INT7624

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2006
Negated 0
Speculated 2
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.41
Pain Relevance 7.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
VLM 6
ventricle 2
middle cerebral artery 2
brain 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
medulla 11 100.00 Very High Very High Very High
Neuropeptide 10 100.00 Very High Very High Very High
withdrawal 35 99.98 Very High Very High Very High
Enkephalin 3 99.92 Very High Very High Very High
Morphine 42 99.76 Very High Very High Very High
Kinase C 9 99.26 Very High Very High Very High
noradrenaline 8 98.64 Very High Very High Very High
narcan 11 94.04 High High
addiction 5 93.68 High High
Opioid 2 88.92 High High
Disease Link Frequency Relevance Heat
Toxocariasis 14 100.00 Very High Very High Very High
Infarction 1 98.20 Very High Very High Very High
Middle Cerebral Artery Infarction 3 97.52 Very High Very High Very High
Pheochromocytoma 4 94.72 High High
Opiate Addiction 2 89.36 High High
Attention Deficit Hyperactivity Disorder 3 86.00 High High
Stroke 4 70.56 Quite High
Injury 1 68.48 Quite High
Morphine Dependence 1 65.08 Quite High
Decapitation 1 51.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results support the hypothesis that the full response of the TH gene to cyclic AMP requires both the canonical TH CRE and this newly discovered element, which we term TH CRE2.
Positive_regulation (requires) of Regulation (response) of TH gene
1) Confidence 0.50 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595476 Disease Relevance 0.06 Pain Relevance 0
Recently, we have shown increases in the immunoreactivity for neuropeptide Y and tyrosine hydroxylase in the insular cortex surrounding the focal infarction after middle cerebral artery occlusion.
Positive_regulation (increases) of Regulation (immunoreactivity) of tyrosine hydroxylase in middle cerebral artery associated with middle cerebral artery infarction, neuropeptide and infarction
2) Confidence 0.48 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 9331169 Disease Relevance 0.46 Pain Relevance 0.36
The response of the tyrosine hydroxylase gene to cyclic AMP is mediated by two cyclic AMP-response elements.
Positive_regulation (mediated) of Regulation (response) of tyrosine hydroxylase associated with enkephalin
3) Confidence 0.46 Published 1995 Journal J. Neurochem. Section Title Doc Link 7595476 Disease Relevance 0.17 Pain Relevance 0.10
TH immunoreactivity was increased in the NTS/VLM after induction of morphine withdrawal, whereas there was a decrease in TH levels in the PVN.
Positive_regulation (increased) of Regulation (immunoreactivity) of TH in VLM associated with toxocariasis, withdrawal and morphine
4) Confidence 0.40 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16190878 Disease Relevance 0.51 Pain Relevance 1.63
TH immunoreactivity in the NTS/VLM was increased 90 min after morphine withdrawal, whereas there was a decrease in TH levels in the PVN at the same time point.
Positive_regulation (increased) of Regulation (immunoreactivity) of TH in VLM associated with toxocariasis, withdrawal and morphine
5) Confidence 0.40 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12534973 Disease Relevance 0.54 Pain Relevance 1.59
TH immunoreactivity in NTS/VLM was increased 90 min after induction of morphine withdrawal, whereas there was a decrease in TH levels in the PVN at the same time point.
Positive_regulation (increased) of Regulation (immunoreactivity) of TH in VLM associated with medulla, withdrawal and morphine
6) Confidence 0.32 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15663473 Disease Relevance 0.53 Pain Relevance 1.67
The physiological importance of brain alpha 2-adrenoceptors in controlling the activity of tyrosine hydroxylase in noradrenergic regions was investigated using the accumulation of 3,4-dihydroxyphenylalanine (DOPA) after decarboxylase inhibition as a measure of the rate of tyrosine hydroxylation (and synthesis of noradrenaline) in vivo.
Spec (investigated) Positive_regulation (importance) of Regulation (controlling) of tyrosine hydroxylase in brain associated with noradrenaline
7) Confidence 0.21 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1353254 Disease Relevance 0.05 Pain Relevance 0.22
The present study was designed to investigate the role of protein kinase C (PKC) in this process, by estimating whether pharmacological inhibition of PKC would attenuate morphine withdrawal induced Fos expression and changes in tyrosine hydroxylase (TH) immunoreactivity levels and NA turnover in the left and right ventricle.
Spec (whether) Positive_regulation (induced) of Regulation (changes) of tyrosine hydroxylase in ventricle associated with kinase c, noradrenaline, withdrawal and morphine
8) Confidence 0.05 Published 2006 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 16474935 Disease Relevance 0.09 Pain Relevance 1.43

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