INT76370

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Context Info
Confidence 0.32
First Reported 1998
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
microglial cells 2
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2 74.48 Quite High
Pain 3 25.00 Low Low
COX2 2 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 98.24 Very High Very High Very High
Pain 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the peritoneal cells, the mRNA expression for the constitutive cyclooxygenase-1 (COX-1) was unchanged by PQ administration.
Neg (unchanged) Regulation (unchanged) of Transcription (expression) of cyclooxygenase-1
1) Confidence 0.32 Published 1998 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 9661217 Disease Relevance 0.07 Pain Relevance 0.04
METHODS: The effects of amygdalin extracted from Armeniacae semen on the LPS-stimulated mRNA expressions of cyclooxygenase (COX)-1, COX-2 and inducible nitric oxide synthase (iNOS) in the mouse BV2 microglial cells were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction (RT-PCR).
Spec (investigated) Regulation (effects) of Transcription (expressions) of cyclooxygenase in microglial cells
2) Confidence 0.05 Published 2007 Journal Neurol. Res. Section Body Doc Link 17359643 Disease Relevance 0.10 Pain Relevance 0

General Comments

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