INT76240

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 6.04
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lif) extracellular region (Lif)
Anatomy Link Frequency
skin 2
spermatocytes 1
Lif (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 179 100.00 Very High Very High Very High
Inflammation 36 99.48 Very High Very High Very High
rheumatoid arthritis 124 99.28 Very High Very High Very High
Nerve growth factor 9 98.04 Very High Very High Very High
Hyperalgesia 3 95.12 Very High Very High Very High
antagonist 3 89.12 High High
imagery 1 82.40 Quite High
Inflammatory response 18 80.96 Quite High
Analgesic 7 75.00 Quite High
Arthritis 6 75.00 Quite High
Disease Link Frequency Relevance Heat
Leukemia 14 100.00 Very High Very High Very High
Dermatitis 3 99.68 Very High Very High Very High
Rheumatoid Arthritis 127 99.28 Very High Very High Very High
INFLAMMATION 48 99.24 Very High Very High Very High
Body Weight 1 98.80 Very High Very High Very High
Calcification 1 96.88 Very High Very High Very High
Hypersensitivity 3 96.76 Very High Very High Very High
Spondylolisthesis 6 95.12 Very High Very High Very High
Hyperalgesia 3 95.12 Very High Very High Very High
Obesity 2 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signaling molecule, is elevated during skin inflammation produced by intraplantar injection of complete Freund's adjuvant (CFA).
Positive_regulation (elevated) of LIF in skin associated with leukemia, inflammation and dermatitis
1) Confidence 0.69 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651226 Disease Relevance 0.58 Pain Relevance 0.33
These data show that upregulation of LIF during peripheral inflammation serves a key, early anti-inflammatory role and that exogenous LIF can reduce inflammatory hyperalgesia.
Positive_regulation (upregulation) of LIF associated with hyperalgesia and inflammation
2) Confidence 0.69 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651226 Disease Relevance 0.95 Pain Relevance 0.61
The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signaling molecule, is elevated during skin inflammation produced by intraplantar injection of complete Freund's adjuvant (CFA).
Positive_regulation (elevated) of leukemia inhibitory factor in skin associated with leukemia, inflammation and dermatitis
3) Confidence 0.69 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9651226 Disease Relevance 0.58 Pain Relevance 0.33
Recent studies suggest that some of the IL-6 family cytokines such as IL-6, IL-11, and LIF could be related with RA.
Positive_regulation (some) of LIF associated with rheumatoid arthritis and cytokine
4) Confidence 0.37 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 1.11 Pain Relevance 0.76
At a systemic level, excess Lif has been associated with low body weight, hypermotility, overgrowth of bone, calcification of several organs, loss of spermatocytes in males and severe loss of adipose tissue [44], and in the liver specifically, Lif has been found to stimulate triglyceride secretion [45].
Positive_regulation (excess) of Lif in spermatocytes associated with calcification, body weight and obesity
5) Confidence 0.34 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2094713 Disease Relevance 0.79 Pain Relevance 0.07
The current study showed that serum concentrations of IL-6, IL-11, and LIF were significantly elevated in patients with RA compared to those in healthy controls.
Positive_regulation (elevated) of LIF associated with rheumatoid arthritis
6) Confidence 0.30 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017685 Disease Relevance 0.73 Pain Relevance 0.47
While the example shown is a GO-LIF fixation at the L5/S1 level, GO-LIF can be performed at all lumbar levels.
Positive_regulation (performed) of GO-LIF
7) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2944216 Disease Relevance 0.18 Pain Relevance 0.04
Serum concentrations of IL-6 family cytokines, including IL-6, IL-11, and LIF, were significantly elevated in patients with RA compared to those of healthy controls.
Positive_regulation (elevated) of LIF associated with rheumatoid arthritis and cytokine
8) Confidence 0.15 Published 2011 Journal Yonsei Medical Journal Section Abstract Doc Link PMC3017685 Disease Relevance 1.12 Pain Relevance 0.51

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