INT7614

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Context Info
Confidence 0.04
First Reported 1992
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.87
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Vom2r2) signal transducer activity (Vom2r2)
Anatomy Link Frequency
mesangial cells 1
Vom2r2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 99.96 Very High Very High Very High
analgesia 2 99.72 Very High Very High Very High
nMDA receptor 1 99.40 Very High Very High Very High
intrathecal 5 98.10 Very High Very High Very High
Inflammation 2 85.96 High High
cINOD 1 81.44 Quite High
Analgesic 2 75.00 Quite High
Glutamate 1 75.00 Quite High
tail-flick 1 73.60 Quite High
Disease Link Frequency Relevance Heat
Renal Disease 3 96.84 Very High Very High Very High
Nephritis 1 96.16 Very High Very High Very High
INFLAMMATION 3 85.96 High High
Nociception 3 85.36 High High
Injury 1 75.00 Quite High
Shock 1 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that IT glycine acting through the strychnine-sensitive Gly1 receptor produces analgesia provided its effect on the Gly2 receptor linked to the NMDA receptor is prevented by an antagonist.
Regulation (effect) of Gly2 receptor associated with antagonist, nmda receptor, analgesia and intrathecal
1) Confidence 0.04 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1352898 Disease Relevance 0.31 Pain Relevance 0.67
In this study we assessed the effect of a TxA2 synthase inhibitor, Dazmegrel, and a TxA2 receptor antagonist, SQ-29 548, on glomerular PGE2, LTB4, and 12-HETE synthesis in a model of mesangial nephritis induced in the rat by the administration of a monoclonal antibody against the Thy 1.1 antigen of rat mesangial cells.
Regulation (effect) of TxA2 receptor in mesangial cells associated with nephritis and antagonist
2) Confidence 0.03 Published 1999 Journal J. Lab. Clin. Med. Section Abstract Doc Link 10560941 Disease Relevance 0.56 Pain Relevance 0.22

General Comments

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