INT7623

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Context Info
Confidence 0.44
First Reported 1983
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 1.31
Pain Relevance 5.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
adrenal medulla 3
brain 3
spinal 2
eye 2
PVN 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Locus ceruleus 3 100.00 Very High Very High Very High
monoamine 3 100.00 Very High Very High Very High
Hippocampus 7 99.48 Very High Very High Very High
qutenza 2 99.36 Very High Very High Very High
Neuropeptide 1 99.36 Very High Very High Very High
medulla 17 99.00 Very High Very High Very High
Morphine 21 98.64 Very High Very High Very High
withdrawal 16 98.20 Very High Very High Very High
Kinase C inhibitor 1 96.24 Very High Very High Very High
addiction 3 95.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Toxocariasis 10 100.00 Very High Very High Very High
Ganglion Cysts 4 85.56 High High
Opiate Addiction 1 76.68 Quite High
Convulsion 1 75.16 Quite High
Decapitation 1 51.92 Quite High
Attention Deficit Hyperactivity Disorder 1 46.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of MTZ on c-fos, PPenk, and TH mRNAs were dose dependent in both adrenal and hippocampus.
Regulation (dependent) of Regulation (dependent) of TH in hippocampus associated with hippocampus
1) Confidence 0.44 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8102782 Disease Relevance 0.08 Pain Relevance 0.26
Alteration in the histochemical presence of tyrosine hydroxylase and CGRP-immunoreactivities in the eye following chronic sympathetic or sensory denervation.
Regulation (presence) of Regulation (immunoreactivities) of tyrosine hydroxylase in eye associated with qutenza
2) Confidence 0.27 Published 1988 Journal Curr. Eye Res. Section Title Doc Link 2903010 Disease Relevance 0 Pain Relevance 0.28
This study was undertaken to investigate the effects of the administration of 3,4-methylenedioxymethamphetamine (MDMA) on the locus coeruleus firing rate, on the sensitivity of the alpha(2)-adrenoceptors which regulate neuronal activity and on the in vivo tyrosine hydroxylase activity in hippocampus.
Spec (investigate) Regulation (effects) of Regulation (sensitivity) of tyrosine hydroxylase in locus coeruleus associated with locus ceruleus and hippocampus
3) Confidence 0.26 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12536039 Disease Relevance 0 Pain Relevance 0.32
Additionally, the changes in TH levels in the PVN and NTS/VLM were significantly modified by calphostin C.
Regulation (modified) of Regulation (changes) of TH in PVN associated with toxocariasis
4) Confidence 0.23 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16190878 Disease Relevance 0.43 Pain Relevance 1.50
It is possible that an alpha-adrenergic system participates in the regulation of tyrosine hydroxylase activity in the adrenal medulla.
Regulation (participates) of Regulation (regulation) of tyrosine hydroxylase in adrenal medulla associated with medulla
5) Confidence 0.22 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6133231 Disease Relevance 0 Pain Relevance 0.32
The role of spinal pathways in the regulation of tyrosine hydroxylase activity (ATHA) in the adrenal medulla was characterized in adult rats with surgical transection of the upper thoracic cord.
Regulation (role) of in adrenal medulla Regulation (regulation) of tyrosine hydroxylase in upper associated with medulla
6) Confidence 0.22 Published 1983 Journal Neuropharmacology Section Abstract Doc Link 6133231 Disease Relevance 0 Pain Relevance 0.28
Participation of spinal monoaminergic and cholinergic systems in the regulation of adrenal tyrosine hydroxylase.
Regulation (Participation) of Regulation (regulation) of tyrosine hydroxylase in spinal associated with monoamine
7) Confidence 0.22 Published 1983 Journal Neuropharmacology Section Title Doc Link 6133231 Disease Relevance 0 Pain Relevance 0.34
The stimulatory effects of low-Na+ medium on DOPA production and on tyrosine hydroxylase activity in vitro were dependent on extra-cellular Ca2+.
Regulation (dependent) of Regulation (effects) of tyrosine hydroxylase
8) Confidence 0.22 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857766 Disease Relevance 0.30 Pain Relevance 0.17
Furthermore, the changes in TH immunoreactivity were significantly modified by infusion of HA-1004.
Regulation (changes) of Regulation (immunoreactivity) of TH
9) Confidence 0.19 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15663473 Disease Relevance 0.45 Pain Relevance 1.46
Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway, Brain Res.
Regulation (regulate) of Regulation (regulation) of tyrosine hydroxylase in Brain
10) Confidence 0.17 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0
The physiological importance of brain alpha 2-adrenoceptors in controlling the activity of tyrosine hydroxylase in noradrenergic regions was investigated using the accumulation of 3,4-dihydroxyphenylalanine (DOPA) after decarboxylase inhibition as a measure of the rate of tyrosine hydroxylation (and synthesis of noradrenaline) in vivo.
Regulation (importance) of Regulation (controlling) of tyrosine hydroxylase in brain associated with noradrenaline
11) Confidence 0.12 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1353254 Disease Relevance 0.05 Pain Relevance 0.22
We have demonstrated that there are differential changes in the levels of tyrosine hydroxylase (TH), phenylethanolamine N-methyltransferase (PNMT), and proenkephalin A (Pro Enk A) mRNA in the fetal sheep adrenal during late gestation.
Regulation (changes) of Regulation (changes) of tyrosine hydroxylase
12) Confidence 0.07 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9648889 Disease Relevance 0 Pain Relevance 0

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