INT76406

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 140
Total Number 144
Disease Relevance 85.86
Pain Relevance 17.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1)
cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)
Anatomy Link Frequency
liver 6
blood 5
epithelium 5
glial cells 4
ventricles 3
Hmox1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 1053 100.00 Very High Very High Very High
Calcitonin gene-related peptide 40 100.00 Very High Very High Very High
cytokine 405 99.88 Very High Very High Very High
Rostral ventrolateral medulla 19 99.84 Very High Very High Very High
qutenza 26 99.76 Very High Very High Very High
Spinal cord 5 99.68 Very High Very High Very High
ischemia 230 99.48 Very High Very High Very High
Paracetamol 83 98.52 Very High Very High Very High
fibrosis 597 98.00 Very High Very High Very High
Inflammatory mediators 47 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1243 100.00 Very High Very High Very High
Stress 779 100.00 Very High Very High Very High
Fibrosis 727 100.00 Very High Very High Very High
Diabetes Mellitus 1423 99.84 Very High Very High Very High
Multiple Sclerosis 6 99.68 Very High Very High Very High
Injury 400 99.64 Very High Very High Very High
Adult Respiratory Distress Syndrome 125 99.60 Very High Very High Very High
Hyperoxia 50 99.50 Very High Very High Very High
Cv Unclassified Under Development 216 99.48 Very High Very High Very High
Ureteral Obstruction 585 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inducible expression of HO-1 is considered a protective cellular mechanism against reactive oxygen intermediates.
Gene_expression (expression) of HO-1
1) Confidence 0.78 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024540 Disease Relevance 0.48 Pain Relevance 0.18
Here we report expression of HO-1 in rat experimental autoimmune encephalomyelitis (EAE) and neuritis (EAN).
Gene_expression (expression) of HO-1 associated with multiple sclerosis and neuritis
2) Confidence 0.78 Published 2000 Journal J. Neuroimmunol. Section Abstract Doc Link 11024540 Disease Relevance 0.72 Pain Relevance 0.24
For demonstrating the protective role of HO-1, its enzymatic activity was competitively inhibited by administration of zinc protoporphyrin IX (ZnPPIX), and HO-1 synthesis was blocked with HO-1 siRNA.
Gene_expression (synthesis) of HO-1
3) Confidence 0.77 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 0.77 Pain Relevance 0.34
Expression and protective role of heme oxygenase-1 in delayed myocardial preconditioning.
Gene_expression (Expression) of heme oxygenase-1
4) Confidence 0.77 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 17404038 Disease Relevance 0.62 Pain Relevance 0.31
In the study the authors aimed to demonstrate the expression and protective effect of heme oxygenase-1 (HO-1) in the delayed preconditioning (PC) on cultured myocardiac cells.
Gene_expression (expression) of heme oxygenase-1
5) Confidence 0.77 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 0.29 Pain Relevance 0.20
HO-1 immunostaining showed an appreciable HO-1 expression in PC groups, which was abolished with HO-1 siRNA administration, but not in ZnPPIX group.
Gene_expression (expression) of HO-1
6) Confidence 0.77 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 0.75 Pain Relevance 0.34
HO-1 expression in all of the groups was demonstrated with immunostaining.
Gene_expression (expression) of HO-1
7) Confidence 0.77 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 0.80 Pain Relevance 0.37
In the study the authors aimed to demonstrate the expression and protective effect of heme oxygenase-1 (HO-1) in the delayed preconditioning (PC) on cultured myocardiac cells.
Gene_expression (expression) of HO-1
8) Confidence 0.77 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 0.29 Pain Relevance 0.20
The results therefore suggest that HO-1 expression increases in both ischemic and pharmacological PC, and HO-1 has cellular protective effect against cell death and apoptosis in ischemia-reperfusion-induced oxidative injury.
Gene_expression (expression) of HO-1 associated with ischemia, injury, apoptosis and death
9) Confidence 0.77 Published 2007 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17404038 Disease Relevance 1.07 Pain Relevance 0.33
Hyperthermic preconditioning induces strong and long lasting HO-1/HSP32, HSP72, and HSP90 expression in rat kidneys.
Gene_expression (expression) of HSP32
10) Confidence 0.77 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 0.60 Pain Relevance 0.03
HO-1/HSP32 and HSP72 were found to be expressed constitutively.
Gene_expression (expressed) of HSP32
11) Confidence 0.77 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 1.10 Pain Relevance 0.21
HO-1/HSP32 and HSP72 were found to be expressed constitutively.
Gene_expression (expressed) of HO-1
12) Confidence 0.77 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 1.10 Pain Relevance 0.21
Hyperthermic preconditioning induces strong and long lasting HO-1/HSP32, HSP72, and HSP90 expression in rat kidneys.
Gene_expression (expression) of HO-1
13) Confidence 0.77 Published 2001 Journal Transpl. Int. Section Abstract Doc Link 11793032 Disease Relevance 0.60 Pain Relevance 0.03
For example, smoking has been proved to increase the expression of HO-1 in airway tissues.29
Gene_expression (expression) of HO associated with nicotine addiction
14) Confidence 0.75 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 1.25 Pain Relevance 0
Our findings are approximately consistent with previous studies in that up-regulation of HO-1 mRNA expression has been revealed under oxidative stress situation.
Gene_expression (expression) of HO-1 mRNA associated with stress
15) Confidence 0.75 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.15 Pain Relevance 0
The main reason for this result is that despite of HO-1, HO-2 is not an inducible isoform and constitutively expressed for the most part of the body.11,16,17
Gene_expression (expressed) of HO in body
16) Confidence 0.75 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.09 Pain Relevance 0
While unexposed SM samples expressed same levels of HOs, expression level of HO-1 was upregulated about 3.58 ± 1.93 folds in SM exposed patients in comparison with unexposed ones, we could not find any difference in expression of HO-2 n two groups.
Gene_expression (expression) of HO
17) Confidence 0.75 Published 2010 Journal Gene Regul Syst Bio Section Abstract Doc Link PMC2956478 Disease Relevance 0.36 Pain Relevance 0
The main reason for this result is that despite of HO-1, HO-2 is not an inducible isoform and constitutively expressed for the most part of the body.11,16,17
Gene_expression (expressed) of HO in body
18) Confidence 0.75 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.09 Pain Relevance 0
To summarize, this study demonstrated in spite of the fact that expression of HO-1 at mRNA levels in SM injured veterans significantly increased compared to the control group, no notable presence of HO-1 proteins were reported in the airway wall of the patients.
Gene_expression (expression) of HO
19) Confidence 0.75 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.05 Pain Relevance 0
Interestingly, the expression of HO-1 is amplified in alveolar macrophages of lung transplant recipients suffered from BO and acute cellular rejection (ACR) and is in accordance with the capacity for rejection in a rat lung transplant model of ACR.
Gene_expression (expression) of HO in lung associated with bronchiolitis obliterans
20) Confidence 0.75 Published 2010 Journal Gene Regul Syst Bio Section Body Doc Link PMC2956478 Disease Relevance 0.98 Pain Relevance 0.04

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