INT76139

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.22
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
astrocytes 2
stem cells 2
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 26 100.00 Very High Very High Very High
Opioid 3 92.40 High High
opioid receptor 1 27.04 Quite Low
Disease Link Frequency Relevance Heat
Embryonal Carcinoma 2 89.76 High High
Leukemia 1 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nitric oxide (NO) suppressed the transcription of the mouse kappa opioid receptor (KOR) gene, mediated by a rapid downregulation of c-myc gene expression.
Negative_regulation (suppressed) of Transcription (transcription) of KOR associated with kappa opioid receptor
1) Confidence 0.57 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.09 Pain Relevance 0.21
It is proposed that NO regulates KOR at the level of gene transcription, mediated by a rapid suppression of c-myc gene expression and its binding to KOR promoters, and followed by chromatin hypoacetylation of and reduced transcription from KOR promoters in P19 stem cells.
Negative_regulation (reduced) of Transcription (transcription) of KOR in stem cells associated with kappa opioid receptor
2) Confidence 0.36 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.06 Pain Relevance 0.44
KOR mRNA level was the highest in the immature astrocytes and decreased with their maturation.
Negative_regulation (decreased) of Transcription (level) of KOR in astrocytes associated with kappa opioid receptor
3) Confidence 0.02 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9645969 Disease Relevance 0.08 Pain Relevance 0.30

General Comments

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