INT76303

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Hspb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 99.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 3 98.48 Very High Very High Very High
Toxicity 1 80.40 Quite High
Shock 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even though APAP hepatotoxicity was blocked by NAC administered 0 or 1 hr after the APAP dose, NAC did not inhibit the induction of hsp25 or hsp70i, indicating that APAP arylation of protein may play a key role in triggering hsp induction.
Negative_regulation (inhibit) of Positive_regulation (induction) of hsp25 associated with paracetamol and hepatotoxicity
1) Confidence 0.42 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9655897 Disease Relevance 0.49 Pain Relevance 1.17

General Comments

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