INT76197

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.06
Pain Relevance 7.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADORA1) endoplasmic reticulum (ADORA1) plasma membrane (ADORA1)
cell-cell signaling (ADORA1) signal transducer activity (ADORA1)
Anatomy Link Frequency
peripheral nerve 1
ADORA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 217 100.00 Very High Very High Very High
Pain 24 100.00 Very High Very High Very High
nociceptor 4 100.00 Very High Very High Very High
Analgesic 3 100.00 Very High Very High Very High
Kinase C 20 99.98 Very High Very High Very High
antinociception 4 99.56 Very High Very High Very High
Inflammation 173 99.36 Very High Very High Very High
central sensitization 1 97.24 Very High Very High Very High
methotrexate 100 96.96 Very High Very High Very High
rheumatoid arthritis 8 96.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 4 99.80 Very High Very High Very High
INFLAMMATION 174 99.36 Very High Very High Very High
Pain 25 98.88 Very High Very High Very High
Rheumatoid Arthritis 14 96.12 Very High Very High Very High
Disease 8 94.52 High High
Hyperalgesia 1 91.12 High High
Neuropathic Pain 5 90.60 High High
Targeted Disruption 92 86.56 High High
Arthritis 6 70.24 Quite High
Bordatella Infection 2 30.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, co-activation of the adenosine A1 receptor (but not the 5-HT1B receptor) potentiates the hydrolysis of inositol phospholipids elicited by receptors coupled to Gq-proteins (Dickenson and Hill, 1996.
Positive_regulation (activation) of adenosine A1 receptor associated with adenocard
1) Confidence 0.59 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652344 Disease Relevance 0 Pain Relevance 0.09
Such pain-relieving effects, which are mostly mediated via central adenosine A1 receptor activation, have a slow onset and long duration of action, lasting usually for hours or days and occasionally for months.
Positive_regulation (activation) of adenosine A1 receptor associated with pain and adenocard
2) Confidence 0.48 Published 2005 Journal J Anesth Section Abstract Doc Link 16032451 Disease Relevance 1.29 Pain Relevance 1.82
At peripheral nerve terminals in rodents, adenosine A1 receptor activation produces antinociception by decreasing, while adenosine A1 receptor activation produces pronociceptive or pain enhancing properties by increasing, cyclic AMP levels in the sensory nerve terminal.
Positive_regulation (activation) of adenosine A1 receptor in peripheral nerve associated with pain, antinociception and adenocard
3) Confidence 0.47 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9650842 Disease Relevance 0.59 Pain Relevance 0.92
Adenosine receptor activation and nociception.
Positive_regulation (activation) of Adenosine receptor associated with nociception and adenocard
4) Confidence 0.47 Published 1998 Journal Eur. J. Pharmacol. Section Title Doc Link 9650842 Disease Relevance 0.71 Pain Relevance 1.62
In ischemic preconditioning, it has been shown that PKC is most likely downstream of the adenosine receptor, because the combination of PKC activation and adenosine receptor blockade was protective, whereas adenosine receptor activation in combination with PKC blockade was not [13].
Positive_regulation (activation) of adenosine receptor associated with adenocard and kinase c
5) Confidence 0.01 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2862957 Disease Relevance 0 Pain Relevance 0.38
In ischemic preconditioning, it has been shown that PKC is most likely downstream of the adenosine receptor, because the combination of PKC activation and adenosine receptor blockade was protective, whereas adenosine receptor activation in combination with PKC blockade was not [13].
Positive_regulation (activation) of adenosine receptor associated with adenocard and kinase c
6) Confidence 0.01 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2862957 Disease Relevance 0 Pain Relevance 0.38
Since adenosine receptor activation modulates the release of IL-10 by different inflammatory cells [25-27] and methotrexate-treated rheumatoid arthritis patients have shown increased serum levels of this cytokine [28,29], we determined whether constitutively or methotrexate-modified IL-10 accumulation in the inflammatory exudate was altered in adenosine receptor-deficient mice.
Positive_regulation (activation) of adenosine receptor associated with adenocard, inflammation, rheumatoid arthritis, methotrexate and cytokine
7) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.21 Pain Relevance 0.74
We therefore conclude it is probable that the requirement for activation of multiple adenosine receptor subtypes in the pharmacologic control of chronic inflammation results from the involvement of different types of inflammatory cells and disease-specific differences in the inflammatory environment.


Positive_regulation (activation) of adenosine receptor associated with adenocard, inflammation and disease
8) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.26 Pain Relevance 1.04

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