines.
Spec (investigate) Gene_expression (levels) of leptin in blood associated with pancreatitis and cytokine
14) Confidence 0.77 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17333355 Disease Relevance 0.45 Pain Relevance 0.10
Hypothalamic GAL and POMC mRNA also displayed daily patterns but with a different time course; GAL and POMC gene expression were elevated 4 h later than NPY mRNA at 1100 h and 1500 h. 2) Although FR to 4 h between 1100 h and 1500 h resulted in maintenance of body weight compared with a steady weight gain in FF rats, the daily patterns of fluctuations in hypothalamic neuropeptide gene expression were abolished. 3) In FF rats, hypothalamic leptin-R and adipocyte leptin gene expression and serum leptin levels displayed a daily pattern temporally different from that of hypothalamic neuropeptide gene expression.
Gene_expression (expression) of leptin-R in body associated with body weight, neuropeptide, weight gain and eating disorder
15) Confidence 0.76 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.54 Pain Relevance 0.16
Groups of FF and FR rats were killed at 4-h intervals during a 24-h period, and hypothalamic NPY, GAL, POMC, and leptin-R gene expression and leptin gene expression were evaluated by RNase protection assays and serum leptin and corticosterone (CORT) levels were estimated by RIA.
Gene_expression (expression) of leptin associated with eating disorder
16) Confidence 0.76 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.36 Pain Relevance 0.19
Adipocyte leptin mRNA remained low during the lights-on phase but increased at the onset of the lights-off phase (1900 h) and remained elevated through the dark phase. 4) Hypothalamic leptin-R gene expression, like that of adipocyte leptin gene expression, rose abruptly at the onset of nocturnal feeding behavior but receded progressively to low range thereafter. 5) On the other hand, a dichotomy in the daily rise in adipocyte leptin gene expression and leptin secretion was observed in FF rats.
Gene_expression (expression) of leptin in adipocyte
17) Confidence 0.76 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.44 Pain Relevance 0.12
Groups of FF and FR rats were killed at 4-h intervals during a 24-h period, and hypothalamic NPY, GAL, POMC, and leptin-R gene expression and leptin gene expression were evaluated by RNase protection assays and serum leptin and corticosterone (CORT) levels were estimated by RIA.
Gene_expression (expression) of leptin-R associated with eating disorder
18) Confidence 0.76 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.36 Pain Relevance 0.19
Adipocyte leptin mRNA remained low during the lights-on phase but increased at the onset of the lights-off phase (1900 h) and remained elevated through the dark phase. 4) Hypothalamic leptin-R gene expression, like that of adipocyte leptin gene expression, rose abruptly at the onset of nocturnal feeding behavior but receded progressively to low range thereafter. 5) On the other hand, a dichotomy in the daily rise in adipocyte leptin gene expression and leptin secretion was observed in FF rats.
Gene_expression (expression) of leptin-R in adipocyte
19) Confidence 0.76 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.43 Pain Relevance 0.13
To further understand the interplay between the central appetite-stimulating- and peripheral appetite-inhibiting signals in the management of daily food intake, we have examined the daily patterns in expression of the hypothalamic neuropeptides and leptin receptor (R) and adipocyte leptin gene expression and secretion in freely feeding (FF) rats.
Gene_expression (expression) of leptin in adipocyte associated with neuropeptide
20) Confidence 0.76 Published 1999 Journal Endocrinology Section Abstract Doc Link 10342879 Disease Relevance 0.34 Pain Relevance 0.22

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox