INT7630

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 0.73
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (SLC2A1) plasma membrane (SLC2A1) intracellular (SLC2A1)
carbohydrate metabolic process (SLC2A1) transmembrane transport (SLC2A1) cytoplasm (SLC2A1)
Anatomy Link Frequency
blood 1
brain 1
interneurons 1
SLC2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 165 97.92 Very High Very High Very High
antagonist 5 95.92 Very High Very High Very High
Pyramidal cell 4 86.96 High High
tetrodotoxin 1 73.04 Quite High
cva 39 24.28 Low Low
ischemia 27 5.00 Very Low Very Low Very Low
tissue acidosis 6 5.00 Very Low Very Low Very Low
analgesia 6 5.00 Very Low Very Low Very Low
Versed 6 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Injury 60 99.00 Very High Very High Very High
Hypoglycemia 18 97.88 Very High Very High Very High
Cv General 3 Under Development 39 24.28 Low Low
Cv Unclassified Under Development 24 5.00 Very Low Very Low Very Low
Injury 15 5.00 Very Low Very Low Very Low
Hyperglycemia 12 5.00 Very Low Very Low Very Low
Contusions 9 5.00 Very Low Very Low Very Low
Sleep Disorders 6 5.00 Very Low Very Low Very Low
Critical Illness 6 5.00 Very Low Very Low Very Low
Acidosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This pattern suggests functional adaptive processes possibly by increased GLUT transporter activity at low arterial blood glucose levels and decreased GLUT transporter activity at higher arterial blood glucose levels.
Negative_regulation (decreased) of GLUT in blood
1) Confidence 0.45 Published 2010 Journal Crit Care Section Body Doc Link PMC2875528 Disease Relevance 0.20 Pain Relevance 0
This could reflect a saturation effect as suggested by experimental data showing that the bi-directional flux is influenced by the glucose concentration gradient, which reduces GLUT activity at increased brain glucose levels [37].
Negative_regulation (reduces) of GLUT in brain
2) Confidence 0.45 Published 2010 Journal Crit Care Section Body Doc Link PMC2875528 Disease Relevance 0.17 Pain Relevance 0
Repetitive electrical stimulation depressed early and late IPSPs as well as glut-IPSPs, suggesting that interneurons activated with glutamate were also stimulated electrically.
Negative_regulation (depressed) of glut in interneurons associated with glutamate
3) Confidence 0.41 Published 1992 Journal Synapse Section Abstract Doc Link 1353275 Disease Relevance 0 Pain Relevance 0.56
Following experimental TBI, significantly increased GLUT3 and significantly decreased GLUT1 [38] suggests a mechanism of autoprotection against hypoglycemia due to increased expression of high affinity GLUT3 transporters (Km 2.8 mM).
Negative_regulation (decreased) of GLUT1 associated with hypoglycemia and brain injury
4) Confidence 0.33 Published 2010 Journal Crit Care Section Body Doc Link PMC2875528 Disease Relevance 0.35 Pain Relevance 0
Nucleotides decrease Glut1 transport activity, thus generating an inverse relationship between transporter activity and cellular energy levels.
Negative_regulation (decrease) of Glut1
5) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669215 Disease Relevance 0 Pain Relevance 0
Nucleotide binding is also a feature of the human glucose transporter (Glut1), another member of the MF transporter family [31].
Negative_regulation (feature) of Glut1
6) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669215 Disease Relevance 0 Pain Relevance 0

General Comments

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