INT76253

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 29
Total Number 31
Disease Relevance 13.99
Pain Relevance 7.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY2) aging (P2RY2) plasma membrane (P2RY2)
embryo development (P2RY2) lysosome (P2RY2) signal transducer activity (P2RY2)
Anatomy Link Frequency
Microglia 3
smooth muscle 1
nerve 1
peripheral nerve 1
fibroblasts 1
P2RY2 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 121 100.00 Very High Very High Very High
Chronic pancreatitis 9 99.64 Very High Very High Very High
agonist 100 99.60 Very High Very High Very High
antagonist 177 99.50 Very High Very High Very High
Sumatriptan 3 99.48 Very High Very High Very High
Neuropathic pain 16 99.02 Very High Very High Very High
Pain 54 98.84 Very High Very High Very High
Potency 34 98.04 Very High Very High Very High
Kinase C 7 97.52 Very High Very High Very High
Peripheral nervous system 4 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 188 99.98 Very High Very High Very High
Injury 189 99.72 Very High Very High Very High
Pancreatitis 18 99.64 Very High Very High Very High
Bordatella Infection 2 99.56 Very High Very High Very High
Pancreatic Cancer 12 99.36 Very High Very High Very High
Wound Healing 92 99.34 Very High Very High Very High
Neuropathic Pain 28 99.02 Very High Very High Very High
Pain 43 98.84 Very High Very High Very High
Nociception 29 98.28 Very High Very High Very High
Neointima 15 97.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present work, it seems clear that wound healing effect evoked by Ap4A is due to activation of P2Y2-R.
Positive_regulation (activation) of P2Y2-R associated with wound healing
1) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.87 Pain Relevance 0
It has been tentatively suggested that the activation of P2Y2 receptors accelerates the rate of corneal epithelial cell migration while the stimulation of a P2Y6 does the opposite [6].
Positive_regulation (activation) of P2Y2 in corneal epithelial cell
2) Confidence 0.70 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.61 Pain Relevance 0.07
P2Y2 was markedly upregulated in biopsies of pancreatic cancer tissues and expressed by fibroblasts adjacent to tumors.
Positive_regulation (upregulated) of P2Y2 in fibroblasts associated with cancer and pancreatic cancer
3) Confidence 0.60 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.54 Pain Relevance 0.43
Staining for P2Y2 receptor was reduced in cells incubated with both P2Y2-R siRNA #1 (data not shown) and P2Y2-R siRNA #2 transfected cells.
Positive_regulation (Staining) of P2Y2
4) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.16 Pain Relevance 0.04
These results indicate that silencing P2Y2-R in our model was detected 24 h after the wound was performed.
Positive_regulation (silencing) of P2Y2-R associated with injury
5) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.71 Pain Relevance 0
Transcripts of ectonucleotidases (CD39 and CD39L1) together with P2R (P2X7, P2Y2, and P2Y6) are significantly increased in both chronic pancreatitis and pancreatic cancer.
Positive_regulation (increased) of P2R associated with pancreatic cancer and chronic pancreatitis
6) Confidence 0.46 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.44 Pain Relevance 0.43
Immunogold electron microscopic observations of HA-A1R and Myc-P2Y2R expressed in HEK293T cells
Positive_regulation (observations) of P2Y2R
7) Confidence 0.46 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.10
Also, the simultaneous activation of endogenous A1R and P2Y2R in DDT1MF-2 cells synergistically increases translocation of protein kinase C [7].
Positive_regulation (activation) of P2Y2R associated with kinase c
8) Confidence 0.42 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.15
Finally, sumatriptan synergistically enhanced P2U purinoceptor stimulated [3H]inositol phosphate accumulation through a pertussis toxin-sensitive mechanism.
Positive_regulation (accumulation) of P2U purinoceptor associated with sumatriptan and bordatella infection
9) Confidence 0.42 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652344 Disease Relevance 0.19 Pain Relevance 0.35
This is consistent with the activation of the human P2Y2 receptor (17) because ATP acts as a competitive antagonist on the human P2Y4 receptor (18).
Positive_regulation (activation) of P2Y2 associated with antagonist
10) Confidence 0.34 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671790 Disease Relevance 0.21 Pain Relevance 0.13
Intracellular Ca2+ levels in response to P2Y receptor agonists were monitored as changes in fluorescence intensity using a Fluorescent Light Imaging Plate Reader (FLIPR) from Molecular Devices (Sunnyvale, CA).
Positive_regulation (response) of P2Y associated with agonist and imagery
11) Confidence 0.25 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096529 Disease Relevance 0.13 Pain Relevance 0.16
Interestingly, P2Y2 stimulation mediated greater inhibition of TNF?
Positive_regulation (stimulation) of P2Y2
12) Confidence 0.24 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0.11
This was confirmed at the mRNA level where P2Y2 receptors were found to be upregulated, while P2X1 receptors were downregulated [145].
Positive_regulation (upregulated) of P2Y2
13) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.75 Pain Relevance 0.04
Upregulation of P2Y1 and P2Y2 receptors and downregulation of P2X1 receptors on smooth muscle of varicose veins is associated with a shift from contractile to synthetic and/or proliferative roles; this phenotypic change in smooth muscle leads to weakening of vein walls and may be a causal factor in the development of varicose veins [158], an interesting parallel to the receptor changes seen in response to increased shear stress (see above) [151].


Positive_regulation (Upregulation) of P2Y2 in smooth muscle associated with stress and increased venous pressure under development
14) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.82 Pain Relevance 0.03
Thus, factors of importance in the development of vascular disease increase mitogenic P2Y2 receptors; this is further supported by their upregulation in neointima after balloon angioplasty [148, 149].
Positive_regulation (increase) of mitogenic P2Y2 associated with neointima and increased venous pressure under development
15) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.54 Pain Relevance 0.05
Transcripts of ectonucleotidases (CD39 and CD39L1) together with P2R (P2X7, P2Y2, and P2Y6) are significantly increased in both chronic pancreatitis and pancreatic cancer.
Positive_regulation (increased) of P2Y2 associated with pancreatic cancer and chronic pancreatitis
16) Confidence 0.20 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.43 Pain Relevance 0.43
In a complex neural tissue, such as the human peripheral nerve trunk, ATP may activate P2X, P2Y, and adenosine receptors present on various cell types.
Spec (may) Positive_regulation (activate) of P2Y in peripheral nerve trunk associated with adenocard
17) Confidence 0.19 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 12382074 Disease Relevance 0.19 Pain Relevance 0.44
The data suggest that ATP-induced changes in axonal excitability and of [Ca(2+)](i) result from activation of adenosine A2, A1 and P2Y nucleotide receptors in human nerve; a contribution of P2X receptors was not found with the methods used.
Positive_regulation (activation) of P2Y in nerve associated with adenocard
18) Confidence 0.19 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 12382074 Disease Relevance 0.08 Pain Relevance 0.53
Microglia play a key role in neuropathic pain, chemotaxis and phagocytosis through nucleotide-evoked activation of P2X(4), P2Y(12) and P2Y(6) receptors, respectively.
Positive_regulation (activation) of P2Y in Microglia associated with neuropathic pain
19) Confidence 0.18 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18563292 Disease Relevance 0.10 Pain Relevance 0.10
Microglia play a key role in neuropathic pain, chemotaxis and phagocytosis through nucleotide-evoked activation of P2X(4), P2Y(12) and P2Y(6) receptors, respectively.
Positive_regulation (activation) of P2Y in Microglia associated with neuropathic pain
20) Confidence 0.18 Published 2008 Journal Cell. Mol. Life Sci. Section Abstract Doc Link 18563292 Disease Relevance 0.10 Pain Relevance 0.10

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