INT76342

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Context Info
Confidence 0.56
First Reported 1998
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.29
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox5) nuclear envelope (Alox5) oxidoreductase activity (Alox5)
nucleus (Alox5) cytoplasm (Alox5)
Anatomy Link Frequency
aorta 4
brain 3
cortex 3
heart 3
plasma 2
Alox5 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 70 99.62 Very High Very High Very High
qutenza 2 99.60 Very High Very High Very High
Hippocampus 63 99.44 Very High Very High Very High
ischemia 15 98.56 Very High Very High Very High
Inflammatory response 1 97.88 Very High Very High Very High
Chronic pancreatitis 1 93.56 High High
bradykinin 2 91.68 High High
Dopamine 1 90.96 High High
Pain 4 90.00 High High
Inflammation 54 88.80 High High
Disease Link Frequency Relevance Heat
Aging 273 100.00 Very High Very High Very High
Brain Hemorrhage 7 98.80 Very High Very High Very High
INFLAMMATION 55 97.48 Very High Very High Very High
Pancreatic Cancer 4 94.88 High High
Urological Neuroanatomy 35 94.40 High High
Pancreatitis 1 93.56 High High
Chronic Renal Failure 10 92.56 High High
Disease 13 90.08 High High
Pain 1 90.00 High High
Depression 14 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although leukotriene synthesis in the CNS and in the heart can occur via a transcellular biosynthetic pathway that is believed not to require 5-LOX expression [12, 13], aging-increased leukotriene synthesis in the hippocampus [14] and aorta [38] appears to be associated with increased 5-LOX expression.
Positive_regulation (increased) of Gene_expression (expression) of 5-LOX in aorta associated with aging, hippocampus and central nervous system
1) Confidence 0.56 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.31 Pain Relevance 0.26
In the CNS of rats and mice, 5-LOX expression increases during aging [14, 17] and in brain ischemia [18, 19].
Positive_regulation (increases) of Gene_expression (expression) of 5-LOX in brain associated with brain hemorrhage, aging, ischemia and central nervous system
2) Confidence 0.56 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.90 Pain Relevance 0.45
Overexpression of 5-LOX in NIH3T3 cells resulted in greater sensitivity of these cells to the growth inhibitory effects of the 5-LOX inhibitor Rev5901.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of 5-LOX
3) Confidence 0.46 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16024599 Disease Relevance 0.50 Pain Relevance 0.09
The authors propose that NNK-derived intermediates induce the expression of COX-2 and lipoxygenase involved in NNK activation.
Positive_regulation (induce) of Gene_expression (expression) of lipoxygenase
4) Confidence 0.41 Published 1998 Journal Exp. Lung Res. Section Abstract Doc Link 9659586 Disease Relevance 0.30 Pain Relevance 0.19
This information appears necessary for a full understanding of the biological implications of aging-altered expression of 5-LOX in the brain and heart.
Spec (appears) Positive_regulation (necessary) of Gene_expression (expression) of 5-LOX in heart associated with aging
5) Confidence 0.41 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.45 Pain Relevance 0.25
Although leukotriene synthesis in the CNS and in the heart can occur via a transcellular biosynthetic pathway that is believed not to require 5-LOX expression [12, 13], aging-increased leukotriene synthesis in the hippocampus [14] and aorta [38] appears to be associated with increased 5-LOX expression.
Neg (not) Positive_regulation (require) of Gene_expression (expression) of 5-LOX in aorta associated with aging, hippocampus and central nervous system
6) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.23 Pain Relevance 0.24
These differences do not appear to be species-related (e.g., rat versus mouse) because others found that aging increases 5-LOX expression in the mouse hippocampus but not in the cerebellum and cortex [14].
Positive_regulation (increases) of Gene_expression (expression) of 5-LOX in cortex associated with aging and hippocampus
7) Confidence 0.38 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.76 Pain Relevance 0.17
Inhibition of sEH and 5/6-Nx results in increased plasma level of lipoxygenase products
Positive_regulation (increased) of Gene_expression (products) of lipoxygenase in plasma
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2915917 Disease Relevance 0.24 Pain Relevance 0.08
This information appears necessary for a full understanding of the biological implications of aging-altered expression of 5-LOX in the brain and heart.
Spec (appears) Positive_regulation (necessary) of in brain Gene_expression (expression) of 5-LOX in heart associated with aging
9) Confidence 0.14 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.45 Pain Relevance 0.25
These differences do not appear to be species-related (e.g., rat versus mouse) because others found that aging increases 5-LOX expression in the mouse hippocampus but not in the cerebellum and cortex [14].
Positive_regulation (increases) of in cerebellum Gene_expression (expression) of 5-LOX in cortex associated with aging and hippocampus
10) Confidence 0.13 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.76 Pain Relevance 0.17
Because lipoxygenase products can activate TRPV1 in sensory neurons, upstream signals to lipoxygenase/TRPV1 pathway have been questioned.
Positive_regulation (activate) of Gene_expression (products) of lipoxygenase in sensory neurons
11) Confidence 0.07 Published 2005 Journal Curr. Pharm. Des. Section Abstract Doc Link 16101449 Disease Relevance 0.38 Pain Relevance 0.70

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