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Context Info
Confidence 0.34
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.34
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) DNA binding (Fos) response to stress (Fos)
extracellular space (Tac1) extracellular region (Tac1) nucleolus (Fos)
Anatomy Link Frequency
locus coeruleus 2
Tac1 (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 4 99.44 Very High Very High Very High
Locus ceruleus 8 96.60 Very High Very High Very High
substance P 1 75.00 Quite High
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 4 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the enhanced c-fos expression observed in response to tachykinin NK1 receptor antagonists combined with stress, could be due to the blockade of tachykinin NK1 receptor-mediated activity at sites other than the locus coeruleus, resulting in an overall activation of the locus coeruleus.
tachykinin Positive_regulation (enhanced) of Gene_expression (expression) of c-fos in locus coeruleus associated with stress, locus ceruleus and antagonist
1) Confidence 0.34 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652329 Disease Relevance 0.34 Pain Relevance 0.56

General Comments

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