INT76199

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Context Info
Confidence 0.06
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.32
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CASP1, CEL) cytosol (CASP1, CEL) small molecule metabolic process (CEL)
intracellular (CASP1) lipid metabolic process (CEL) signal transduction (CASP1)
Anatomy Link Frequency
synovial cell 2
CASP1 (Homo sapiens)
CEL (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 12 97.44 Very High Very High Very High
aspirin 2 96.48 Very High Very High Very High
diclofenac 2 95.52 Very High Very High Very High
Potency 2 94.76 High High
COX2 2 25.00 Low Low
cytokine 2 25.00 Low Low
cOX1 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 89.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mean IC50 values (microM) for human platelet cyclooxygenase-1 and interleukin-1beta-stimulated human synovial cell cyclooxygenase-2 and cyclooxygenase-1/-2 IC50 ratio of various NSAIDs were as follows: aspirin, 3.2, 26, 0.12; diclofenac, 0.037, 0.00097, 38; etodolac, 122, 0.68, 179; ibuprofen, 3.0, 3.5, 0.86; indomethacin, 0.013, 0.044, 0.30; loxoprofen (active metabolite), 0.38, 0.12, 3.2; NS-398, 12, 0.0095, 1263; oxaprozin, 2.2, 36, 0.061; zaltoprofen, 1.3, 0.34, 3.8; respectively.
interleukin-1beta-stimulated Positive_regulation (stimulated) of cell in synovial cell associated with aspirin, cinod and diclofenac
1) Confidence 0.06 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9650852 Disease Relevance 0.15 Pain Relevance 0.61
We used human platelets cyclooxygenase-1 and interleukin-1beta-stimulated human synovial cell cyclooxygenase-2 for measuring cyclooxygenase selectivity.
interleukin-1beta-stimulated Positive_regulation (stimulated) of cell in synovial cell
2) Confidence 0.06 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9650852 Disease Relevance 0.16 Pain Relevance 0.53

General Comments

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