INT76142

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
astrocytes 2
oligodendrocytes 2
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Substantia nigra 2 99.68 Very High Very High Very High
Central nervous system 10 99.46 Very High Very High Very High
agonist 1 97.40 Very High Very High Very High
dexamethasone 1 96.54 Very High Very High Very High
Kappa opioid receptor 8 91.72 High High
opioid receptor 1 85.04 High High
Opioid 1 73.44 Quite High
Acupuncture 1 11.36 Low Low
bDMF 1 7.56 Low Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 1 84.32 Quite High
Parkinsonian Disorders 1 76.96 Quite High
Pressure And Volume Under Development 1 63.52 Quite High
Disease 3 60.32 Quite High
Paralysis 11 51.52 Quite High
Injury 9 39.60 Quite Low
Neuropathic Pain 1 38.12 Quite Low
Death 3 28.20 Quite Low
Facial Nerve Injuries 6 5.00 Very Low Very Low Very Low
Amputation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In oligodendrocytes, it also decreased with cAMP, but increased under the effect of bFGF and PDGF-BB.
Positive_regulation (increased) of Regulation (effect) of bFGF in oligodendrocytes
1) Confidence 0.47 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9645969 Disease Relevance 0.08 Pain Relevance 0.40
Moreover, dexamethasone, a potent synthetic glucocorticoid agonist, was shown to induce the FGF-2 gene expression in primary culture of rat astrocytes from different CNS regions [86], and also to increase FGF-2 immunoreactivity in the substantia nigra astrocytes [88], further emphasizing the influence of steroid hormones on astroglial FGF-2 mechanisms.
Positive_regulation (increase) of Regulation (immunoreactivity) of FGF-2 in astrocytes associated with substantia nigra, agonist, central nervous system and dexamethasone
2) Confidence 0.47 Published 2010 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2995486 Disease Relevance 0.25 Pain Relevance 0.24

General Comments

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