INT76165

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Context Info
Confidence 0.00
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.08
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
IGKV2-30 (Homo sapiens)
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 4 99.96 Very High Very High Very High
Opioid 1 99.08 Very High Very High Very High
Morphine 3 98.86 Very High Very High Very High
Enkephalin 6 97.04 Very High Very High Very High
narcan 1 90.96 High High
antagonist 1 90.60 High High
MU agonist 1 84.44 Quite High
opioid receptor 2 78.72 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 83.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although morphine and related alkaloids as well as some peptide agonists (PLO17 and beta-endorphin) stimulated phosphorylation of MOR-1 by PKA, the potent mu-opioid-selective peptide [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin (DAMGO) or other enkephalin analogues such as [D-Ala2]-Met5-enkephalinamide (DALA), [D-Ala2,D-Leu5]-enkephalin (DADLE), and Met5-enkephalin had no effect.
PLO17 Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of MOR-1 associated with agonist, enkephalin, opioid and morphine
1) Confidence 0.00 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9648870 Disease Relevance 0.08 Pain Relevance 1.22

General Comments

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