INT76415

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Context Info
Confidence 0.18
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.56
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
T-cell 3
plasma 2
Il5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 21 100.00 Very High Very High Very High
Migraine 9 98.16 Very High Very High Very High
Sumatriptan 1 78.56 Quite High
antagonist 3 66.64 Quite High
Inflammation 19 60.24 Quite High
Pain 18 50.00 Quite Low
cINOD 4 50.00 Quite Low
Lasting pain 2 50.00 Quite Low
diclofenac 20 21.00 Low Low
Analgesic 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 15 99.00 Very High Very High Very High
Headache 7 98.16 Very High Very High Very High
Migraine Without Aura 3 96.84 Very High Very High Very High
Nasal Polyps 53 96.72 Very High Very High Very High
Polyps 15 95.48 Very High Very High Very High
Asthma 8 95.32 Very High Very High Very High
Pain 14 88.40 High High
Rhinitis 4 79.92 Quite High
Disease 167 79.20 Quite High
Aspergillus Infection 1 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of the IL-5 receptor has also been investigated with down regulation being found to occur in NP, especially in association with asthma (Gaevert et al 2003).
Regulation (regulation) of IL-5 associated with asthma and nasal polyps
1) Confidence 0.18 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504067 Disease Relevance 1.41 Pain Relevance 0
Plasma levels of interleukin (IL)-4, IL-5, IL-10, and interferon-gamma were measured by enzyme-linked immunosorbent assay techniques.
Regulation (measured) of IL-5 in Plasma
2) Confidence 0.04 Published 2001 Journal Headache Section Abstract Doc Link 11576199 Disease Relevance 0.27 Pain Relevance 0.40
A second group of AID, which included VD(3), HC and DMF, suppressed mainly type-1 T cell responses, as revealed by strong interference with IFN-gamma production and CXCR3 expression, and limited effects on either or both IL-5 and CCR4 expression.
Regulation (effects) of IL-5 in T cell
3) Confidence 0.02 Published 2004 Journal Clin. Exp. Allergy Section Body Doc Link 15663561 Disease Relevance 0 Pain Relevance 0
To this end, plasma levels of IFN-gamma, IL-4, IL-5, and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA) techniques.
Regulation (measured) of IL-5 in plasma
4) Confidence 0.01 Published 1998 Journal Headache Section Abstract Doc Link 9664752 Disease Relevance 0.34 Pain Relevance 0.52
The concentrations of TNF-alpha, GM-CSF, interleukin (IL)-1beta, IL-6, IL-8, interferon (IFN)-gamma, IL-2, IL-4, IL-5, IL-10 and nitrate/nitrite were determined.
Regulation (concentrations) of IL-5
5) Confidence 0.01 Published 2007 Journal Inflamm. Res. Section Body Doc Link 17334668 Disease Relevance 0.17 Pain Relevance 0
Imiqui-mod has indirect effects on T-cells and T-cell cytokines (eg, IL-2, IL-4, IL-5) by the induction of IFN-?
Regulation (effects) of IL-5 in T-cell associated with cytokine
6) Confidence 0.00 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621408 Disease Relevance 0.68 Pain Relevance 0.24
Imiqui-mod has indirect effects on T-cells and T-cell cytokines (eg, IL-2, IL-4, IL-5) by the induction of IFN-?
Regulation (effects) of IL-5 in T-cells associated with cytokine
7) Confidence 0.00 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621408 Disease Relevance 0.68 Pain Relevance 0.24

General Comments

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