INT76315

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Context Info
Confidence 0.41
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 18
Disease Relevance 6.79
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Myog) nucleus (Myog) DNA binding (Myog)
Anatomy Link Frequency
muscle 7
Satellite cell 2
P19 1
smooth muscle 1
chest 1
Myog (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 2 95.96 Very High Very High Very High
ischemia 1 94.60 High High
withdrawal 7 90.52 High High
Inflammation 50 81.20 Quite High
cytokine 43 80.96 Quite High
cva 1 77.44 Quite High
tolerance 7 58.44 Quite High
dexamethasone 7 55.72 Quite High
fibrosis 36 53.28 Quite High
Pain 5 30.60 Quite Low
Disease Link Frequency Relevance Heat
Cancer 222 99.90 Very High Very High Very High
Frailty 191 99.20 Very High Very High Very High
Myocardial Infarction 12 99.16 Very High Very High Very High
Leiomyosarcoma 3 98.20 Very High Very High Very High
Apoptosis 40 97.60 Very High Very High Very High
Injury 86 97.44 Very High Very High Very High
Angina 2 95.96 Very High Very High Very High
Muscular Dystrophy 7 95.24 Very High Very High Very High
Coronary Artery Disease 1 95.04 Very High Very High Very High
Fibrosarcoma 2 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next investigated the effect of As2O3 on myogenin expression during myogenic differentiation using immunocytochemistry (Figure 4) and Western blotting (Figure 5A).
Gene_expression (expression) of myogenin
1) Confidence 0.41 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0 Pain Relevance 0
In the present study, using morphologic examination, we also found that As2O3 (0.5 and 5 ppm) effectively suppressed myogenin expression and retarded muscle regeneration in mouse soleus muscles after injury by glycerol.
Gene_expression (expression) of myogenin in muscles associated with injury
2) Confidence 0.41 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.46 Pain Relevance 0
We observed an increase of myogenin expression and Akt phosphorylation in the soleus muscles on day 3 after glycerol injection, but it was suppressed in As2O3-treated mice compared with control mice (Figure 8).
Gene_expression (expression) of myogenin in muscles
3) Confidence 0.41 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.24 Pain Relevance 0.04
M) significantly decreased myogenin expression during myogenic differentiation in a dose-dependent manner (Figures 4, 5A).
Gene_expression (expression) of myogenin
4) Confidence 0.41 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0 Pain Relevance 0
Myogenesis is largely regulated by the myogenic basic helix-loop-helix family of transcription factors (MyoD, myogenin, myf5, and MRF4) and myocyte enhancer factor 2, which regulate the expression of many muscle-specific genes, such as the myosin heavy chain (MHC) and creatine kinase (Lassar et al. 1994; Olson et al. 1995).
Gene_expression (family) of myogenin in muscle
5) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.26 Pain Relevance 0.07
M) dose-dependently inhibited in vitro skeletal muscle differentiation as assessed by myogenin and MHC expression, creatine kinase activity, and formation of multinucleated myotubes without apparent effects on cell viability.
Gene_expression (expression) of myogenin in myotubes
6) Confidence 0.36 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.57 Pain Relevance 0.03
The present study suggests an alternative mechanism based on ERK activation: when the C26 hosts are treated with PD, and ERK is thus inhibited, Pax7 and myogenin expression is restored to control values.
Gene_expression (expression) of myogenin
7) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.40 Pain Relevance 0
While MyoD remains generally detectable, although at variable levels, high and low expression of Pax7 and myogenin, respectively, characterizes proliferating satellite cells, while the opposite pattern defines differentiating cells [43].
Gene_expression (expression) of myogenin in satellite cells
8) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.35 Pain Relevance 0.07
Regeneration of glycerol-injured soleus muscles, myogenin expression, and Akt phosphorylation were suppressed in muscles isolated from As2O3-treated mice compared with untreated mice.


Gene_expression (expression) of myogenin in muscles
9) Confidence 0.32 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC2920914 Disease Relevance 0.22 Pain Relevance 0
In C26 hosts, muscle wasting is also associated with increased Pax7 expression and reduced myogenin levels.
Gene_expression (expression) of myogenin in muscle associated with frailty
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965098 Disease Relevance 0.80 Pain Relevance 0.04
Satellite cell phenotype is defined by the differential expression of specific factors, among which Pax7, MyoD and myogenin.
Gene_expression (expression) of myogenin in Satellite cell
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.35 Pain Relevance 0.07
It has been hypothesized that creatine increases the expression of myogenic transcription factors such as myogenin and myogenic regulatory factor-4, which increases muscle mass and strength.119 Creatine supplementation increases muscle phosphocreatine levels leading to a decrease in muscle relaxation time.120,121 This may increase the ability to perform high-intensity exercise as well as enhance muscle protein synthesis, lean skeletal muscle mass, and strength during periods of high intensity training.
Gene_expression (expression) of myogenin in muscle
12) Confidence 0.21 Published 2010 Journal Clin Interv Aging Section Body Doc Link PMC2938029 Disease Relevance 0.28 Pain Relevance 0
The differences in the expression of myogenic regulatory factors, MyoD and myogenin, as well as GATA4 and MEF-2, in response of P19 cells to OT and OT-GKR stimulation, can influence the developmental decisions of stem cells differentiating into the skeletal or cardiac muscle lineage.
Gene_expression (expression) of myogenin in P19
13) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964328 Disease Relevance 0.14 Pain Relevance 0
CONCLUSION: Comparing the changes in serum total CK, levels of CK-MB, Myo and carnitine, the sensitivity and specificity were significantly higher for serum free L-carnitine.
Gene_expression (levels) of Myo
14) Confidence 0.12 Published 2009 Journal Clin. Biochem. Section Body Doc Link 18930039 Disease Relevance 0.06 Pain Relevance 0
Serum MYO levels in 53 patients with acute myocardial infarction (AMI), 100 healthy individuals, seven patients with chest pain but without myocardial ischemia and in 39 patients with renal insufficiency were measured simultaneously by DIGFA and enzyme-linked immunosorbent assay (ELISA).
Gene_expression (levels) of MYO in chest associated with angina, coronary artery disease, ischemia, renal insufficiency and myocardial infarction
15) Confidence 0.10 Published 1998 Journal Clin. Chim. Acta Section Abstract Doc Link 9657343 Disease Relevance 0.46 Pain Relevance 0.14
The beneficial effects of exercise may, at least partly, be brought about by an increase in the expression of myogenin (Siu, Donley et al 2004), a reduction of the occurrence of apoptosis (Siu, Bryner et al 2004), and suppression of the muscle specific ubiquitin ligase atrogin (Leger et al 2006).
Gene_expression (expression) of myogenin in muscle associated with apoptosis
16) Confidence 0.08 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 0.47 Pain Relevance 0.10
Differential diagnosis of a leiomyosarcoma of the bone had to be taken into account, but this was less likely because the tumor was negative for desmin and myogenin.
Neg (negative) Gene_expression (negative) of myogenin associated with leiomyosarcoma and cancer
17) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2889898 Disease Relevance 1.04 Pain Relevance 0
The neoplastic cells were positive for vimentin, alpha smooth muscle actin, osteonectin, CD99, and S100 in the chondroblastic portion, but negative for cytokeratin, epithelial membrane antigen, desmin, myogenin, CD34, and c-kit.
Neg (negative) Gene_expression (negative) of myogenin in smooth muscle
18) Confidence 0.02 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1878495 Disease Relevance 0.70 Pain Relevance 0.04

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