INT76374

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Context Info
Confidence 0.35
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 0.40
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Flvcr2) transmembrane transport (Flvcr2)
Flvcr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 26 100.00 Very High Very High Very High
antidepressant 110 99.98 Very High Very High Very High
Duloxetine 76 99.92 Very High Very High Very High
Potency 20 99.04 Very High Very High Very High
opiate 2 97.56 Very High Very High Very High
mu opioid receptor 1 94.04 High High
sNRI 68 87.92 High High
intrathecal 1 83.44 Quite High
backache 1 81.76 Quite High
sSRI 184 79.68 Quite High
Disease Link Frequency Relevance Heat
Confusion 4 94.24 High High
Low Back Pain 1 81.76 Quite High
Depression 74 50.00 Quite Low
Pain 4 50.00 Quite Low
Syndrome 8 28.76 Quite Low
Reprotox - General 2 32 25.52 Quite Low
Overdose 24 5.00 Very Low Very Low Very Low
Toxicity 24 5.00 Very Low Very Low Very Low
Recurrence 24 5.00 Very Low Very Low Very Low
Sleep Disorders 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KEY RESULTS: WAY-318068 is a potent and effective inhibitor of the NET with a K(i) of 8.7 nM in a binding assay, and an IC(50) of 6.8 nM in an assay of transporter function, without significant binding to the dopamine transporter.
Negative_regulation (inhibitor) of transporter Binding (binding) of
1) Confidence 0.35 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20590604 Disease Relevance 0 Pain Relevance 0
KEY RESULTS: WAY-318068 is a potent and effective inhibitor of the NET with a K(i) of 8.7 nM in a binding assay, and an IC(50) of 6.8 nM in an assay of transporter function, without significant binding to the dopamine transporter.
Negative_regulation (inhibitor) of transporter Binding (binding) of
2) Confidence 0.35 Published 2010 Journal Br. J. Pharmacol. Section Body Doc Link 20590604 Disease Relevance 0 Pain Relevance 0
Fentanyl decreases beta-CIT binding to the dopamine transporter.
Negative_regulation (decreases) of transporter Binding (binding) of associated with dopamine
3) Confidence 0.29 Published 1998 Journal Synapse Section Title Doc Link 9661259 Disease Relevance 0.08 Pain Relevance 0.58
The selectivity of an antidepressant is the ratio of the potency values for NE and 5-HT reuptake inhibition (or inhibition of binding to the transporter).
Negative_regulation (inhibition) of transporter Binding (binding) of associated with antidepressant and potency
4) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 0.05 Pain Relevance 0.37
Thus from Table 1 it can be seen that duloxetine is 154 times more potent than milnacipran at blocking the binding of 5-HT to the transporter (ie, 154 times more milnacipran is required to obtain the same effect).
Negative_regulation (blocking) of transporter Binding (binding) of associated with duloxetine
5) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 0.09 Pain Relevance 0.52
To block the binding of NE to its transporter, duloxetine is about 27 times more potent than milnacipran.
Negative_regulation (block) of transporter Binding (binding) of associated with duloxetine
6) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 0.08 Pain Relevance 0.45
Potency reflects the concentration of the antidepressant inhibiting 50% of uptake or binding to the transporter, depending on the technique used.
Negative_regulation (inhibiting) of transporter Binding (binding) of associated with antidepressant and potency
7) Confidence 0.04 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938282 Disease Relevance 0.09 Pain Relevance 0.54

General Comments

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