INT76405

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 12.77
Pain Relevance 8.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Hmox2) endoplasmic reticulum (Hmox2) plasma membrane (Hmox2)
Anatomy Link Frequency
spinal cords 2
spinal 1
Hmox2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX2 20 100.00 Very High Very High Very High
Inflammation 51 99.96 Very High Very High Very High
Spinal cord 15 99.68 Very High Very High Very High
Arthritis 23 99.60 Very High Very High Very High
endometriosis 13 99.60 Very High Very High Very High
cINOD 73 99.52 Very High Very High Very High
cOX1 6 99.32 Very High Very High Very High
Pain 21 98.10 Very High Very High Very High
IPN 2 97.24 Very High Very High Very High
Inflammatory response 3 92.16 High High
Disease Link Frequency Relevance Heat
Ulcers 4 99.98 Very High Very High Very High
INFLAMMATION 90 99.96 Very High Very High Very High
Colon Cancer 6 99.96 Very High Very High Very High
Myocardial Infarction 14 99.92 Very High Very High Very High
Disease 19 99.80 Very High Very High Very High
Arthritis 24 99.60 Very High Very High Very High
Endometriosis 9 99.60 Very High Very High Very High
Carcinoma 11 99.56 Very High Very High Very High
Brain Disease 1 99.56 Very High Very High Very High
Fracture Healing 11 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The intraspinal release of prostaglandin E2 in a model of acute arthritis is accompanied by an up-regulation of cyclo-oxygenase-2 in the spinal cord.
Positive_regulation (up-regulation) of cyclo-oxygenase-2 in spinal cord associated with cox1, spinal cord and arthritis
1) Confidence 0.43 Published 1999 Journal Neuroscience Section Title Doc Link 10465460 Disease Relevance 0.47 Pain Relevance 0.62
The maximum elevation of cyclo-oxygenase-2 protein levels (six-fold) was observed 12 h after the induction of arthritis.
Positive_regulation (elevation) of cyclo-oxygenase-2 associated with arthritis
2) Confidence 0.43 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465460 Disease Relevance 0.71 Pain Relevance 0.61
Western blot analysis revealed that cyclo-oxygenase-2 but not cyclo-oxygenase-1 protein levels were elevated in the spinal cords of animals with inflammation compared to normal animals.
Positive_regulation (elevated) of cyclo-oxygenase-2 in spinal cords associated with inflammation
3) Confidence 0.43 Published 1999 Journal Neuroscience Section Abstract Doc Link 10465460 Disease Relevance 0.71 Pain Relevance 0.57
New avenues for the prevention of colorectal cancer: targeting cyclo-oxygenase-2 activity.
Positive_regulation (targeting) of cyclo-oxygenase-2 associated with colon cancer and cox2
4) Confidence 0.39 Published 2002 Journal Best Pract Res Clin Gastroenterol Section Title Doc Link 12473300 Disease Relevance 0.72 Pain Relevance 0.13
BACKGROUND: Cyclo-oxygenase-1 (COX-1) is believed to produce prostaglandins vital to mucosal defence, whereas cyclo-oxygenase-2 (COX-2) is induced at sites of inflammation.
Positive_regulation (induced) of cyclo-oxygenase-2 associated with inflammation
5) Confidence 0.12 Published 1997 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 9663836 Disease Relevance 0.19 Pain Relevance 0.17
An observation that might favour of NSAIDs consumption as a factor promoting sensitization is that NSAIDs increase spinal expression of inducible cyclo-oxygenase-2 [29], an enzyme that contributes to sensitization in a rat model of inflammatory pain [30].
Positive_regulation (inducible) of cyclo-oxygenase-2 in spinal associated with ipn and cinod
6) Confidence 0.11 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3024248 Disease Relevance 1.09 Pain Relevance 1.80
This finding contrasts with previous claims that increased selectivity for cyclo-oxygenase-2 inhibitors is associated with increased cardiovascular risk.36 Several mechanisms have been postulated, but the hypothesis of an imbalance between prostacyclin and thromboxane A2 leading to an increased risk for thombotic events gained most prominence.37 However, the lack of a clear association between specificity of cyclo-oxygenase-2 inhibitors and cardiovascular risk implies that other mechanisms need to be considered.
Positive_regulation (increased) of cyclo-oxygenase-2
7) Confidence 0.09 Published 2011 Journal BMJ : British Medical Journal Section Body Doc Link PMC3019238 Disease Relevance 0.06 Pain Relevance 0.10
Synergy between cyclo-oxygenase-2 induction and arachidonic acid supply in vivo: consequences for nonsteroidal antiinflammatory drug efficacy.
Positive_regulation (induction) of cyclo-oxygenase-2 associated with inflammation and cox2
8) Confidence 0.06 Published 1999 Journal FASEB J. Section Title Doc Link 9973312 Disease Relevance 0.31 Pain Relevance 0.41
Cyclo-oxygenase 2 (COX-2) is induced at inflammation sites and produces proinflammatory prostaglandins.
Positive_regulation (induced) of Cyclo-oxygenase 2 associated with inflammation
9) Confidence 0.06 Published 2002 Journal J. Bone Miner. Res. Section Abstract Doc Link 12054171 Disease Relevance 0.84 Pain Relevance 0.34
Inhibition of Helicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils.
Positive_regulation (induced) of cyclo-oxygenase-2 associated with ulcers, cinod and cox1
10) Confidence 0.05 Published 2002 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 11929405 Disease Relevance 0.10 Pain Relevance 0.25
Thus, during exercise, nabumetone may decrease the excretion of 6-oxo-PGF(1alpha) by inhibition of cyclo-oxygenase-1 or by inhibition of specific exercise-induced activation of cyclo-oxygenase-2, or both.
Positive_regulation (activation) of cyclo-oxygenase-2
11) Confidence 0.04 Published 1999 Journal Clin. Sci. Section Abstract Doc Link 10491346 Disease Relevance 0.07 Pain Relevance 0.11
CONCLUSIONS: Our results suggest that cyclo-oxygenase-2 protein induced by H. pylori infection may be involved in the defence of the gastric mucosa against damage caused by non-steroidal anti-inflammatory drugs.
Positive_regulation (induced) of cyclo-oxygenase-2
12) Confidence 0.03 Published 2002 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 11929405 Disease Relevance 0 Pain Relevance 0
BACKGROUND: The potential for cyclo-oxygenase 2 (COX2)-selective inhibitors to increase the risk for myocardial infarction is controversial.
Positive_regulation (increase) of cyclo-oxygenase 2 associated with cox2 and myocardial infarction
13) Confidence 0.02 Published 2004 Journal Lancet Section Abstract Doc Link 15325832 Disease Relevance 0.27 Pain Relevance 0.26
Cyclo-oxygenase 2 enzyme is constitutively expressed in neurons and is up-regulated in degenerative brain regions in AD.
Positive_regulation (up-regulated) of Cyclo-oxygenase 2 enzyme associated with disease
14) Confidence 0.01 Published 2000 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 10696521 Disease Relevance 2.68 Pain Relevance 0.80
Recently, a new class of inhibitors of the inducible enzyme cyclo-oxygenase-2 have become available.
Positive_regulation (inducible) of cyclo-oxygenase-2
15) Confidence 0.01 Published 2001 Journal Dig Liver Dis Section Abstract Doc Link 11827363 Disease Relevance 0.80 Pain Relevance 0.70
Regular administration of non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the incidence of colorectal cancer by targeting cyclo-oxygenase-2 (Cox-2), a key enzyme in arachidonic acid metabolism.
Positive_regulation (targeting) of cyclo-oxygenase-2 associated with inflammation, colon cancer and cinod
16) Confidence 0.01 Published 1999 Journal J. Pathol. Section Abstract Doc Link 10398082 Disease Relevance 0.87 Pain Relevance 0.20
BACKGROUND: Selective cyclo-oxygenase-2 (COX-2) inhibitors were recently introduced for the treatment of arthritis because of their lower rates of gastrointestinal adverse events compared with traditional non-steroidal anti-inflammatory drugs (NSAIDs).
Positive_regulation (introduced) of cyclo-oxygenase-2 associated with inflammation, cinod and arthritis
17) Confidence 0.01 Published 2003 Journal Curr Med Res Opin Section Abstract Doc Link 14606981 Disease Relevance 0.34 Pain Relevance 0.28
Additionally, estrogen itself stimulates cyclo-oxygenase-2 and therefore increases the formation of prostaglandin E (2) in endometriosis.
Positive_regulation (stimulates) of cyclo-oxygenase-2 associated with endometriosis
18) Confidence 0.00 Published 2004 Journal Semin. Reprod. Med. Section Abstract Doc Link 15083380 Disease Relevance 0.70 Pain Relevance 0.47
PGE(2) production in endometriosis is up-regulated by increased levels of the enzyme cyclo-oxygenase-2 (COX-2) in this tissue.
Positive_regulation (increased) of cyclo-oxygenase-2 associated with endometriosis
19) Confidence 0.00 Published 2006 Journal Hum. Reprod. Update Section Abstract Doc Link 16123052 Disease Relevance 1.00 Pain Relevance 0.42
A new generation of non-steroidal anti-inflammatory drugs has been described that selectively targets the inducible isoform of cyclo-oxygenase, cyclo-oxygenase 2 (COX-2).
Positive_regulation (targets) of cyclo-oxygenase 2 associated with inflammation and cinod
20) Confidence 0.00 Published 2000 Journal Lancet Section Abstract Doc Link 10696997 Disease Relevance 0.62 Pain Relevance 0.36

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