INT76396

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Context Info
Confidence 0.65
First Reported 1998
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.89
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10, Il1b) extracellular region (Il10, Il1b) aging (Il1b)
intracellular (Il10)
Anatomy Link Frequency
paw 1
Il10 (Mus musculus)
Il1b (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 2 100.00 Very High Very High Very High
allodynia 2 100.00 Very High Very High Very High
Neuropathic pain 2 99.12 Very High Very High Very High
Pain 2 94.08 High High
cytokine 2 93.16 High High
IPN 1 92.76 High High
Hyperalgesia 2 91.28 High High
Inflammation 1 89.04 High High
neuralgia 6 25.00 Low Low
nociceptor 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 4 100.00 Very High Very High Very High
Necrosis 3 95.76 Very High Very High Very High
Cancer 3 95.40 Very High Very High Very High
Pain 2 94.08 High High
Inflammatory Pain 1 92.76 High High
INFLAMMATION 1 89.04 High High
Targeted Disruption 2 87.04 High High
Nociception 4 76.32 Quite High
Hyperalgesia 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, exogenous interleukin-10 (IL-10) was shown to impede development of dynorphin-induced allodynia presumably by inhibiting IL-1beta.
interleukin-10 Negative_regulation (inhibiting) of IL-1beta associated with allodynia and dynorphin
1) Confidence 0.65 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12799032 Disease Relevance 0.72 Pain Relevance 0.39
IL-10 downregulated the levels of TNFalpha (from 4974.75 +/- 875.78 to 1008 +/- 350 pg/hind paw), NGF (from 352.9 +/- 46.7 to 33.9 +/- 2.4 pg/hind paw) and IL-1beta (from 2773.88 +/- 423.96 to 1108 +/- 399.56 pg/hind paw).
IL-10 Negative_regulation (downregulated) of IL-1beta in paw
2) Confidence 0.62 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9663559 Disease Relevance 0.45 Pain Relevance 0.30
Recently, exogenous interleukin-10 (IL-10) was shown to impede development of dynorphin-induced allodynia presumably by inhibiting IL-1beta.
IL-10 Negative_regulation (inhibiting) of IL-1beta associated with allodynia and dynorphin
3) Confidence 0.48 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 12799032 Disease Relevance 0.72 Pain Relevance 0.39

General Comments

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