INT76254

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADORA1) endoplasmic reticulum (ADORA1) plasma membrane (ADORA1)
cell-cell signaling (ADORA1) signal transducer activity (ADORA1)
ADORA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 74 100.00 Very High Very High Very High
Inflammation 85 98.08 Very High Very High Very High
agonist 5 81.16 Quite High
methotrexate 50 74.56 Quite High
Arthritis 4 69.20 Quite High
cytokine 10 65.12 Quite High
Sumatriptan 3 47.28 Quite Low
antagonist 6 37.20 Quite Low
rheumatoid arthritis 4 14.56 Low Low
Inflammatory response 3 10.32 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 85 98.08 Very High Very High Very High
Disease 4 94.52 High High
Targeted Disruption 46 73.68 Quite High
Arthritis 3 70.24 Quite High
Bordatella Infection 2 33.84 Quite Low
Experimental Arthritis 2 30.76 Quite Low
Cancer 3 27.36 Quite Low
Necrosis 4 26.88 Quite Low
Rheumatoid Arthritis 4 14.56 Low Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, co-activation of the adenosine A1 receptor (but not the 5-HT1B receptor) potentiates the hydrolysis of inositol phospholipids elicited by receptors coupled to Gq-proteins (Dickenson and Hill, 1996.
Positive_regulation (potentiates) of Positive_regulation (activation) of adenosine A1 receptor associated with adenocard
1) Confidence 0.43 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652344 Disease Relevance 0 Pain Relevance 0.09
We therefore conclude it is probable that the requirement for activation of multiple adenosine receptor subtypes in the pharmacologic control of chronic inflammation results from the involvement of different types of inflammatory cells and disease-specific differences in the inflammatory environment.


Positive_regulation (requirement) of Positive_regulation (activation) of adenosine receptor associated with adenocard, inflammation and disease
2) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.27 Pain Relevance 1.05

General Comments

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