INT76162

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 0.64
Pain Relevance 8.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
thalamus 4
nucleus 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 80 100.00 Very High Very High Very High
agonist 39 100.00 Very High Very High Very High
mu opioid receptor 9 100.00 Very High Very High Very High
Morphine 23 99.88 Very High Very High Very High
narcan 9 99.84 Very High Very High Very High
Opioid 9 99.08 Very High Very High Very High
Thalamus 12 99.04 Very High Very High Very High
Enkephalin 16 97.04 Very High Very High Very High
MU agonist 2 90.24 High High
antagonist 5 89.56 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 96.28 Very High Very High Very High
Pain 4 75.00 Quite High
Drug Dependence 1 69.48 Quite High
Nociception 2 52.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that in the thalamus of rats chronically treated with morphine, the enhancement of mu receptor phosphorylation in basal and DAMGO-treated samples paralleled the desensitization of DAMGO-mediated inhibition of adenylyl cyclase.
Positive_regulation (enhancement) of Phosphorylation (phosphorylation) of mu receptor in thalamus associated with thalamus and morphine
1) Confidence 0.69 Published 2001 Journal Brain Res. Section Abstract Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.76
Agonist-induced mu opioid receptor phosphorylation and functional desensitization in rat thalamus.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of mu opioid receptor in thalamus associated with mu opioid receptor, agonist and thalamus
2) Confidence 0.69 Published 2001 Journal Brain Res. Section Title Doc Link 11306006 Disease Relevance 0 Pain Relevance 0.44
We have recently identified the serine residues, Ser(261) and Ser(266), within the third intracellular loop as two consensus calcium/calmodulin-dependent protein kinase II (CaMKII) sites required for agonist-induced phosphorylation and desensitization of the mu-opioid receptor in HEK 293 cells.
Positive_regulation (required) of Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist and opioid receptor
3) Confidence 0.67 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11146127 Disease Relevance 0.20 Pain Relevance 1.07
Mutation of Ser(355) and Thr(357) also greatly impaired DAMGO-induced mu-opioid receptor phosphorylation.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of mu-opioid receptor associated with opioid receptor
4) Confidence 0.51 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 12123746 Disease Relevance 0 Pain Relevance 0.70
We have recently identified the serine residues, Ser(261) and Ser(266), within the third intracellular loop as two consensus calcium/calmodulin-dependent protein kinase II (CaMKII) sites required for agonist-induced phosphorylation and desensitization of the mu-opioid receptor in HEK 293 cells.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist and opioid receptor
5) Confidence 0.45 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11146127 Disease Relevance 0.20 Pain Relevance 1.06
There is no evidence that agonist-induced mu-opioid receptor phosphorylation changes in chronically morphine-treated animals, although receptor regulation appears to be altered.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist, opioid receptor and morphine
6) Confidence 0.32 Published 2005 Journal Neurosignals Section Abstract Doc Link 16772732 Disease Relevance 0.07 Pain Relevance 1.07
Although morphine and related alkaloids as well as some peptide agonists (PLO17 and beta-endorphin) stimulated phosphorylation of MOR-1 by PKA, the potent mu-opioid-selective peptide [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin (DAMGO) or other enkephalin analogues such as [D-Ala2]-Met5-enkephalinamide (DALA), [D-Ala2,D-Leu5]-enkephalin (DADLE), and Met5-enkephalin had no effect.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of MOR-1 associated with agonist, enkephalin, opioid and morphine
7) Confidence 0.17 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9648870 Disease Relevance 0.08 Pain Relevance 1.22
The present study demonstrates a conditional, agonist-dependent phosphorylation of the mu-opioid receptor (MOR-1) by cyclic AMP-dependent protein kinase (PKA) in membrane preparations of MOR-1-transfected neuroblastoma Neuro2A cells.
Positive_regulation (dependent) of Phosphorylation (phosphorylation) of MOR-1 associated with neuroblastoma, agonist and opioid receptor
8) Confidence 0.16 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9648870 Disease Relevance 0.10 Pain Relevance 0.66
Involvement of mitogen-activated protein kinase in agonist-induced phosphorylation of the mu-opioid receptor in HEK 293 cells.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist and opioid receptor
9) Confidence 0.13 Published 2000 Journal J. Neurochem. Section Title Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.58
Involvement of mitogen-activated protein kinase in agonist-induced phosphorylation of the mu-opioid receptor in HEK 293 cells.
Positive_regulation (Involvement) of Phosphorylation (phosphorylation) of mu-opioid receptor associated with agonist and opioid receptor
10) Confidence 0.09 Published 2000 Journal J. Neurochem. Section Title Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.58
Activation of the MAPK cascade in turn may not only relay mitogenic signals to the nucleus but also trigger initial events leading to phosphorylation and desensitization of the mu-opioid receptor.
Positive_regulation (leading) of Phosphorylation (phosphorylation) of mu-opioid receptor in nucleus associated with opioid receptor
11) Confidence 0.08 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10617147 Disease Relevance 0 Pain Relevance 0.59

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