INT76138

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Context Info
Confidence 0.72
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 5.79
Pain Relevance 11.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
nerve 2
skin 2
DRG 2
stem cells 2
molecular layer 1
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 110 100.00 Very High Very High Very High
opioid receptor 38 100.00 Very High Very High Very High
Opioid 17 100.00 Very High Very High Very High
Morphine 23 99.82 Very High Very High Very High
Neuropathic pain 11 99.64 Very High Very High Very High
medulla 2 98.64 Very High Very High Very High
Dynorphin 9 97.44 Very High Very High Very High
allodynia 24 95.56 Very High Very High Very High
Pain 37 94.00 High High
Dopamine 5 90.32 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 38 99.64 Very High Very High Very High
Reprotox - General 1 94 99.20 Very High Very High Very High
Nervous System Injury 18 99.02 Very High Very High Very High
Metastasis 5 96.32 Very High Very High Very High
Sprains And Strains 10 95.92 Very High Very High Very High
Pain 39 94.00 High High
Nociception 15 92.72 High High
Targeted Disruption 15 90.80 High High
Embryonal Carcinoma 4 89.76 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 76.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of total KOR and variants B and C mRNA increased ipsilaterally in dorsal root ganglia (DRG) of PB+ mice, whereas KOR variant A mRNA was not detected in DRG.
Neg (not) Transcription (detected) of KOR in DRG associated with kappa opioid receptor
1) Confidence 0.72 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984632 Disease Relevance 0.55 Pain Relevance 0.77
This study examined the contribution of nerve injury alone or nerve injury with signs of neuropathic pain to alteration of kappa opioid receptor (KOR) mRNA expression.
Transcription (expression) of kappa opioid receptor in nerve associated with nervous system injury, kappa opioid receptor and neuropathic pain
2) Confidence 0.72 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984632 Disease Relevance 0.60 Pain Relevance 0.59
This study examined the contribution of nerve injury alone or nerve injury with signs of neuropathic pain to alteration of kappa opioid receptor (KOR) mRNA expression.
Transcription (expression) of KOR in nerve associated with nervous system injury, kappa opioid receptor and neuropathic pain
3) Confidence 0.72 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984632 Disease Relevance 0.60 Pain Relevance 0.59
Nitric oxide (NO) suppressed the transcription of the mouse kappa opioid receptor (KOR) gene, mediated by a rapid downregulation of c-myc gene expression.
Transcription (transcription) of KOR associated with kappa opioid receptor
4) Confidence 0.70 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.09 Pain Relevance 0.21
It is proposed that NO regulates KOR at the level of gene transcription, mediated by a rapid suppression of c-myc gene expression and its binding to KOR promoters, and followed by chromatin hypoacetylation of and reduced transcription from KOR promoters in P19 stem cells.
Transcription (transcription) of KOR in stem cells associated with kappa opioid receptor
5) Confidence 0.59 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.06 Pain Relevance 0.44
A segment of KOR transcript spanning the second extracellular loop, which has the reported dynorphin specificity, and the seventh transmembrane domain of the receptor was amplified from the total RNA of morphine-treated CEM x174 lymphocytes, along with a competitor molecule.
Transcription (transcript) of KOR in lymphocytes associated with dynorphin, kappa opioid receptor and morphine
6) Confidence 0.51 Published 2001 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 11727785 Disease Relevance 0.16 Pain Relevance 1.56
Expression of total KOR and variants B and C mRNA increased ipsilaterally in dorsal root ganglia (DRG) of PB+ mice, whereas KOR variant A mRNA was not detected in DRG.
Transcription (Expression) of KOR in DRG associated with kappa opioid receptor
7) Confidence 0.47 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10984632 Disease Relevance 0.58 Pain Relevance 0.76
It is proposed that NO regulates KOR at the level of gene transcription, mediated by a rapid suppression of c-myc gene expression and its binding to KOR promoters, and followed by chromatin hypoacetylation of and reduced transcription from KOR promoters in P19 stem cells.
Transcription (transcription) of KOR in stem cells associated with kappa opioid receptor
8) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.06 Pain Relevance 0.44
The suppressive effect of NO on KOR occurred at the level of gene transcription, mediated by E boxes located in promoters I and II of this gene.
Transcription (transcription) of KOR associated with kappa opioid receptor
9) Confidence 0.45 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.08 Pain Relevance 0.30
Two of the QTL reported, Morph1 and Morph4 co-localise with the strong candidate genes, Oprk and Oprm, which encode kappa (?
Transcription (Two) of Oprk
10) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 1.21 Pain Relevance 0.79
Approximately 34% of the cells present in the molecular layer express KOR mRNA.
Transcription (express) of KOR in molecular layer associated with kappa opioid receptor
11) Confidence 0.25 Published 2005 Journal Cell Tissue Res. Section Abstract Doc Link 15778854 Disease Relevance 0.23 Pain Relevance 0.53
Expression profiles of genes in CRPC support a role for the transcriptional activity of the androgen receptor (CCNH, CUEDC2, FLNA, PSMA7), steroid synthesis and metabolism (DHCR24, DHRS7, ELOVL5, HSD17B4, OPRK1), neuroendocrine (ENO2, MAOA, OPRK1, S100A10, TRPM8), and proliferation (GAS5, GNB2L1, MT-ND3, NKX3-1, PCGEM1, PTGFR, STEAP1, TMEM30A), but neither supported nor discounted a role for cell survival genes.


Transcription (activity) of OPRK1 in ND3 associated with reprotox - general 1
12) Confidence 0.22 Published 2010 Journal BMC Med Genomics Section Abstract Doc Link PMC2956710 Disease Relevance 0.83 Pain Relevance 0
Delta-opioid receptor mRNA appears only at G17 and kappa-opioid receptor mRNA is not observed before adulthood.
Transcription (appears) of kappa-opioid receptor mRNA associated with kappa opioid receptor and opioid receptor
13) Confidence 0.17 Published 2002 Journal Neuroscience Section Abstract Doc Link 12044478 Disease Relevance 0.42 Pain Relevance 0.75
Skin fibroblasts in culture expressed DOR and KOR mRNA.
Transcription (expressed) of KOR in Skin
14) Confidence 0.10 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16263089 Disease Relevance 0.08 Pain Relevance 0.75
All skin tissue samples expressed delta- (DOR) and kappa-OR (KOR) mRNAs.
Transcription (expressed) of KOR in skin associated with opioid receptor
15) Confidence 0.09 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16263089 Disease Relevance 0.08 Pain Relevance 0.79
We determined the effects of morphine on mRNA levels for the opioid ligands preprodynorphin (PPD) and preproenkephalin (PPE) and the kappa opioid receptor (KOR).
Transcription (levels) of KOR associated with kappa opioid receptor, opioid and morphine
16) Confidence 0.08 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10095091 Disease Relevance 0 Pain Relevance 0.70
There were increases in PPD and KOR mRNA levels (P<0.05 and P<0.005, respectively), with no alteration of PPE.
Transcription (levels) of KOR associated with kappa opioid receptor
17) Confidence 0.06 Published 1999 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 10095091 Disease Relevance 0 Pain Relevance 0.70
By using RT-PCR and Southern hybridization, we confirmed these observations and, in addition, we observed that KOR mRNA was expressed in oligodendrocytes and in the precursors of astrocytes and oligodendrocytes.
Transcription (expressed) of KOR in oligodendrocytes associated with kappa opioid receptor
18) Confidence 0.03 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9645969 Disease Relevance 0.06 Pain Relevance 0.27
KOR mRNA level was the highest in the immature astrocytes and decreased with their maturation.
Transcription (level) of KOR in astrocytes associated with kappa opioid receptor
19) Confidence 0.03 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9645969 Disease Relevance 0.07 Pain Relevance 0.30
These data suggest that the initial effect of EGF is to first enhance KOR translation, which is independent of the effect of EGF on KOR mRNA export that occurs later (Fig. 5, A and B).
Transcription (export) of KOR
20) Confidence 0.02 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0 Pain Relevance 0

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