INT76404

Context Info Confidence 0.68 First Reported 1998 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 0.87 Pain Relevance 0.68

extracellular space (Cnp) plasma membrane (Cnp) intracellular (Cnp) cytoplasm (Cnp)

Anatomy Link Frequency spinal cord 1 paw 1 corpus callosum 1 striatum 1 ventral 1 Cnp (Rattus norvegicus)

Pain Link Frequency Relevance Heat substantia gelatinosa 6 96.64 Dorsal horn 34 96.44 Pain 1 96.20 Spinal cord 46 95.68 qutenza 112 89.56 Sciatic nerve 4 80.08 dorsal root ganglion 22 70.08 unmyelinated 32 50.00 imagery 4 30.60 superficial lamina 4 28.40

Disease Link Frequency Relevance Heat Pressure And Volume Under Development 5 100.00 Natriuresis 5 99.80 Erythema 1 96.72 Pain 1 96.20 Volume Depletion And Dehydration 2 71.88 Ganglion Cysts 22 69.12 Stroke 80 50.00 Nociception 8 36.80 Middle Cerebral Artery Infarction 28 5.00 Cv Unclassified Under Development 14 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

For quantification of axons and myelinating oligodendrocytes, NF-H, CNPase, MBP, and Bielschowsky and Luxol fast blue positive areas were digitized throughout the peri-infarct corpus callosum and striatum, as well as the contralateral homologous area.

Localization (digitized) of CNPase in striatum

1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0 Pain Relevance 0

For quantification of axons and myelinating oligodendrocytes, NF-H, CNPase, MBP, and Bielschowsky and Luxol fast blue positive areas were digitized throughout the peri-infarct corpus callosum and striatum, as well as the contralateral homologous area.

Localization (digitized) of CNPase in corpus callosum

2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0 Pain Relevance 0

This was confirmed using confocal microscopy, which revealed minimal colocalization between SSeCKS and CNPase except for the occasional double-labeled puncta observed in laminae ventral to the substantia gelatinosa.

Localization (colocalization) of CNPase in ventral associated with substantia gelatinosa

3) Confidence 0.21 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.14 Pain Relevance 0.13

Evaluation of colocalization between SSeCKS and CNPase at both the fluorescence and confocal microscope level suggests myelinated axons in the dorsal horn of the spinal cord contain minimal SSeCKS-IR.

Localization (colocalization) of CNPase in spinal cord associated with dorsal horn and spinal cord

4) Confidence 0.09 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 0.46

We have found that both ovCNP-39 and the endogenous C-type natriuretic peptide, CNP-22, produce oedema in the rat paw and release histamine from rat peritoneal mast cells.

Localization (release) of CNP-22 in paw associated with natriuresis and pressure and volume under development

5) Confidence 0.02 Published 1998 Journal Toxicon Section Abstract Doc Link 9663691 Disease Relevance 0.73 Pain Relevance 0.10

General Comments

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