INT76417

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Context Info
Confidence 0.09
First Reported 1998
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.34
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
immune cells 2
beta cell 2
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 10 100.00 Very High Very High Very High
opioid receptor 4 98.74 Very High Very High Very High
Migraine 5 98.64 Very High Very High Very High
cytokine 5 90.08 High High
mu opioid receptor 1 83.44 Quite High
Opioid 1 61.24 Quite High
Disease Link Frequency Relevance Heat
Migraine Without Aura 2 98.64 Very High Very High Very High
Headache 3 87.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low
Viral Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine administration was also found to inhibit IL-4 induced up-regulation of MHC II RT1.B beta cell surface expression on B lymphocytes.
Positive_regulation (induced) of Positive_regulation (up-regulation) of IL-4 in beta cell associated with morphine
1) Confidence 0.09 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 14742686 Disease Relevance 0 Pain Relevance 0.65
Of interest, we observed a strong increase of IL-5 levels in 84.3% as well as increased IL-4 levels in 37.5% of patients with migraine without aura.
Positive_regulation (increase) of Positive_regulation (increase) of IL-4 associated with migraine
2) Confidence 0.06 Published 1998 Journal Headache Section Abstract Doc Link 9664752 Disease Relevance 0.34 Pain Relevance 0.55
Nevertheless, mu-opioid receptor mRNA in immune cells is processed to functional receptors, as demonstrated by morphine-mediated phosphorylation of mitogen activated protein kinase, morphine-mediated up-regulation of IL-4 mRNA and coupling to adenylyl cyclase in Jurkat cells.
Positive_regulation (demonstrated) of Positive_regulation (up-regulation) of IL-4 in immune cells associated with opioid receptor and morphine
3) Confidence 0.02 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17561272 Disease Relevance 0 Pain Relevance 0.50

General Comments

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