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Context Info
Confidence 0.41
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.45
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Psma4) nucleus (Psma4) cytoplasm (Psma4)
Anatomy Link Frequency
hippocampus 1
Psma4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 4 98.36 Very High Very High Very High
withdrawal 20 97.46 Very High Very High Very High
Dismenorea 2 86.56 High High
Pyramidal cell 2 76.64 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 4 98.76 Very High Very High Very High
Substance Withdrawal Syndrome 2 68.92 Quite High
Reprotox - General 1 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Withdrawal from 3alpha-OH-5alpha-pregnan-20-One using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association with increased anxiety.
Positive_regulation (increases) of alpha4 subunit associated with anxiety disorder and withdrawal
1) Confidence 0.41 Published 1998 Journal J. Neurosci. Section Title Doc Link 9651210 Disease Relevance 0.25 Pain Relevance 0.36
These changes were also associated with significant two and threefold increases in both the mRNA and protein for the alpha4 subunit of the GABAA receptor, respectively, in hippocampus.
Positive_regulation (increases) of alpha4 subunit in hippocampus associated with hippocampus
2) Confidence 0.30 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651210 Disease Relevance 0.20 Pain Relevance 0.52

General Comments

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