INT76376

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Context Info
Confidence 0.15
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.22
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cit) vacuole (Cit) kinase activity (Cit)
cytoplasm (Cit)
Anatomy Link Frequency
basal ganglia 4
striatum 2
Cit (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 6 97.52 Very High Very High Very High
Dopamine 18 96.20 Very High Very High Very High
imagery 6 94.04 High High
backache 3 82.84 Quite High
intrathecal 3 81.24 Quite High
mu opioid receptor 3 70.96 Quite High
Disease Link Frequency Relevance Heat
Low Back Pain 3 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly in rats, acute fentanyl treatment decreased [123I]beta-CIT binding to the striatum by 30% as compared to that of with the control rats.
Negative_regulation (decreased) of beta-CIT Binding (binding) of in striatum
1) Confidence 0.15 Published 1998 Journal Synapse Section Abstract Doc Link 9661259 Disease Relevance 0.08 Pain Relevance 0.57
According to the present data, fentanyl decreases [123I]beta-CIT binding in the basal ganglia both in human and rats, suggesting that opiates possibly directly affect DA reuptake.
Negative_regulation (decreases) of beta-CIT Binding (binding) of in basal ganglia associated with dopamine and opiate
2) Confidence 0.15 Published 1998 Journal Synapse Section Abstract Doc Link 9661259 Disease Relevance 0.07 Pain Relevance 0.49
In a female patient, [123I]beta-CIT binding in the basal ganglia was decreased by 37% during fentanyl as compared to the binding after 2-week drug-free period.
Negative_regulation (decreased) of beta-CIT Binding (binding) of in basal ganglia
3) Confidence 0.15 Published 1998 Journal Synapse Section Abstract Doc Link 9661259 Disease Relevance 0.08 Pain Relevance 0.59

General Comments

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