INT7619

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Context Info
Confidence 0.24
First Reported 1992
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.09
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (TPO) oxidoreductase activity (TPO) plasma membrane (TPO)
cellular nitrogen compound metabolic process (TPO) cytoplasm (TPO)
Anatomy Link Frequency
plasma 1
muscle 1
nerves 1
TPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 9 99.56 Very High Very High Very High
Pain 10 73.04 Quite High
nociceptor 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Multiple System Atrophy 25 100.00 Very High Very High Very High
Autonomic Nervous System Disease 8 99.80 Very High Very High Very High
Disease 6 99.74 Very High Very High Very High
Ataxia 2 98.96 Very High Very High Very High
Injury 2 98.44 Very High Very High Very High
Pressure Volume 2 Under Development 1 92.76 High High
Myalgia 4 73.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HS-related changes in MSA activity were completely abolished after the nerves to corresponding muscles were cut, confirming the reflex nature of the effects.
Regulation (changes) of MSA in nerves associated with multiple system atrophy
1) Confidence 0.24 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 11819039 Disease Relevance 0.38 Pain Relevance 0.06
The mean rate of discharge and the depth of modulation of the MSA responses to sinusoidal stretching of the receptor-bearing muscle were calculated.
Regulation (modulation) of MSA in muscle associated with multiple system atrophy
2) Confidence 0.24 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 11819039 Disease Relevance 0.17 Pain Relevance 0.07
After clonidine, plasma GH concentrations increased in controls and PAF, with no change in MSA.
Neg (no) Regulation (change) of MSA in plasma associated with autonomic nervous system disease, multiple system atrophy and clonidine
3) Confidence 0.05 Published 1992 Journal Lancet Section Abstract Doc Link 1353191 Disease Relevance 1.33 Pain Relevance 0.35
We studied GH release in response to clonidine in 7 IPD patients, 6 MSA patients, 4 patients affected by idiopathic late-onset cerebellar ataxia (ILOCA) and 8 healthy controls.
Regulation (affected) of MSA associated with ataxia, multiple system atrophy, disease and clonidine
4) Confidence 0.01 Published 2001 Journal Neurol. Sci. Section Abstract Doc Link 11487211 Disease Relevance 1.22 Pain Relevance 0.41

General Comments

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