INT76227

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 32.31
Pain Relevance 4.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NPC1) nuclear envelope (NPC1) endoplasmic reticulum (NPC1)
lysosome (NPC1)
Anatomy Link Frequency
plasma 1
dentate gyrus 1
external 1
lung 1
cytotoxic T cell 1
NPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 52 99.92 Very High Very High Very High
alcohol 12 99.76 Very High Very High Very High
antagonist 14 99.72 Very High Very High Very High
agonist 9 99.72 Very High Very High Very High
Pain 26 98.24 Very High Very High Very High
Inflammation 16 97.88 Very High Very High Very High
cva 16 91.60 High High
b2 receptor 6 86.00 High High
Myofascial pain syndrome 4 84.48 Quite High
Hippocampus 10 84.16 Quite High
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 2335 100.00 Very High Very High Very High
Cancer 916 99.70 Very High Very High Very High
Epstein-barr Virus 589 99.70 Very High Very High Very High
Stroke 10 98.88 Very High Very High Very High
Infection 153 98.76 Very High Very High Very High
Disease 349 98.56 Very High Very High Very High
Apoptosis 65 98.42 Very High Very High Very High
Pain 24 98.24 Very High Very High Very High
Genetic Predisposition To Disease 43 98.20 Very High Very High Very High
INFLAMMATION 16 97.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
provides evidence for the linkage of NPC to chromosome 3p and a fine map of NPC
NPC Binding (linkage) of associated with nasopharynx cancer
1) Confidence 0.41 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.16 Pain Relevance 0
In nonendemic areas, the association of NPC with alcohol and tobacco use has
NPC Binding (association) of associated with nasopharynx cancer and alcohol
2) Confidence 0.41 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.79 Pain Relevance 0.05
associated with NPC susceptibility.
NPC Binding (associated) of associated with nasopharynx cancer
3) Confidence 0.41 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.73 Pain Relevance 0
study detected a consistent association between NPC and the prevalent Chinese
NPC Binding (association) of associated with nasopharynx cancer
4) Confidence 0.41 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.77 Pain Relevance 0
provides evidence for the linkage of NPC to chromosome 3p and a fine map of NPC
NPC Binding (map) of associated with nasopharynx cancer
5) Confidence 0.36 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.15 Pain Relevance 0
While a reduced risk for NPC
NPC Binding (risk) of associated with nasopharynx cancer
6) Confidence 0.32 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.81 Pain Relevance 0
been shown to be associated with a significantly increased risk for NPC.
NPC Binding (associated) of associated with nasopharynx cancer
7) Confidence 0.32 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.88 Pain Relevance 0
NPC tumorigenesis may be through its cytotoxic T cell recognition and host immune
NPC Binding (recognition) of in cytotoxic T cell associated with nasopharynx cancer
8) Confidence 0.32 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.95 Pain Relevance 0
demonstrated an increased risk of NPC for individuals with HLA-A2.
NPC Binding (risk) of associated with nasopharynx cancer
9) Confidence 0.32 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.80 Pain Relevance 0
Most of the linkage studies on NPC performed so far have used
NPC Binding (linkage) of associated with nasopharynx cancer
10) Confidence 0.32 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.53 Pain Relevance 0
The results of immunoprecipitation suggested a direct interaction between EBNA-5 and p63 protein in NPC, and this binding would increase the stability of p63.
NPC Spec (suggested) Binding (interaction) of associated with nasopharynx cancer
11) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.27 Pain Relevance 0
Three subtypes of NPC are recognized in the World Health Organization (WHO) classification: 1) squamous cell carcinoma, typically found in the older adult population; 2) non-keratinizing carcinoma; 3) undifferentiated carcinoma.
NPC Binding (recognized) of associated with nasopharynx cancer, carcinoma and skin cancer
12) Confidence 0.32 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1559589 Disease Relevance 1.49 Pain Relevance 0.05
The reduced risk of NPC associated
NPC Binding (associated) of associated with nasopharynx cancer
13) Confidence 0.31 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.78 Pain Relevance 0
It has also been found that EBV is especially associated with less differentiated forms of NPC.
NPC Binding (associated) of associated with nasopharynx cancer and epstein-barr virus
14) Confidence 0.29 Published 2006 Journal Virol J Section Body Doc Link PMC1388193 Disease Relevance 1.95 Pain Relevance 0
The patient had a history of NPC one year previously, and had received a complete radiation therapy course (total dose of 6500 Gy), without chemotherapy.
NPC Binding (history) of associated with nasopharynx cancer
15) Confidence 0.28 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC3019583 Disease Relevance 1.49 Pain Relevance 0.05
This paper is intended to: (1) alert the general dentist of the signs and symptoms associated with NPC, such that timely and appropriate treatment may ensue; (2) provide a basic outline for assessment, preparation, palliation and continuing care of a patient diagnosed with NPC; and (3) underline the significant role of the general dentist in achieving an optimal quality of life for these patients
NPC Binding (associated) of associated with nasopharynx cancer
16) Confidence 0.28 Published 2000 Journal Oral Oncol. Section Abstract Doc Link 10964045 Disease Relevance 1.26 Pain Relevance 0.37
For patients with extensive disease requiring external radiotherapy, superior dose distribution and organ sparing have been demonstrated with IMRT over more conventional conformal radiation delivery techniques for salvage of NPC.
NPC Binding (salvage) of in external associated with nasopharynx cancer and disease
17) Confidence 0.28 Published 2010 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2966947 Disease Relevance 0.67 Pain Relevance 0
Moreover, a locus on 3p21 was identified to link to NPC in a linkage analysis [9].
NPC Binding (link) of associated with nasopharynx cancer
18) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.48 Pain Relevance 0
Loss of DAPK expression was shown to be associated with promoter region methylation in NPC.
NPC Binding (associated) of associated with nasopharynx cancer
19) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.38 Pain Relevance 0
In the era of molecular targeted therapy, specific treatment to the potential target using technologies such as immunotherapy and RNAi becomes formulating from bench to bedside application and thus makes molecular biomarker discovery more meaningful for NPC management.



NPC Binding (management) of associated with nasopharynx cancer
20) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 0.80 Pain Relevance 0

General Comments

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