INT76373

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Context Info
Confidence 0.38
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.84
Pain Relevance 3.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
cortex 6
arcuate nucleus 2
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 7 98.08 Very High Very High Very High
Pyramidal cell 3 97.60 Very High Very High Very High
Hippocampus 8 97.56 Very High Very High Very High
depression 4 97.44 Very High Very High Very High
amygdala 4 96.92 Very High Very High Very High
Neuropeptide 26 91.92 High High
Cholecystokinin 6 90.16 High High
Enkephalin 10 87.92 High High
Nucleus accumbens 2 87.04 High High
Somatostatin 8 83.84 Quite High
Disease Link Frequency Relevance Heat
Depression 4 97.44 Very High Very High Very High
Convulsion 8 83.44 Quite High
Aggression 3 78.32 Quite High
Poisoning 6 75.00 Quite High
Epilepsy 3 68.16 Quite High
Sprains And Strains 4 52.64 Quite High
Depressive Disorder 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization histochemistry was used to measure mRNA expression levels of NPY and NPY receptors, Y1 and Y2, in the FSL as compared to the control Flinder resistant Line rats (FRL).
Positive_regulation (levels) of Gene_expression (expression) of Y1
1) Confidence 0.38 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9729278 Disease Relevance 0.32 Pain Relevance 0.52
Conversely, as expected, arcuate nucleus NPY mRNA expression was markedly upregulated by negative energy balance, but was unchanged by recent food consumption.
Positive_regulation (upregulated) of Gene_expression (expression) of NPY mRNA in arcuate nucleus
2) Confidence 0.32 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16931647 Disease Relevance 0 Pain Relevance 0.45
These results coincide with the previous findings with the elevated expression of SRIF and NPY mRNA in electrically and pharmacologically kindled models, suggesting the important role of these peptides in the kindling phenomenon.
Positive_regulation (elevated) of Gene_expression (expression) of NPY mRNA
3) Confidence 0.18 Published 2000 Journal Brain Res. Section Abstract Doc Link 10678775 Disease Relevance 0.15 Pain Relevance 0.57
Strong over-expression of NPY mRNA was also observed in hilar interneurons and in CA1 and CA3 pyramidal cells as well as in the cortex at 5 days postdosing.
Positive_regulation (over) of Gene_expression (over) of NPY mRNA in cortex associated with pyramidal cell
4) Confidence 0.12 Published 1998 Journal Synapse Section Abstract Doc Link 9661251 Disease Relevance 0.46 Pain Relevance 0.70
Strong over-expression of NPY mRNA was also observed in hilar interneurons and in CA1 and CA3 pyramidal cells as well as in the cortex at 5 days postdosing.
Positive_regulation (over) of Gene_expression (expression) of NPY mRNA in cortex associated with pyramidal cell
5) Confidence 0.08 Published 1998 Journal Synapse Section Abstract Doc Link 9661251 Disease Relevance 0.46 Pain Relevance 0.70
Strong over-expression of NPY mRNA was also observed in hilar interneurons and in CA1 and CA3 pyramidal cells as well as in the cortex at 5 days postdosing.
Positive_regulation (over) of Gene_expression (-) of NPY mRNA in cortex associated with pyramidal cell
6) Confidence 0.08 Published 1998 Journal Synapse Section Abstract Doc Link 9661251 Disease Relevance 0.46 Pain Relevance 0.70

General Comments

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