INT76217

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Context Info
Confidence 0.62
First Reported 1995
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.86
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Spdef) DNA binding (Spdef)
Anatomy Link Frequency
head 2
lymph nodes 1
platelets 1
Clara cells 1
ear 1
Spdef (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 30 100.00 Very High Very High Very High
Dextromethorphan 2 100.00 Very High Very High Very High
Paracetamol 10 99.76 Very High Very High Very High
Potency 3 96.24 Very High Very High Very High
Analgesic 1 84.40 Quite High
Inflammation 3 75.00 Quite High
cytokine 2 51.76 Quite High
anesthesia 14 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Advanced Or Metastatic Breast Cancer 12 99.84 Very High Very High Very High
Infection 43 99.38 Very High Very High Very High
Breast Cancer 133 99.08 Very High Very High Very High
Peritonitis 62 98.68 Very High Very High Very High
Pressure And Volume Under Development 48 98.60 Very High Very High Very High
Cancer 271 98.32 Very High Very High Very High
Pneumonia 1 91.56 High High
Convulsion 2 91.00 High High
Sepsis 2 89.52 High High
Hematemesis 1 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pseudopterosin E (PSE), a C-10 linked fucose glycoside and pseudopterosin A (PSA), a C-9 xylose glycoside isolated from the marine gorgonian Pseudopterogorgia elisabethae were both effective in reducing PMA-induced mouse ear edema when administered topically (ED50 (microg/ear) PSE(38), PSA(8)) or systemically (ED50 (mg/kg, i.p.)
Gene_expression (effective) of PSE in ear associated with pressure and volume under development
1) Confidence 0.62 Published 1998 Journal Life Sci. Section Abstract Doc Link 9651113 Disease Relevance 0.17 Pain Relevance 0.15
In support of this concept, conditional expression of SPDEF, an ETS family transcription factor, in respiratory epithelial cells of adult mice converts Clara cells into goblet cells [36].
Gene_expression (expression) of SPDEF in Clara cells
2) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Interestingly, over-expression of PSE gene had statistically significant association with ER-positive and PR-positive tumors (p = 0.0123 and p = 0.0134, respectively) and showed a trend towards pathology-negative nodal status (31% vs. 19%; Table 3).
Gene_expression (over) of PSE associated with cancer
3) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.36 Pain Relevance 0
Using the five-marker gene-panel (mam, PIP, CEA, PSE and EpCAM) at the threshold of three standard deviations above the mean expression level in normal control samples for each gene, 136 (63%) patients out of 215 were positive for at least one marker.
Gene_expression (expression) of PSE
4) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.47 Pain Relevance 0
The magnitude of the in vitro and in vivo resistance of 3 synthetic enkephalin analogs, [D-Ala2,Met5]-enkephalin (DAME), [D-Ala2,Met5]-enkephalinamide (DAME-NH2) and [D-Ala2,D-Met5]enkephalin (DADME), to 3 enkephalin-hydrolyzing enzymes, amastatin-sensitive aminopeptidase (AsA), phosphoramidon-sensitive endopeptidase-24.11 (PsE) and captopril-sensitive dipeptidyl carboxypeptidase I (CsD), was estimated by comparing the potency of enkephalins in the absence of the peptidase inhibitor (PI) with that in the presence of the PI.
Gene_expression (resistance) of PsE associated with enkephalin and potency
5) Confidence 0.13 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 12506418 Disease Relevance 0 Pain Relevance 1.67
The genes like CK19, muc1, PSE and EpCAM that show significant background expression in normal samples, loose its accuracy in tumor cell detection when Ficoll density gradient cell separation methodology is used.
Gene_expression (expression) of PSE associated with cancer
6) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.62 Pain Relevance 0
Interestingly, over-expression of PSE gene had statistically significant association with ER-positive and PR-positive tumors (p = 0.0123 and p = 0.0134, respectively) and showed a trend towards pathology-negative nodal status (31% vs. 19%; Table 3).
Gene_expression (expression) of PSE associated with cancer
7) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.36 Pain Relevance 0
Using a four-marker gene-panel (mam, PIP, CEA, and PSE) at the threshold of three standard deviations above the mean expression level in normal control samples for each gene, 19 patients (11%) out of 177 were positive.
Gene_expression (expression) of PSE
8) Confidence 0.12 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.26 Pain Relevance 0
A simple, effective, and sensitive online concentration method for the detection of dextromethorphan hydrobromide (Dex), chlorphenamine hydrogen maleate (Chl), pseudoephedrine hydrochloride (Pse) and paracetamol (Par) based on flow injection-capillary electrophoresis (FI-CE) analysis with head-column field-amplified sample stacking and large-volume sample stacking was developed.
Gene_expression (simple) of Pse in head associated with paracetamol and dextromethorphan
9) Confidence 0.11 Published 2008 Journal Anal Sci Section Abstract Doc Link 18689945 Disease Relevance 0 Pain Relevance 0.25
A simple, effective, and sensitive online concentration method for the detection of dextromethorphan hydrobromide (Dex), chlorphenamine hydrogen maleate (Chl), pseudoephedrine hydrochloride (Pse) and paracetamol (Par) based on flow injection-capillary electrophoresis (FI-CE) analysis with head-column field-amplified sample stacking and large-volume sample stacking was developed.
Gene_expression (detection) of Pse in head associated with paracetamol and dextromethorphan
10) Confidence 0.11 Published 2008 Journal Anal Sci Section Abstract Doc Link 18689945 Disease Relevance 0 Pain Relevance 0.25
For this study we selected seven breast cancer-associated genes [mam, CEA, CK19, PIP, muc1, PSE, Erb (BM only) and EpCAM (PBL only)] known to be over-expressed in metastatic breast cancer compared to control lymph nodes [31,36,37].
Gene_expression (expressed) of PSE in lymph nodes associated with breast cancer and advanced or metastatic breast cancer
11) Confidence 0.05 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2292197 Disease Relevance 0.66 Pain Relevance 0
How were the PSE values altered during the auditory blocks when sets of vocalizations were presented at the target T2?
Gene_expression (values) of PSE
12) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771902 Disease Relevance 0 Pain Relevance 0
Predictors of mortality in patients with SBP variant of ascitic fluid infection, on univariate analysis were, presence of PSE, raised creatinine, low platelets counts, increased PT.
Gene_expression (presence) of PSE in platelets associated with peritonitis and infection
13) Confidence 0.01 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2628346 Disease Relevance 1.96 Pain Relevance 0

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