INT76198

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.53
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADORA3) plasma membrane (ADORA3) signal transducer activity (ADORA3)
Anatomy Link Frequency
sensory nerve 1
lung 1
ADORA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 32 100.00 Very High Very High Very High
Pain 8 99.60 Very High Very High Very High
agonist 92 93.96 High High
antinociception 2 93.12 High High
Inflammation 9 83.68 Quite High
Potency 14 77.68 Quite High
antagonist 19 75.96 Quite High
Spinal cord 1 71.44 Quite High
Antinociceptive 2 67.12 Quite High
Neuropathic pain 2 61.84 Quite High
Disease Link Frequency Relevance Heat
Pain 7 99.60 Very High Very High Very High
Lung Injury 9 98.52 Very High Very High Very High
Apoptosis 14 97.44 Very High Very High Very High
Adult Respiratory Distress Syndrome 13 85.84 High High
INFLAMMATION 12 83.68 Quite High
Nociception 2 75.00 Quite High
Hyperoxia 1 68.72 Quite High
Neuropathic Pain 2 61.84 Quite High
Injury 4 53.68 Quite High
Sepsis 46 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenosine A3 receptor activation produces pain behaviours due to the release of histamine and 5-hydroxytryptamine from mast cells and subsequent actions on the sensory nerve terminal.
Positive_regulation (activation) of Adenosine A3 receptor in sensory nerve associated with pain and adenocard
1) Confidence 0.45 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9650842 Disease Relevance 0.70 Pain Relevance 1.09
However, LUF6000 alone does not activate the A3 AR.
Neg (not) Positive_regulation (activate) of A3 AR
2) Confidence 0.33 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0 Pain Relevance 0.48
Interestingly, selective activation of A3 adenosine receptor (AR) subtype attenuated I/R-induced lung injury and associated apoptosis [22].
Positive_regulation (activation) of A3 adenosine receptor in lung associated with lung injury, adenocard and apoptosis
3) Confidence 0.14 Published 2007 Journal Crit Care Section Body Doc Link PMC2206506 Disease Relevance 0.83 Pain Relevance 0.13

General Comments

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