INT76255

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 2.51
Pain Relevance 6.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADORA1) endoplasmic reticulum (ADORA1) plasma membrane (ADORA1)
cell-cell signaling (ADORA1) signal transducer activity (ADORA1)
Anatomy Link Frequency
macrophages 1
trigeminal ganglia 1
neuronal 1
monocytes 1
sympathetic 1
ADORA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
adenocard 585 100.00 Very High Very High Very High
antagonist 131 100.00 Very High Very High Very High
cytokine 36 99.80 Very High Very High Very High
Inflammation 257 99.60 Very High Very High Very High
dopamine receptor 1 98.68 Very High Very High Very High
opioid receptor 9 98.40 Very High Very High Very High
substance P 1 96.56 Very High Very High Very High
analgesia 1 95.72 Very High Very High Very High
withdrawal 1 95.52 Very High Very High Very High
Morphine 6 94.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 260 99.60 Very High Very High Very High
Glioma 8 97.76 Very High Very High Very High
Neuroblastoma 8 97.50 Very High Very High Very High
Substance Withdrawal Syndrome 1 95.52 Very High Very High Very High
Respiratory Failure 3 90.44 High High
Death 3 76.68 Quite High
Injury 6 57.72 Quite High
Necrosis 12 55.56 Quite High
Bordatella Infection 2 25.00 Low Low
Hypoglycemia 2 23.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we have demonstrated the novel finding that abundant expression of the adenosine A1, receptor protein occurs in the trigeminal ganglia, which may be suggestive of a role of this receptor in analgesia.
Gene_expression (expression) of adenosine A1 in trigeminal ganglia associated with adenocard and analgesia
1) Confidence 0.78 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11137765 Disease Relevance 0 Pain Relevance 0.33
We hypothesized that localized forearm adenosine receptor blockade would attenuate muscle sympathetic nerve activity (MSNA) responses to fatiguing handgrip exercise in humans.
Gene_expression (blockade) of adenosine receptor in sympathetic associated with adenocard
2) Confidence 0.67 Published 2010 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 20400689 Disease Relevance 0 Pain Relevance 0.23
We have previously reported that the transfected Gi/Go protein-coupled human adenosine A1 receptor (expressed at 200 fmol/mg of protein) and the endogenous 5-HT1B receptor (not detectable using radioligand binding) suppress forskolin-stimulated cyclic AMP accumulation and stimulate increases in [Ca2+]i in Chinese hamster ovary cells (CHO).
Gene_expression (expressed) of adenosine A1 receptor in ovary associated with adenocard
3) Confidence 0.66 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652344 Disease Relevance 0 Pain Relevance 0.09
Mundell and Kelly had shown in functional assays that the mouse neuroblastoma x rat glioma hybrid cell line NG108-15 developed by Hamprecht [34], which is frequently used as a model for neuronal cells, expressed two different adenosine receptor subtypes, A2A and A2B [20].
Gene_expression (expressed) of adenosine receptor in neuronal associated with neuroblastoma, adenocard and glioma
4) Confidence 0.20 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0.20 Pain Relevance 0.53
It has also only been investigated at human adenosine receptor subtypes.
Spec (investigated) Gene_expression (subtypes) of adenosine receptor associated with adenocard
5) Confidence 0.15 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096648 Disease Relevance 0 Pain Relevance 0.66
These findings indicate that inflammatory cytokines modulate adenosine receptor expression and function on HMVECs and suggest that the interaction between proinflammatory cytokines and adenosine receptors may affect therapeutic responses to anti-inflammatory drugs that act via adenosine-dependent mechanisms.
Gene_expression (expression) of adenosine receptor associated with adenocard, inflammation, cinod and cytokine
6) Confidence 0.13 Published 2003 Journal J. Immunol. Section Abstract Doc Link 14530318 Disease Relevance 0.19 Pain Relevance 0.73
The location of the residues discussed here is shown in a receptor homology model of the adenosine receptor based on the recently reported crystal structure of the ?
Gene_expression (based) of adenosine receptor associated with adenocard
7) Confidence 0.12 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721769 Disease Relevance 0 Pain Relevance 0.16
The adenosine receptor antagonist, theophylline (100 microM), the dopamine receptors antagonist, haloperidol (10 microM), the cyclooxygenase inhibitor, indomethacin (10 microM) and the phospholipase A(2) inhibitor, quinacrine (10 microM) had no effect on morphine-induced respiratory depression.
Gene_expression (antagonist) of adenosine receptor in respiratory associated with adenocard, depression, dopamine receptor, antagonist, respiratory failure and morphine
8) Confidence 0.02 Published 2000 Journal Brain Res. Section Abstract Doc Link 11082503 Disease Relevance 0.25 Pain Relevance 0.89
However, little is known about the precise role of the opioid receptor subtypes implicated in the modulation of adenosine tissue concentration and in adenosine receptor expression and function.
Gene_expression (expression) of adenosine receptor associated with adenocard and opioid receptor
9) Confidence 0.01 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10854833 Disease Relevance 0.10 Pain Relevance 0.89
Pharmacological and molecular approaches have shown that neutrophils, monocytes and macrophages express all four adenosine receptor subtypes.
Gene_expression (express) of adenosine receptor in macrophages associated with adenocard
10) Confidence 0.01 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 0.59 Pain Relevance 0.78
Pharmacological and molecular approaches have shown that neutrophils, monocytes and macrophages express all four adenosine receptor subtypes.
Gene_expression (express) of adenosine receptor in monocytes associated with adenocard
11) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 0.59 Pain Relevance 0.78
Pharmacological and molecular approaches have shown that neutrophils, monocytes and macrophages express all four adenosine receptor subtypes.
Gene_expression (express) of adenosine receptor in neutrophils associated with adenocard
12) Confidence 0.00 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 0.59 Pain Relevance 0.78

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