INT76256

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Context Info
Confidence 0.20
First Reported 1998
Last Reported 1998
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc6a3, Sigmar1) transport (Sigmar1) nuclear envelope (Sigmar1)
aging (Slc6a3) endoplasmic reticulum (Sigmar1) transmembrane transport (Slc6a3)
Anatomy Link Frequency
caudate putamen 1
Slc6a3 (Rattus norvegicus)
Sigmar1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 16 100.00 Very High Very High Very High
fortral 12 84.88 Quite High
antagonist 6 75.00 Quite High
agonist 4 75.00 Quite High
Analgesic 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some sigma receptor ligands have been shown to bind with low affinity to the dopamine transporter and to inhibit [3H]dopamine uptake.
dopamine transporter Binding (bind) of sigma receptor associated with dopamine
1) Confidence 0.20 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652359 Disease Relevance 0 Pain Relevance 0.49
To further examine the nature of the interaction between sigma receptor ligands and the dopamine transporter, the effects of sigma receptor ligands on amphetamine-stimulated [3H]dopamine release were examined in slices prepared from rat caudate putamen.
dopamine transporter Spec (examine) Binding (interaction) of sigma receptor in caudate putamen associated with dopamine
2) Confidence 0.15 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9652359 Disease Relevance 0 Pain Relevance 0.67

General Comments

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