INT7628

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Context Info
Confidence 0.77
First Reported 1985
Last Reported 2011
Negated 9
Speculated 3
Reported most in Body
Documents 273
Total Number 282
Disease Relevance 70.21
Pain Relevance 147.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
synapses 16
hippocampus 12
neurons 8
dentate gyrus 6
brain 5
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 10658 100.00 Very High Very High Very High
depression 2890 100.00 Very High Very High Very High
nMDA receptor 2040 100.00 Very High Very High Very High
amygdala 1962 100.00 Very High Very High Very High
Hippocampus 1910 100.00 Very High Very High Very High
Anterior cingulate cortex 1765 100.00 Very High Very High Very High
Pyramidal cell 864 100.00 Very High Very High Very High
c fibre 640 100.00 Very High Very High Very High
qutenza 611 100.00 Very High Very High Very High
spinal dorsal horn 551 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 2929 100.00 Very High Very High Very High
Stress 867 100.00 Very High Very High Very High
Aids-related Complex 565 99.96 Very High Very High Very High
Injury 267 99.92 Very High Very High Very High
Pain 1414 99.84 Very High Very High Very High
Nociception 667 99.84 Very High Very High Very High
Anxiety Disorder 1288 99.76 Very High Very High Very High
Targeted Disruption 1874 99.50 Very High Very High Very High
Convulsion 145 99.50 Very High Very High Very High
Anaerobic Bacterial Infections 153 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significance of this hypothesis is underscored by results suggesting that LTP expression may involve activity-dependent presynaptic changes.
Gene_expression (expression) of LTP associated with long-term potentiation
1) Confidence 0.77 Published 1993 Journal Neuron Section Abstract Doc Link 8098611 Disease Relevance 0.08 Pain Relevance 0.60
The HFS paradigm has been chosen since theta burst stimulation did not produce consistent and reliable induction of LA-LTP.


Neg (not) Gene_expression (produce) of LTP associated with long-term potentiation and amygdala
2) Confidence 0.69 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 0.35
Recent findings suggest that while ACC LTP in brain slice preparations is postsynaptically induced and expressed, injury triggered synaptic potentiation in the ACC contains both presynaptic enhancement of glutamate release and postsynaptic potentiation of AMPA receptor-mediated responses.
Gene_expression (expressed) of LTP in ACC associated with glutamate, injury, long-term potentiation and anterior cingulate cortex
3) Confidence 0.61 Published 2009 Journal Mol. Neurobiol. Section Abstract Doc Link 19821080 Disease Relevance 0.44 Pain Relevance 0.97
While the induction of LTP in general requires activation of postsynaptic glutamate receptors, the expression of LTP can be mediated by postsynaptic mechanisms and/or presynaptic enhancement of glutamate release.
Gene_expression (expression) of LTP associated with glutamate, glutamate receptor and long-term potentiation
4) Confidence 0.61 Published 2009 Journal Mol. Neurobiol. Section Abstract Doc Link 19821080 Disease Relevance 0.41 Pain Relevance 0.85
Capsaicin dose-dependently reduces LA-LTP in horizontal slices
Gene_expression (reduces) of LTP associated with qutenza, long-term potentiation and amygdala
5) Confidence 0.60 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.08
However, the suppressive effect of capsaicin on LA-LTP was also present in coronal slices derived from juvenile mice (control: 120.5±3.2% [n?
Gene_expression (effect) of LTP in juvenile associated with qutenza, long-term potentiation and amygdala
6) Confidence 0.60 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 0.95
Because none of the changes in sensory parameters was unique for the site of conditioning stimulation, these data suggest that heterosynaptic interactions are the predominant mechanism of LTP in nociceptive pathways.
Gene_expression (mechanism) of LTP associated with nociception and long-term potentiation
7) Confidence 0.58 Published 2008 Journal Pain Section Abstract Doc Link 18602755 Disease Relevance 0.99 Pain Relevance 1.16
This phenomenon is consistent with a previous report, in which PD98059 had no effect on the expression of LTP in the hippocampus [23].
Gene_expression (expression) of LTP in hippocampus associated with hippocampus and long-term potentiation
8) Confidence 0.57 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.92
In our previous study, we have shown that the expression of LTP in the ACC depends on a postsynaptic mechanism [3].
Gene_expression (expression) of LTP associated with long-term potentiation and anterior cingulate cortex
9) Confidence 0.57 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.53
It has been reported that an alteration in AMPA receptor channel kinetics could underlie the expression of LTP [26].
Gene_expression (expression) of LTP associated with long-term potentiation
10) Confidence 0.57 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.39
Several mechanisms could explain the role of CaMKIV in early-phase protein synthesis dependent LTP.
Gene_expression (synthesis) of LTP associated with long-term potentiation
11) Confidence 0.57 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.41 Pain Relevance 0.51
The cause of differences in LTP expression across SR levels may stem from a greater propensity of proximal dendrites to generate dendritic spikes.
Gene_expression (expression) of LTP in dendrites associated with long-term potentiation
12) Confidence 0.54 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.06 Pain Relevance 0.47
Therefore, in all cases we expressed LTP data in a normalised form, dividing the fEPSP amplitude in the tetanised pathway by the amplitude of the control fEPSP for each time point.
Gene_expression (expressed) of LTP associated with long-term potentiation
13) Confidence 0.54 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.34 Pain Relevance 0.18
The mechanism of expression of classical mossy fiber LTP has been shown to be presynaptically located and based on an increase in the probability of transmitter release (Pr) [11].
Gene_expression (expression) of LTP in mossy fiber associated with long-term potentiation
14) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848597 Disease Relevance 0 Pain Relevance 0.45
Under these conditions, HFS was unable to evoke LA-LTP.
Neg (unable) Gene_expression (unable) of LTP associated with long-term potentiation and amygdala
15) Confidence 0.53 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.16 Pain Relevance 1.03
GABA transmission is not involved in mediating capsaicin-induced effects on LA-LTP
Gene_expression (transmission) of LTP associated with gaba, qutenza, long-term potentiation and amygdala
16) Confidence 0.53 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.06 Pain Relevance 1.86
To examine whether capsaicin-induced suppression of LTP is mediated by TRPV1 receptors, we analyzed the effects of capsaicin in the presence of capsazepine (CZ), a TRPV1 receptor antagonist.
Gene_expression (suppression) of LTP associated with qutenza, antagonist and long-term potentiation
17) Confidence 0.53 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.51
The AM251-induced LTP suppression in the hippocampus was interpreted by the action of AM251 over GABAergic interneurons that (indirectly) modulate the glutamatergic, LTP-bearing pyramidal cells.
Gene_expression (suppression) of LTP in pyramidal cells associated with pyramidal cell, gabaergic, hippocampus and long-term potentiation
18) Confidence 0.53 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.19
DBA/2, on the other hand, has a normal induction of LTP but their ability to maintain the LTP is impaired.
Gene_expression (maintain) of LTP
19) Confidence 0.52 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2409357 Disease Relevance 0.36 Pain Relevance 0.31
This work demonstrated that LTP probe ion source combined with MS is a high-throughput method for screening of pharmaceuticals and potentially applied to on-line quality control in pharmaceutical industry.
Gene_expression (source) of LTP in LTP
20) Confidence 0.52 Published 2009 Journal Anal Bioanal Chem Section Abstract Doc Link 19641907 Disease Relevance 0.17 Pain Relevance 0.12

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