INT76403

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 8.36
Pain Relevance 3.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cnp) plasma membrane (Cnp) intracellular (Cnp)
cytoplasm (Cnp)
Anatomy Link Frequency
oligodendrocytes 3
spinal cords 2
nucleus 2
fascicles 1
arterioles 1
Cnp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 29 99.38 Very High Very High Very High
Spinal cord 137 98.66 Very High Very High Very High
ischemia 156 98.16 Very High Very High Very High
Pain 2 96.20 Very High Very High Very High
bDMF 6 96.08 Very High Very High Very High
nMDA receptor 66 94.20 High High
qutenza 168 87.76 High High
cerebral cortex 2 70.20 Quite High
dorsal root ganglion 33 68.20 Quite High
Glutamate 48 66.40 Quite High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 9 99.96 Very High Very High Very High
Natriuresis 20 99.80 Very High Very High Very High
Targeted Disruption 28 99.60 Very High Very High Very High
Diabetes Mellitus 25 98.44 Very High Very High Very High
Cv Unclassified Under Development 66 98.16 Very High Very High Very High
Apoptosis 31 98.00 Very High Very High Very High
Brain Hemorrhage 86 97.88 Very High Very High Very High
Hypoxia 28 97.00 Very High Very High Very High
Erythema 1 96.72 Very High Very High Very High
Embolism 30 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in CNPase knockout mice indicate that CNPase expressing cells are required to support axonal integrity [35].
Gene_expression (expressing) of CNPase associated with targeted disruption
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 1.05 Pain Relevance 0.09
Epineurial arterioles express CNP, and exogenous CNP causes a concentration-dependent vascular relaxation.
Gene_expression (express) of CNP in arterioles
2) Confidence 0.66 Published 2007 Journal Diabetes Section Abstract Doc Link 17259379 Disease Relevance 0.76 Pain Relevance 0
OPCs were identified by NG2 positive cells, while myelinating oligodendrocytes were detected by cyclic nucleotide phosphodiesterase (CNPase) or myelin basic protein (MBP) immunoreactive cells [20].
Gene_expression (detected) of cyclic nucleotide phosphodiesterase in oligodendrocytes
3) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.41 Pain Relevance 0.05
Indeed, BrdU and CNPase immunoreactive cells were detected in the ischemic boundary region and confocal images revealed co-localization BrdU in the nucleus and CNPase in the cytoplasm of the same cell (Fig. 4O-R).
Gene_expression (nucleus) of CNPase in nucleus
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.37 Pain Relevance 0.04
OPCs were identified by NG2 positive cells, while myelinating oligodendrocytes were detected by cyclic nucleotide phosphodiesterase (CNPase) or myelin basic protein (MBP) immunoreactive cells [20].
Gene_expression (detected) of CNPase in oligodendrocytes
5) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.41 Pain Relevance 0.05
The pGC activity in response to CNP and cGMP production in gastric smooth muscle were measured by using radioimmunoassay (RIA) in normal and diabetic rats.
Gene_expression (production) of CNP in gastric smooth muscle associated with diabetes mellitus
6) Confidence 0.57 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 19267196 Disease Relevance 1.69 Pain Relevance 0.16
Confocal images of the nervous area inside the conduit revealed noteworthy distribution of regenerated myelinated fascicles (MBP, CNPase, ?
Gene_expression (fascicles) of CNPase in fascicles
7) Confidence 0.41 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2358889 Disease Relevance 0.24 Pain Relevance 0
Differential expression of NeuN, GFAP, and CNPase in the penumbra depending on the duration of ischemia
Gene_expression (expression) of CNPase associated with ischemia
8) Confidence 0.38 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.74 Pain Relevance 0.54
In contrast, the expression level of CNPase for oligodendrocytes in the penumbra was unchanged following focal cerebral ischemia (Fig. 5A, B).


Gene_expression (expression) of CNPase in oligodendrocytes associated with brain hemorrhage and ischemia
9) Confidence 0.29 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.70 Pain Relevance 0.50
Previously, we indicated that higher number of transplanted NSPCs differentiated into oligodendrocytes expressing RIP or CNPase in the intact neonatal spinal cords [20].
Gene_expression (expressing) of CNPase in spinal cords
10) Confidence 0.29 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.17 Pain Relevance 0.11
Decreased expression of MBP and CNPase was seen in the pathologic optic nerves, along with evidence of gliosis and ongoing myelin degradation indicated by the presence of MBP fragment.
Gene_expression (expression) of CNPase in optic nerves
11) Confidence 0.28 Published 2006 Journal J Neuroophthalmol Section Body Doc Link 16845306 Disease Relevance 0.25 Pain Relevance 0
Indeed, BrdU and CNPase immunoreactive cells were detected in the ischemic boundary region and confocal images revealed co-localization BrdU in the nucleus and CNPase in the cytoplasm of the same cell (Fig. 4O-R).
Gene_expression (detected) of CNPase in nucleus
12) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.33 Pain Relevance 0.05
The pituitary displays the highest expression level of various putative paracrine/autocrine factors such as NMU and CNP, yet the function of these peptides in the pituitary remains elusive.
Gene_expression (expression) of CNP in pituitary
13) Confidence 0.23 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.13 Pain Relevance 0.12
Sections of spinal cord, dorsal root ganglia, sciatic nerve and glabrous tissue were then processed for SSeCKS and CNPase, or Pzero double immunohistochemical labeling.
Gene_expression (processed) of CNPase in sciatic nerve associated with sciatic nerve and spinal cord
14) Confidence 0.20 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.13 Pain Relevance 0.42
Sections of spinal cord, dorsal root ganglia, sciatic nerve and glabrous tissue were then processed for SSeCKS and CNPase, or Pzero double immunohistochemical labeling.
Gene_expression (processed) of CNPase in spinal cord associated with sciatic nerve and spinal cord
15) Confidence 0.07 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.13 Pain Relevance 0.42
Sections of spinal cord, dorsal root ganglia, sciatic nerve and glabrous tissue were then processed for SSeCKS and CNPase, or Pzero double immunohistochemical labeling.
Gene_expression (processed) of CNPase in dorsal root ganglia associated with sciatic nerve and spinal cord
16) Confidence 0.07 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.13 Pain Relevance 0.42
We have found that both ovCNP-39 and the endogenous C-type natriuretic peptide, CNP-22, produce oedema in the rat paw and release histamine from rat peritoneal mast cells.
Gene_expression (produce) of CNP-22 in paw associated with natriuresis and pressure and volume under development
17) Confidence 0.04 Published 1998 Journal Toxicon Section Abstract Doc Link 9663691 Disease Relevance 0.73 Pain Relevance 0.10

General Comments

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