INT76416

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Context Info
Confidence 0.08
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.16
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
plasma 4
mast cells 4
PBMC 2
Il5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Migraine 10 99.96 Very High Very High Very High
cytokine 27 99.70 Very High Very High Very High
Sumatriptan 1 98.82 Very High Very High Very High
Inflammatory response 1 98.08 Very High Very High Very High
fibrosis 2 89.32 High High
aspirin 76 86.88 High High
cINOD 14 76.48 Quite High
alcohol 1 61.68 Quite High
Inflammation 13 50.00 Quite Low
Angina 5 48.48 Quite Low
Disease Link Frequency Relevance Heat
Hypersensitivity 14 99.96 Very High Very High Very High
Headache 7 99.96 Very High Very High Very High
Rhinitis 12 99.76 Very High Very High Very High
Migraine Without Aura 3 98.52 Very High Very High Very High
Systemic Inflammatory Response Syndrome 5 98.44 Very High Very High Very High
Asthma 139 94.20 High High
Lung Cancer 1 93.36 High High
Lymphatic System Cancer 1 92.44 High High
Increased Venous Pressure Under Development 3 89.80 High High
Endomyocardial Fibrosis 1 89.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, Df stimulation increased IL-5 production only.
Positive_regulation (increased) of Gene_expression (production) of IL-5
1) Confidence 0.08 Published 1999 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 10619341 Disease Relevance 0.06 Pain Relevance 0
RESULTS: Stimulation with ConA increased the production of IL-5 and IFN-gamma.
Positive_regulation (increased) of Gene_expression (production) of IL-5
2) Confidence 0.08 Published 1999 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 10619341 Disease Relevance 0.07 Pain Relevance 0
After treatment with sumatriptan, 10 patients showed a subsequent decrease in IL-10 and an increase in both IL-4 and IL-5 plasma levels.
Positive_regulation (increase) of Gene_expression (levels) of IL-5 in plasma associated with sumatriptan
3) Confidence 0.08 Published 2001 Journal Headache Section Abstract Doc Link 11576199 Disease Relevance 0.24 Pain Relevance 0.50
Dermatophagoides farinae-induced overproduction of IL-5 was inhibited by SCG and Dex.
Positive_regulation (overproduction) of Gene_expression (overproduction) of IL-5
4) Confidence 0.06 Published 1999 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 10619341 Disease Relevance 0.06 Pain Relevance 0
Dermatophagoides farinae-induced overproduction of IL-5 was inhibited by SCG and Dex.
Positive_regulation (farinae-induced) of Gene_expression (overproduction) of IL-5
5) Confidence 0.06 Published 1999 Journal Ann. Allergy Asthma Immunol. Section Body Doc Link 10619341 Disease Relevance 0.06 Pain Relevance 0
Cytokines and migraine: increase of IL-5 and IL-4 plasma levels.
Positive_regulation (increase) of Gene_expression (levels) of IL-5 in plasma associated with migraine and cytokine
6) Confidence 0.06 Published 1998 Journal Headache Section Title Doc Link 9664752 Disease Relevance 0.37 Pain Relevance 0.62
Pathogenesis includes both immediate (immunoglobulin E degranulation of mast cells and basophiles) and delayed hypersensitivity reactions (activation of TH and IL-5 production).
Positive_regulation (activation) of Gene_expression (production) of IL-5 in mast cells associated with hypersensitivity
7) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2830978 Disease Relevance 2.13 Pain Relevance 0.04
Ex vivo production of interleukin-2 (IL-2), IL-4, IL-5, and IL-10 by peripheral blood mononuclear cells (PBMC) was studied in 13 septic patients with infectious systemic inflammatory response syndrome (SIRS) and 13 patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) (noninfectious SIRS).
Positive_regulation (studied) of Gene_expression (production) of IL-5 in PBMC associated with inflammatory response and systemic inflammatory response syndrome
8) Confidence 0.03 Published 2000 Journal Shock Section Abstract Doc Link 10718372 Disease Relevance 0.35 Pain Relevance 0.13
The cytokine profile of the mast cell was investigated in another study and reported an increase in bronchial submucosal mast cells expressing interleukin-5 and granulocyte-macrophage colony-stimulating factor[44].
Positive_regulation (increase) of Gene_expression (expressing) of interleukin-5 in mast cells associated with cytokine
9) Confidence 0.01 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.81 Pain Relevance 0.36

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