INT7627

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Context Info
Confidence 0.50
First Reported 1983
Last Reported 2010
Negated 6
Speculated 3
Reported most in Abstract
Documents 162
Total Number 165
Disease Relevance 41.20
Pain Relevance 106.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 22
spike 12
neurons 12
amygdala 10
lateral 8
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 5349 100.00 Very High Very High Very High
nMDA receptor 1751 100.00 Very High Very High Very High
depression 1119 100.00 Very High Very High Very High
antagonist 567 100.00 Very High Very High Very High
substance P 64 100.00 Very High Very High Very High
opioid receptor 48 100.00 Very High Very High Very High
narcan 24 100.00 Very High Very High Very High
central sensitization 17 100.00 Very High Very High Very High
fluoxetine 40 99.98 Very High Very High Very High
cocaine 39 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 1177 100.00 Very High Very High Very High
Li-fraumeni Syndrome 240 100.00 Very High Very High Very High
Stress 810 99.98 Very High Very High Very High
Anaerobic Bacterial Infections 29 99.98 Very High Very High Very High
Shock 75 99.96 Very High Very High Very High
Opiate Addiction 20 99.80 Very High Very High Very High
Targeted Disruption 509 99.64 Very High Very High Very High
Pain 894 99.60 Very High Very High Very High
INFLAMMATION 159 99.40 Very High Very High Very High
Anxiety Disorder 672 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Low-dose Xe in saline 0.9% blocked the induction of LTP.
Negative_regulation (blocked) of Positive_regulation (induction) of LTP
1) Confidence 0.50 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17179253 Disease Relevance 0 Pain Relevance 0
High-dose Xe equilibrated in MC(R) 20% showed no additional effect when compared with the solvent, which blocked the induction of LTP.
Negative_regulation (blocked) of Positive_regulation (induction) of LTP
2) Confidence 0.50 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17179253 Disease Relevance 0 Pain Relevance 0
The induction of LTP was also blocked by 50 ?
Negative_regulation (blocked) of Positive_regulation (induction) of LTP associated with long-term potentiation
3) Confidence 0.50 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.57
CONCLUSION: Kappa opioid receptor activation decreases synaptic transmission and inhibits the induction of LTP in the BLA of the mouse.
Negative_regulation (inhibits) of Positive_regulation (induction) of LTP in BLA
4) Confidence 0.48 Published 2009 Journal Eur J Pain Section Body Doc Link 18439862 Disease Relevance 0 Pain Relevance 0
We also showed that cingulate LTP induced by two other different protocols was also blocked by PD98059.
Negative_regulation (blocked) of Positive_regulation (induced) of LTP associated with long-term potentiation
5) Confidence 0.43 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2245920 Disease Relevance 0.07 Pain Relevance 0.70
Considering that the synaptic potentiation at 0-5 min after LTP induction was not inhibited by protein synthesis inhibitors, protein synthesis-dependent synaptic potentiation begins at 15 min after LTP introduction in ACC neurons.
Negative_regulation (inhibited) of Positive_regulation (induction) of LTP in ACC neurons associated with long-term potentiation and anterior cingulate cortex
6) Confidence 0.43 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0 Pain Relevance 0.55
In a recent study using gene knockout of KA receptor subtype 6 (KA GluR6) mice, the pairing induced LTP was reduced or blocked in the ACC and amygdala, suggesting that KA receptor may contribute to synaptic potentiation [23].


Negative_regulation (reduced) of Positive_regulation (induced) of LTP in amygdala associated with targeted disruption, long-term potentiation, amygdala and anterior cingulate cortex
7) Confidence 0.38 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.10 Pain Relevance 0.90
In the ACC, bath application of a NMDA receptor antagonist AP-5 completely abolished the induction of LTP induced by different induction protocols in the pyramidal cells [16], indicting that the induction of ACC LTP is completely dependent of postsynaptic activation of NMDA receptors.


Negative_regulation (abolished) of Positive_regulation (induction) of LTP in pyramidal cells associated with nmda receptor antagonist, nmda receptor, pyramidal cell, long-term potentiation and anterior cingulate cortex
8) Confidence 0.38 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0 Pain Relevance 1.22
Indeed, in the ACC synapses, bath application of selective NMDA receptorNR2B antagonists significantly reduced but not blocked the induction of LTP by the pairing protocol [16].
Neg (not) Negative_regulation (reduced) of Positive_regulation (induction) of LTP in synapses associated with antagonist, long-term potentiation and anterior cingulate cortex
9) Confidence 0.38 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.06 Pain Relevance 0.83
Iontophoresis LTP was Ca2+ dependent, was blocked by MK-801, and occluded tetanus-induced LTP.
Negative_regulation (blocked) of Positive_regulation (dependent) of LTP associated with anaerobic bacterial infections and long-term potentiation
10) Confidence 0.37 Published 1993 Journal Neuron Section Abstract Doc Link 8098611 Disease Relevance 0.10 Pain Relevance 0.66
When 5-D-aminophosphonovalerate was used to block the induction of LTP, no increase was observed in either case.
Negative_regulation (block) of Positive_regulation (induction) of LTP associated with long-term potentiation
11) Confidence 0.37 Published 1988 Journal Brain Res. Section Abstract Doc Link 2905202 Disease Relevance 0 Pain Relevance 0.38
Bath-perfused morphine augmented the baseline population spike (PS) amplitude in rats treated with saline, whereas it attenuated the LTP induced by chronic morphine infusion.
Negative_regulation (attenuated) of Positive_regulation (induced) of LTP in spike associated with long-term potentiation and morphine
12) Confidence 0.37 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11701207 Disease Relevance 0 Pain Relevance 1.43
LTP induction was significantly attenuated after acute morphine infusion (1 h) in LPP-granule cell synapses of the dentate gyrus.
Negative_regulation (attenuated) of Positive_regulation (induction) of LTP in synapses associated with long-term potentiation and morphine
13) Confidence 0.37 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11701207 Disease Relevance 0 Pain Relevance 1.36
Thus, induction of LTP is suppressed by tonically active supraspinal descending systems.
Negative_regulation (suppressed) of Positive_regulation (induction) of LTP
14) Confidence 0.37 Published 1998 Journal Eur. J. Neurosci. Section Abstract Doc Link 9749775 Disease Relevance 0.16 Pain Relevance 0.43
Fluoxetine and fenfluramine, agents that raise hippocampal extracellular 5-HT concentration, blocked the induction of LTP in nonstressed animals, thus mimicking the effect of stress.
Negative_regulation (blocked) of Positive_regulation (induction) of LTP associated with stress, long-term potentiation and fluoxetine
15) Confidence 0.37 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978839 Disease Relevance 0.43 Pain Relevance 0.47
Remarkably, (+/-) administration of tianeptine after the stress rapidly overcame the block of LTP induction without affecting baseline excitatory transmission.
Negative_regulation (block) of Positive_regulation (induction) of LTP associated with stress and long-term potentiation
16) Confidence 0.37 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11978839 Disease Relevance 0.42 Pain Relevance 0.58
We found that electrical stimulation of the shell enhances the magnitude of LTP while the stimulation of the core completely prevents LTP induction.
Negative_regulation (prevents) of Positive_regulation (induction) of LTP in shell associated with long-term potentiation
17) Confidence 0.37 Published 2008 Journal Neuroscience Section Abstract Doc Link 18160226 Disease Relevance 0 Pain Relevance 0.52
The present results that stress enables LTD but impairs LTP induction at these three ages strengthen a view that stress experience-dependent LTD (SLTD) may underlie stress form of aberrant memories.
Negative_regulation (impairs) of Positive_regulation (induction) of LTP associated with stress, depression and long-term potentiation
18) Confidence 0.37 Published 2004 Journal Brain Res. Section Abstract Doc Link 15044077 Disease Relevance 1.39 Pain Relevance 0.48
Furthermore, acute elevated platform (EP) stress enabled reliable LTD significantly and completely blocked LTP induction at these ages.
Negative_regulation (blocked) of Positive_regulation (induction) of LTP associated with stress, depression and long-term potentiation
19) Confidence 0.37 Published 2004 Journal Brain Res. Section Abstract Doc Link 15044077 Disease Relevance 1.14 Pain Relevance 0.49
These findings suggest that the mechanisms of LTP induction are preferentially impaired by Pb exposure.
Negative_regulation (impaired) of Positive_regulation (induction) of LTP associated with long-term potentiation
20) Confidence 0.37 Published 1996 Journal Brain Res. Section Abstract Doc Link 8930316 Disease Relevance 0.11 Pain Relevance 0.42

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