INT76249

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Context Info
Confidence 0.75
First Reported 1998
Last Reported 2010
Negated 4
Speculated 4
Reported most in Body
Documents 67
Total Number 71
Disease Relevance 15.07
Pain Relevance 22.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Anatomy Link Frequency
hippocampus 5
synapses 5
neurons 4
retina 3
dorsal horn 3
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 1389 100.00 Very High Very High Very High
Glutamate receptor 537 100.00 Very High Very High Very High
antagonist 71 100.00 Very High Very High Very High
addiction 34 100.00 Very High Very High Very High
Central nervous system 91 99.96 Very High Very High Very High
Pyramidal cell 669 99.84 Very High Very High Very High
long-term potentiation 624 99.84 Very High Very High Very High
amygdala 66 99.84 Very High Very High Very High
Central grey 155 99.68 Very High Very High Very High
spinal dorsal horn 71 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Respiratory Failure 2 99.96 Very High Very High Very High
Urological Neuroanatomy 161 99.68 Very High Very High Very High
INFLAMMATION 180 99.48 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

7 99.40 Very High Very High Very High
Injury 84 98.96 Very High Very High Very High
Depression 496 98.84 Very High Very High Very High
Targeted Disruption 474 98.80 Very High Very High Very High
Anxiety Disorder 273 98.60 Very High Very High Very High
Inflammatory Pain 123 98.50 Very High Very High Very High
Convulsion 331 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GluR1-containing AMPA receptors are highly expressed in rodent brain regions mediating fear learning including the amygdala and hippocampus (McDonald, 1996; Zamanillo et al., 1999).
Gene_expression (expressed) of GluR1-containing in hippocampus associated with anxiety disorder, hippocampus and amygdala
1) Confidence 0.75 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525858 Disease Relevance 0.55 Pain Relevance 0.20
These data indicate that rod photoreceptor-mediated visual input may have a negative effect on GluR1 expression in normal retina during the course of development.
Gene_expression (expression) of GluR1 in photoreceptor
2) Confidence 0.68 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.07
The demonstration that GluR1 expression is increased in the retina of the rdta mouse where a rod photoreceptor-mediated visual input is missing is consistent with a previous report in which the level of GluR1 is increased in the deafferented tectum [64,65].
Gene_expression (expression) of GluR1 in tectum
3) Confidence 0.68 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.07
However, changes in GluR1 gene expression are not evident in the retinae of rd mice [66] using the in situ hybridization method [67].
Gene_expression (expression) of GluR1
4) Confidence 0.68 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.07
-32P-ATP labeling of GluR1 by this procedure was greater in the retinae of control mice than in the retina of the rdta mice (Figure 4A), whereas the expression of GluR1 was increased in the rdta mice relative to their littermate controls (Figure 4B).
Gene_expression (expression) of GluR1 in retina
5) Confidence 0.68 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
In contrast to previous observations that the AMPA receptor expression is relatively constant in glutamate sensitive neurons [26], recent studies have shown that the expression of AMPA receptor subunits, especially GluR1, the major functional subunit of the AMPA receptor [11] is regulated developmentally at regional, cellular, and synaptic levels [27,28,29,30].
Gene_expression (expression) of GluR1 in neurons associated with glutamate
6) Confidence 0.68 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0.05 Pain Relevance 0.32
In the present study, an increased synaptic expression of the NMDA receptors and GluR1 subunits is associated with changes in CaMKII.
Gene_expression (expression) of GluR1 associated with nmda receptor
7) Confidence 0.68 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.08
Although we did not determine the percentage of glutamatergic synapses that expressed GluR1 in our previous study [33] we did estimate that this subunit was present at 30–40% of synapses associated with terminals that contained VGLUT1 or were derived from unmyelinated primary afferents in laminae I–II, and at ~15% of the synapses formed by VGLUT2-containing boutons in these laminae.
Gene_expression (expressed) of GluR1 in synapses associated with unmyelinated
8) Confidence 0.67 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.09
Thus, our experiments using GluA1/2 KO mice suggest that the AMPA receptor subunits, GluA1 and GluA2, act differentially in ACC LTP.


Gene_expression (act) of GluA1 associated with long-term potentiation and anterior cingulate cortex
9) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.08 Pain Relevance 0.60
GluA1 and GluA2 subunits in cortical LTP
Gene_expression (subunits) of GluA1 associated with long-term potentiation
10) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.50
However, in the ACC, using postsynaptic injection of different peptide inhibitors Toyoda et al found that GluA1 contribute to LTP in the layer II/III pyramidal neurons [29].
Gene_expression (contribute) of GluA1 in pyramidal neurons associated with pyramidal cell, long-term potentiation and anterior cingulate cortex
11) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.13 Pain Relevance 0.63
For example, in the hippocampal CA1 region, GluA1 is required for LTP in adult but not juvenile animals [25,27].
Gene_expression (required) of GluA1 in juvenile associated with long-term potentiation
12) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.11 Pain Relevance 0.67
NMDA receptor-mediated EPSCs in the ACC pyramidal neurons remained unchanged in GluA1-/- (n = 8) mice in comparison with WT mice (n = 6, Fig. 3A, left).
Neg (unchanged) Gene_expression (unchanged) of GluA1 in pyramidal neurons associated with pyramidal cell, nmda receptor and anterior cingulate cortex
13) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.70
Present data predict that loss of GluR1 function in amygdala neurons would cause deficits in other cognitive tasks mediated by this brain region.
Gene_expression (function) of GluR1 in neurons associated with cognitive disorder and amygdala
14) Confidence 0.65 Published 2007 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2525858 Disease Relevance 0.35 Pain Relevance 0.25
Immunoprecipitation of GluR1
Gene_expression (Immunoprecipitation) of GluR1
15) Confidence 0.59 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0
Because GluR1 is a known substrate of CaMKII in vitro and in vivo [34,36,37,38,39,40] and because CaMKII expression/activity is up-regulated in the retinae of the rdta mice [34], GluR1 phosphorylation might also be increased in the rodless retina.
Gene_expression (expression) of GluR1 in retina
16) Confidence 0.59 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.04
We found that fluoxetine treatment increased expression of phosphosynapsin, PSD-95 and synaptic GluR1 (but not total GluR1) in the hippocampus of ovariectomized but not sham rats.
Gene_expression (expression) of GluR1 in hippocampus associated with hippocampus and fluoxetine
17) Confidence 0.58 Published 2009 Journal Psychoneuroendocrinology Section Abstract Doc Link 18977602 Disease Relevance 0.07 Pain Relevance 0.77
This seems very unlikely since in the hippocampus staining with this antibody is restricted to the dendrites of interneurons, and is not seen on pyramidal cells, which express GluR1, 2 and 3 subunits (M.W. unpublished observations).
Gene_expression (express) of GluR1 in interneurons associated with pyramidal cell and hippocampus
18) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.10
Approximately 10% of the pan-AMPAr-positive puncta in laminae I–III in these sections were not immunostained with either GluR1 or GluR3 antibodies (Table 2).
Gene_expression (antibodies) of GluR1
19) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.03
From each section, 400 pan-AMPAr-labelled puncta were selected (100 each from laminae I, IIo, IIi and III) and these were then examined to determine whether they were immunoreactive with the GluR1, GluR3 or GluR4 antibodies.
Gene_expression (antibodies) of GluR1
20) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2248168 Disease Relevance 0 Pain Relevance 0.08

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